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| 1 | Diffusion-weighted imaging of pancreatic cancer显示文摘Magnetic resonance imaging(MRI) is a reliable and accurate imaging method for the evaluation of patients with pancreatic ductal adenocarcinoma(PDAC). Diffusion-weighted imaging(DWI) is a relatively recent technological improvement that expanded MRI capabilities, having brought functional aspects into conventional morphologic MRI evaluation. DWI can depict the random diffusion of water molecules within tissues(the so-called Brownian motions). Modifications of water diffusion induced by different factors acting on the extracellular and intracellular spaces, as increased cell density, edema, fibrosis, or altered functionality of cell membranes, can be detected using this MR sequence. The intravoxel incoherent motion(IVIM) model is an advanced DWI technique that consent a separate quantitative evaluation of all the microscopic random motions that contribute to DWI, which are essentially represented by molecular diffusion and blood microcirculation(perfusion). Technological improvements have made possible the routine use of DWI during abdominal MRI study. Several authors have reported that the addition of DWI sequence can be of value for the evaluation of patients with PDAC, especially improving the staging; nevertheless, it is still unclear whether and how DWI could be helpful for identification, characterization, prognostic stratification and follow-up during treatment. The aim of this paper is to review up-to-date literature data regarding the applications of DWI and IVIM to PDACs. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Flavia Dal Corso Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Radiology2015，7，10： | 14 |
| 2 | Prognostication and response assessment in liver and pancreatic tumors:The new imaging显示文摘Diffusion-weighted imaging(DWI), dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) and perfusion computed tomography(CT) are technical improvements of morphologic imaging that can evaluate functional properties of hepato-bilio-pancreatic tumors during conventional MRI or CT examinations.Nevertheless, the term 'functional imaging' is commonly used to describe molecular imaging techniques, as positron emission tomography(PET)CT/MRI, which still represent the most widely used methods for the evaluation of functional properties of solid neoplasms; unlike PET or single photon emission computed tomography, functional imaging techniques applied to conventional MRI/CT examinations do not require the administration of radiolabeled drugs or specific equipments. Moreover, DWI and DCE-MRI can be performed during the same session, thus providing a comprehensive 'one-step' morphological and functional evaluation of hepato-bilio-pancreatic tumors. Literature data reveal that functional imaging techniques could be proposed for the evaluation of these tumors before treatment, given that they may improve staging and predict prognosis or clinical outcome. Microscopic changes within neoplastic tissues induced by treatments can be detected and quantified with functional imaging,therefore these techniques could be used also for posttreatment assessment, even at an early stage. The aim of this editorial is to describe possible applications of new functional imaging techniques apart frommolecular imaging to hepatic and pancreatic tumors through a review of up-to-date literature data, with a particular emphasis on pathological correlations,prognostic stratification and post-treatment monitoring. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Gino Puntel Silvia Ortolani Sara Cingarlini Andrea Ruzzenente Alfredo Guglielmi Giampaolo Tortora Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Gastroenterology2015，21，22： | 10 |
| 3 | Percutaneous ablation of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma is a highly aggressive tumor with an overall 5-year survival rate of less than 5%. Prognosis and treatment depend on whether the tumor is resectable or not, which mostly depends on how quickly the diagnosis is made. Chemotherapy and radiotherapy can be both used in cases of nonresectable pancreatic cancer. In cases of pancreatic neoplasm that is locally advanced, non-resectable, but non-metastatic, it is possible to apply percutaneous treatments that are able to induce tumor cytoreduction. The aim of this article will be to describe the multiple currently available treatment techniques(radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation), their results, and their possible complications, with the aid of a literature review. | Mirko D'Onofrio Valentina Ciaravino Riccardo De Robertis Emilio Barbi Roberto Salvia Roberto Girelli Salvatore Paiella Camilla Gasparini Nicolò Cardobi Claudio Bassi | 2016 | World Journal of Gastroenterology2016，22，44： | 7 |
