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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Framing effects within the ethical decision making process of consumers显示文摘 | Bateman C R Fraedrich J P Iyer R | 2002 | Journal of Business Ethics2002，36，12： | 1 |
| 4 | Mucosal expression of cyclooxygenase isoforms 1 and 2 is increased with worsening damage to the gastric mucosa显示文摘 | A C Bateman R L Mehta | 2005 | Histopathology2005，46，3： | 1 |
| 5 | Variation of major chemical consituents across the central Sierra Nevada Batholith显示文摘 | Bateman P C Dodge C W | 1970 | Bulletin of geological society of America1970，81，： | 1 |
| 6 | The Pfam protein families database 显示文摘 | Punta M Coggill P C Eberhardt R Y Mistry J Tate J Boursnell C Pang N Forslund K Ceric G Clements J Hcger A Holm L Sonnhammer E L Eddy S R Bateman A Finn R D | 2012 | Nucleic Acids Research2012，40，： | 1 |
| 7 | A new locus for autosomal dominant cata- ract on chromosome 12q13 显示文摘 | Bateman JB Johannes M Flodman P Geyer DD Clancy KP Heinzmann C eta/ | 2000 | Invest Ophthalmol Vis Sci2000，41，9： | 1 |
| 8 | Development of strategies for the incorporation of microbial pesticides into the integrated management of locusts and grasshoppers显示文摘 | Lomer C J Bateman R P de Groote H | 1999 | Journal of Agricultural and Forest Entomology1999，1，： | 1 |
| 9 | Some observation on the dose transfer of mycoinsecticide sprays to desert locusts 显示文摘 | Bateman R P Douro-kpindou O P Kooyman C | 1998 | Crop Protection1998，17，： | 1 |
| 10 | On the calculation of the water particle kinematics arising in a directionally spread wavefield显示文摘 | Bateman W J D Swan C Taylor P H | 2003 | Journal of Computational Physics2003，186，： | 1 |
| 11 | Framing Effects Within The Ethical Decision Making P Rocess of Consumers 显示文摘 | Bateman C R Fraedrich J P Iyer R | 2002 | Jour- nal of Business Ethics2002，36，12： | 1 |
| 12 | To disclose or not: Pub- licness in social networking sites 显示文摘 | Bateman P J Pike J C Butler B S | 2011 | Information Technolo- gy & People2011，24，1： | 1 |
| 13 | On the efficient numerical simulation of directionally spread surface water waves显示文摘 | Bateman W J D Swan C Taylor P H | 2001 | Journal of Computational Physics2001，174，： | 1 |
| 14 | Mechanism for the role of magnesia in the sintering of alumina containing small amounts of a liquid phase 显示文摘 | BATEMAN C A BENNISON S J HA1MER M P | 1989 | J Am Ceram Soc1989，72，7： | 1 |
| 15 | Development of strategies for the incorporation of biological pesticides into the integrated management of locusts and grasshoppers显示文摘 | Lomer C J Bateman R P Dent D | 1999 | Agri Forest Entomol1999，1，： | 1 |
| 16 | Variation of major chemical consituents across the central Sierra Nevada Batholith 显示文摘 | Bateman P C Dodge C W | 1970 | Bulletin ofgeological society of America1970，81，： | 1 |
| 17 | Some observation on the dose transfer of mycoinsecticide sprays to desert locusts显示文摘 | Bateman R P Douro-kpindou O P Kooyman C | 1998 | Crop Protection1998，17，： | 1 |
| 18 | Annu Rev Entomol显示文摘 | Lomer C J Bateman R P Johnson D L | 2001 | 46: 667-7022001，46，： | 1 |
| 19 | Biological control of locusts and Grasshoppers 显示文摘 | LOMER C J BATEMAN R P LANGEWALD J | 2001 | Ann Rev Entomol2001，46，： | 1 |
| 20 | Some observation on the dose transfer of mycoinsecticide sprays to desert locusts 显示文摘 | Douro-kipindou O P Kooyman C | 1998 | Crop Protection1998，，17： | 1 |
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