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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Markers of systemic inflammation and colorectal adenoma risk: Meta-analysis of observational studies显示文摘AIM To perform a meta-analysis of observational studies on inflammatory markers levels and occurrence of colorectal adenoma.METHODS Pub Med and EMBASE databases were searched until March 2016 for the articles reporting on the circulating levels of inflammatory markers, including: C-reactive protein(CRP), interleukin-6(IL-6), and tumor necrosis factor-alpha(TNF-a) and risk of colorectal adenoma. Random-effects models were used to calculate summary odds ratios(ORs) with 95%CIs for the highest vs lowest category of exposure. Heterogeneity was assessed by using the Q test and I2 statistic. Subgroup analyses were also performed to test for potential source of heterogeneity.RESULTS A total of 14 case-control studies were included. Ten studies on CRP including a total of 3350 cases and 4168 controls showed non-significant summary(OR = 1.23, 95%CI: 0.98-1.54; I2 = 54%, P heterogeneity = 0.01) in the general analysis, but significant increased odds when considering only advanced adenoma(OR = 1.59, 95%CI: 1.09-2.32; I2 = 44%, P heterogeneity = 0.15). Subgroup and stratified analyses revealed a potential influence of smoking status and aspirin use on the association between CRP levels and colorectal adenoma. Five studies examined the association between circulating levels of TNF-a and colorectal adenoma risk, including a total of 1,568 cases and 2,832 controls. The summary OR for the highest vs the lowest category of exposure was 1.00(95%CI: 0.77-1.29). The relationship between circulating IL-6 levels and colorectal adenoma risk was investigated in 7 studies including a total of 1936 cases and 3611 controls. The summary OR for the highest vs the lowest category of exposure was 1.19(95%CI: 0.92-1.55).CONCLUSION Summary of current evidence suggests a positive association of CRP levels and advanced colorectal adenoma risk. The role of potential confounding factors should be further evaluated. | Justyna Godos Antonio Biondi Fabio Galvano Francesco Basile Salvatore Sciacca Edward L Giovannucci Giuseppe Grosso | 2017 | World Journal of Gastroenterology2017，23，10： | 5 |
| 3 | 接受纤溶治疗的ST段抬高心肌梗死患者在经皮冠状动脉介入治疗前服用氯吡格雷的效果:PCI-CLARITY研究显示文摘背景:关于经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)前氯吡格雷预治疗的益处目前仍有争议,并且其使用亦未获得普遍认可。
目的:于新近发生ST段抬高心肌梗死(ST—segment elevation myocardial infarction,STEMI)的患者中确定PCI前氯吡格雷预治疗预防严重不良心血管事件的效果是否优于PCI时开始采用氯吡格雷治疗。
设计、地点及参试者:CLARITY(PCI—Clopidogrel as Adjunctive Reperfusion Therapy)研究是一项于1863例患者中进行的前瞻性计划分析。这些患者均于CLARITY—TIMI(Thrombolysis in Myocardial Infarction)28试验中在血管造影后实施了PCI。CLARITY—TIMI28是一项在接受纤溶治疗的患者中进行的有关氯吡格雷效果的随机、双盲、安慰剂对照试验。患者于2003年2月至2004年10月入选自23个国家的319家医院。
干预:患者服用阿斯匹林并于纤溶治疗时开始随机接受氯吡格雷(300mg负荷剂量,以后75mg,每日1次)或安慰剂,直至冠状动脉造影前为止。造影在开始研究药物后2~8天进行。接受冠脉支架的患者建议于诊断性血管造影后给予开标氯吡格雷(包括负荷剂量)。
主要观测指标:一级终点为PCI至随机分组后30天心血管死亡、MI复发或脑卒中的复合发生率。二级终点包括在PCI之前发生的MI或脑卒中以及前述随机分组后30天相关终点。
结果:氯吡格雷预治疗可显著降低PCI后心血管死亡、MI或脑卒中的发生率(34[3.6%]比58[6.2%];校正优势比[odds ratio,OR],0.54[95%CI,0.35—0.85];P=0.008)。氯吡格雷预治疗还可降低PCI前MI或脑卒中的发生率(37[4.0%]比58[6.2%];OR,0.62[95%CI,0.40~0.95];P=0.03)。总体上,氯吡格雷预治疗可导致随机分组后30天心血管死亡、MI或脑卒中显著下降(70[7.5%]比112[12.0%];校正OR,0.59[95%CI,0.43~0.81];P=0.001;所需治疗例数=23)。TIMI严重或轻微出血的发生率未显著增加((18[20%]比17[1.9%];P〉0.99)。
结论:氯吡格雷预治疗可显著降低PCI前后心血管死亡或缺血并发症,而严重或轻微出血无显著增加。这些数据为STEMI患者早期使用氯吡格雷以及接受PCI的患者常规采用氯吡格雷预治疗方案提供了进一步的支持。 | Marc S. Sabatine Christopher P.Cannon C. Michael Gibson Jose L Lopez-Sendon Gilles Montalescot Pierre Theroux Basil S. Lewis Sabina A. Murphy Carolyn H. McCabe Eugene Braunwald 李呈亿(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 2 |