| 4 | Radiofrequency ablation of locally advanced pancreatic adenocarcinoma:An overview显示文摘Radiofrequency ablation(RFA)of pancreatic neoplasms is restricted to locally advanced,non-resectable but nonmetastatic tumors.RFA of pancreatic tumors is nowadays an ultrasound-guided procedure performed during laparotomy in open surgery.Intraoperative ultrasound covers the mandatory role of staging,evaluation of feasibility,guidance and monitoring of the procedure.Different types of needle can be used.The first aim in the evaluation of RFA as a treatment for locally advanced pancreatic ductal adenocarcinoma,in order of evaluation but not of importance,is to determine the feasibility of the procedure.The second aim is to establish the effect of RFA on tumoral mass in terms of necrosis andcytoreduction.The most important aim,third in order of evaluation,is the potential improvement of quality of life and survival rate.Nowadays,only a few studies assess the feasibility of the procedure.The present paper is an overview of RFA for pancreatic adenocarcinoma. | Mirko D’Onofrio Emilio Barbi Roberto Girelli Enrico Martone Anna Gallotti Roberto Salvia Paolo Tinazzi Martini Claudio Bassi Paolo Pederzoli Roberto Pozzi Mucelli | 2010 | World Journal of Gastroenterology2010，16，28： | 6 |
| 5 | Pioneering drugs for overactive bladder and detrusor overactivity: Ongoing research and future directions显示文摘The ongoing research on pioneering drug candidates for the overactive bladder(OAB) aimed to overcome the limitations of currently licensed pharmacotherapies, such as antimuscarinics, β3-adrenergic agents, and botulinum neurotoxin, has been reviewed performing a systematic literature review and web search. The review covers the exploratory agents alternative to available medications for OAB and that may ultimately prove to be therapeutically useful in the future management of OAB patients based on preclinical and early clinical data. It emerges that many alternative pharmacological strategies have been discovered or are under investigation in disease-oriented studies. Several potential therapeutics are known for years but still find obstacles to pass the clinical stages of development, while other completely novel compounds, targeting new pharmacological targets, have been recently discovered and show potential to translate into clinical therapeutic agents for idiopathic and neurogenic OAB syndrome. The global scenario of investigational drugs for OAB gives promise for the development of innovative therapeutics that may ultimately prove effective as first, combined or second-line treatments within a realistic timescale of ten years. | Emilio Sacco Salvatore Recupero Riccardo Bientinesi Giuseppe Palermo Daniele D'Agostino Diego Currò Pierfrancesco Bassi | 2015 | World Journal of Obstetrics and Gynecology2015，4，2： | 3 |
| 6 | HP-NAP inhibits the growth of bladder cancer in mice by activating a cytotoxic Th1 response显示文摘 | Gaia Codolo Matteo Fassan Fabio Munari Andrea Volpe Piefrancesco Bassi Massimo Rugge Francesco Pagano Mario Milco D’Elios Marina Bernard | 2012 | Cancer Immunology Immunotherapy2012，，1： | 2 |
| 7 | Comparison of marginal fit of 3 different metal-ceramic systems: an in vitro study显示文摘 | Petteno D Schierano G Bassi F | 2000 | Int-J-Prosthodont2000，13，： | 1 |
| 8 | T1 is an integral component of an antibody panel to distinguish pancreatieobiliary and some ovari-an epithelial neoplasms显示文摘 | W Goldstein NS Bassi D Uzieblo A | 2001 | Am J Clin Pathol2001，116，2： | 1 |
| 9 | Impact of aerobic exercise training on Heart Rate Variability and functional capacity in obese women after gastric bypass sur- gery显示文摘 | CASTELLO V BASSI D AUDREY BORGHI-SILVA | 2011 | Obes Surg2011，21，： | 1 |
| 10 | Asymptotically stable visual servoing of manipulators via neural networks显示文摘 | Kelly R Favela J Bassi D | 2000 | Journal of Robotic Systems2000，17，12： | 1 |
| 11 | Probabilistic diffusion tractography of the optic radiations and visual function in preterm infants at term equivalent age显示文摘 | Ricci D Volzone A | 2008 | Brain2008，131，： | 1 |
| 12 | Diagnosis, objective assessment of severity,and management of acute pancreatitis显示文摘 | Dervenis C Johnson C D Bassi C | 1999 | Int J Pancreatol1999，25，： | 1 |
| 13 | Efficiency of the DNA repair and polymorphisms of the XRCC!, XRCC3 and XRCC4 DNA repair genes in systemic lupus erythematosus 显示文摘 | Bassi CL Xavier D J Palomino GM | 2008 | Lupus2008，17，11： | 1 |
| 14 | Anti-epidermal growth factor receptor monoclonal antibody cetuximab inhibits EGFR/HER-2 heterodimerization and activation显示文摘 | Patel D Bassi R Hooper A | 2009 | Int J Oncol2009，34，1： | 1 |
| 15 | Simultaneous determination of soluble sugars and organic acids as their trimethylsilyl derivatives in apricot fruits by gas-liquid chromatography显示文摘 | Bartolozzi F Bertazza G Bassi D Cristoferi G | 1997 | J Chromatography A1997，758，： | 1 |
| 16 | WTI is an integral component of an antibody panel to distinguish pancreaticobiliary and some ovarian epithelial neoplasms 显示文摘 | Goldstein NS Bassi D Uzieblo A | 2001 | Am J Clin Pathol2001，116，2： | 1 |
| 17 | Development ofprotocols for in vitro rooting of advanced selections of Pyrus communls rootstocks显示文摘 | Previati A Da Re F Bassi D | 2002 | Aeta Hortie2002，596，： | 1 |
| 18 | Chlorophyll-protein complexes of baley photosysteu I 显示文摘 | Bassi R Simpson D | 1987 | Eur J Biochem1987，163，2： | 1 |
| 19 | Tolerance of apricot to winter temperature fluctuation and spring frost in Northern Italy显示文摘 | BASSI D ANDALO G BARTOLOZZI F | 1995 | Acta Horticulturae1995，384，： | 1 |
| 20 | Microwave Thermal Ablation for Hepatocarcinoma: Six Liver Transplantation Cases显示文摘 | G. Zanus R. Boetto E. Gringeri A. Vitale F. D’Amico A. Carraro D. Bassi P. Bonsignore G. Noaro C. Mescoli M. Rugge P. Angeli M. Senzolo P. Burra P. Feltracco U. Cillo | 2011 | Transplantation Proceedings2011，，4： | 1 |
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