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| 1 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 2 | Semaphorin 4D provides a link between axon guidance processes and tumorinduced angiogenesis显示文摘 | Basile J R Castilho R M Williams V P | 2006 | Proc Natl Acad Sci USA2006，103，24： | 1 |
| 3 | Antimi- crobial and antioxidant activities of Feijoa sellowiana fruit显示文摘 | VUOTYO M L BASILE A MOSCATIELLO V DE SOLE P CASTALDO-COBIANCHI R LAGHIA E IELPO M T L | 2000 | Antimi- crobial Agents2000，13，： | 1 |
| 4 | Distribution and functional characterization of pituitary adenylate cyclaseactivating polypeptide receptors in the brain of non-human primates显示文摘 | Jolivel V Basille M Aubert N | 2009 | Neuroscience2009，160，2： | 1 |
| 5 | Semaphorin 4D provides a link between axon guidance processes and tumor- induced angiogenesis显示文摘 | Basile J R Castilho R M Williams V P | 2006 | Proc Natl Acad Sci U S A2006，103，24： | 1 |
| 6 | Immunopharmacological properties of flavonoids显示文摘 | M.T.L Ielpo A Basile R Miranda V Moscatiello C Nappo S Sorbo E Laghi M.M Ricciardi L Ricciardi M.L Vuotto | 2000 | Fitoterapia2000，，： | 1 |
| 7 | Curcumin derivatives: molecular basis of their anti-cancer activity 显示文摘 | Basile V Ferrari E Lazzari S | 2009 | Biochem Pharmacol2009，78，13： | 1 |
| 8 | Association of the Msc I polymorphisn of dopamine D3 receptor gene with tardive dyskinesia in xchizophrenia 显示文摘 | Basile V Masellis M Badri F | 1999 | Neuropsychopharmacology1999，21，1： | 1 |
| 9 | Serotonin sub-type 2 receptor genes and clinical response to clozapine in schizo-phrenia patients显示文摘 | MASELLIS M BASILE V MELTZER HY | 1998 | Neuropsychopharmacology1998，19，2： | 1 |
| 10 | Antimicrobial and antioxi- dant activities of coumarins from the roots of Ferulago campestris (Apiaceae) 显示文摘 | Basile A Sorbo S Spadaro V | 2009 | Molecules2009，14，： | 1 |
| 11 | Renal abnoalites in In mayer rokitanski kuster hauser sydrome 显示文摘 | Basile C De-Mechele V | 2001 | J Nephrol2001，14，： | 1 |
| 12 | New drugs in cancer therapy,national tumor institute,naples,17-18 June 2004显示文摘 | Caponigro F Basile M de Rosa V etal | 2005 | Anticancer Drugs2005，16，2： | 1 |
| 13 | Pharmacogenetics of antipsychotic treatment:lessons learned from clozapine显示文摘 | MASELLIS M BASILE VS OZDEMIR V | 2000 | Biol Psychiatry2000，47，3： | 1 |
| 14 | Association of the Mscl polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia 显示文摘 | Basile V Masellis M Badri F | 1999 | Neuropsychopharmacology1999，21，1： | 1 |
| 15 | Darcian preferential water flow and solute transport through bimodal porous systems:experiments and modelling显示文摘 | COPPOLA A COMEGNA V BASILE A | 2009 | Journal of Contaminant Hydrology2009，104，1234： | 1 |
| 16 | Effect of Nose Shape on Three-dimensional Streamlines and Heating Rates显示文摘 | Basil H DeJarnette F R Zoby E V | 1993 | Journal of Spacecraft and Rockets1993，30，1： | 1 |
| 17 | Climate and atmospheric history of the past 420,000 years from the Vostok ice core, Antarctica 显示文摘 | Petit J R Jouzl J Raynaud D Barkov N I Barnola J M Basile I Bender M Chappellaz J Davis M Delay- gue G Delmotte M Kotlyakov V M Legrand M Lipenkov V Y Lorius C Pepin L Ritz C Saltzman E Stievenard M | 1999 | Nature1999，399，6735： | 1 |
| 18 | Specific peroxidase isoenzymes are related with organogenesis显示文摘 | Kay L E Basill K V | 1987 | Plant Physiol1987，84，： | 1 |
| 19 | Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago campestris (Apiaceae)显示文摘 | Basile A Sorbo S Spadaro V | 2009 | Molecules2009，14，3： | 1 |
| 20 | Limits and advanta-ges of abdominal ultrasonography in children with acute appendi-citis syndrome 显示文摘 | Pastore V Cocomazzi R Basile A | 2014 | Afr J Paediatr Surg2014，11，4： | 1 |
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