| 4 | Impact of non-ionic surfactant on the long-term development of lab-scale-activated sludge bacterial Communities显示文摘 | Lozada M Basile L Efijman L | 2007 | Research in Microbiology2007，158，829： | 1 |
| 5 | Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study显示文摘 | Pantoni L Poggesi A Basile A M | 2006 | J Am Geriatr Soc2006，54，7： | 1 |
| 6 | Antibacterial activity in Actinidia chinensis, Feijoa sellowiana and Aberia caffra显示文摘 | Basile A Vuotto M L Violante U | 1997 | International Journal of Antimicrobial Agents1997，8，3： | 1 |
| 7 | Surgical strategy for cystic diseases of the liver in a Western Hepatobiliary Center显示文摘 | Basil A J Benjamin L J Phillip C M | 2002 | World J Surg2002，26，4： | 1 |
| 8 | Antimi- crobial and antioxidant activities of Feijoa sellowiana fruit显示文摘 | VUOTYO M L BASILE A MOSCATIELLO V DE SOLE P CASTALDO-COBIANCHI R LAGHIA E IELPO M T L | 2000 | Antimi- crobial Agents2000，13，： | 1 |
| 9 | detection of combustion formed nanopartieles 显示文摘 | Sgro L A Basile G Barone A C | 2003 | Chemosphere2003，，51： | 1 |
| 10 | Family and psychosocial predictors of obsessive--compulsive disorders in a community sample of young adolescents显示文摘 | VALIENI-- BASILE L A GARRISON C Z JACKSON K | 1995 | J Child Family Study1995，4，2： | 1 |
| 11 | Hydraulic conductance of peach trees grafted on rootstocks with different size-controlling potentials显示文摘 | Basile B Marsal J Solari L | 2003 | Journal of Horitcultural Science and Biotechnology2003，，6： | 1 |
| 12 | Thermo - mechanical modeling of laser welding of AA5083 sheets 显示文摘 | Spina R Tricarico L Basile G | 2007 | Journal of Materials Processing Technology2007，191，： | 1 |
| 13 | Acomparison of methods for the measurement of hemodialysisaccess recirculation显示文摘 | BASILE C RUGGIERI G VERNAGLIONE L | 2003 | J Nephrol2003，16，6： | 1 |
| 14 | Immunopharmacological properties of flavonoids显示文摘 | M.T.L Ielpo A Basile R Miranda V Moscatiello C Nappo S Sorbo E Laghi M.M Ricciardi L Ricciardi M.L Vuotto | 2000 | Fitoterapia2000，，： | 1 |
| 15 | Mycobacterium tuberculosis impairs dendritic cell response by altering CDlb, DC-SIGN and MR profile显示文摘 | Balboa L Romero MM Yokobori N Schierloh P Geffner L Basile JI Musella RM Abbate E de la Barrera S Sasiain MC Alemdn M | 2010 | Immunol Cell Biol2010，88，7： | 1 |
| 16 | An experimental study of multilayered composite palladium membrane reactors for partial oxidation of methane to syngas显示文摘 | Basile A Paturzo L | 2001 | Catalysis Today2001，67，123： | 1 |
| 17 | Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people:the LADIS (Leukoaraiosis and Disability in the Elderly) Study显示文摘 | Pantoni L Poqqesi A Basile AM | 2006 | J AM Geriatr2006，54，7： | 1 |
| 18 | Studies on the microbial populations of the rhizosphere of big sagebrush (Artemisia tridentata)显示文摘 | Basil A J Strap J L Knotek-Smith H M | 2004 | J Ind Microbiol Biotechnol2004，31，6： | 1 |
| 19 | Impact of age-related cerebral white matter changes on the transition to disability-the LADIS study:rationale,design and methodology显示文摘 | Pantoni L Basile AM Pracucci G | 2005 | Neuroepidemiology2005，24，12： | 1 |
| 20 | The natural history of auto genous radio-cephalic wrist arteriovenous fistulas of haemodialysis patients: A prospective obserrational study显示文摘 | Basile C Ruqgieri G Vernaglione L | 2004 | Nephrol Dial Transplant2004，19，： | 1 |
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