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| 1 | Consensus statement on the epidemiology,diagnosis,prevention,and management of cow's milk protein allergy in the Middle East:a modified Delphi-based study显示文摘Background This study aimed to develop an expert consensus regarding the epidemiology,diagnosis,and management of cow’s milk protein allergy(CMPA)in the Middle East.Methods A three-step modified Delphi method was utilized to develop the consensus.Fifteen specialized pediatricians participated in the development of this consensus.Each statement was considered a consensus if it achieved an agreement level of>80%.Results The experts agreed that the double-blind placebo-controlled oral challenge test(OCT)should be performed for 2-A weeks using an amino acid formula(AAF)in formula-fed infants or children with suspected CMPA.Formula-fed infants with confirmed CMPA should be offered a therapeutic formula.The panel stated that an extensively hydrolyzed formula(eHF)is indicated in the absence of red flag signs.At the same time,the AAF is offered for infants with red flag signs,such as severe anaphylactic reactions.The panel agreed that infants on an eHF with resolved symptoms within 2-4 weeks should continue the eHF with particular attention to the growth and nutritional status.On the other hand,an AAF should be considered for infants with persistent symptoms;the AAF should be continued if the symptoms resolve within 2-4 weeks,with particular attention to the growth and nutritional status.In cases with no symptomatic improvements after the introduction of an AAF.other measures should be followed.The panel developed a management algorithm,which achieved an agreement level of 90.9%.Conclusion This consensus document combined the best available evidence and clinical experience to optimize the management of CMPA in the Middle East. | Moustafa A.El-Hodhod Mortada H.F.El-Shabrawi Ahmed AIBadi Ahmed Hussein AM Almehaidib Basil Nasrallah Ebtsam Mohammed AIBassam Hala El Feghali Hasan M.Isa Khaled Al Saraf Maroun Sokhn Mehdi Adeli Najwa Mohammed Mousa Al-Sawi Pierre Hage Suleiman Al-Hammadi | 2021 | World Journal of Pediatrics2021，17，6： | 3 |
| 2 | S-100 protein and neuron-specific enolase as markers of subclinical cerebral damage after cardiac surgery:preliminary observation of a 6-month follow-up study显示文摘 | Basile AM Fusi C Conti AA | 2001 | Eur Neurol2001，45，3： | 1 |
| 3 | Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people:the LADIS (Leukoaraiosis and Disability in the Elderly) Study显示文摘 | Pantoni L Poqqesi A Basile AM | 2006 | J AM Geriatr2006，54，7： | 1 |
| 4 | S-100 protein and neuron specific enolase as markers of subclinical cerebral damage after cardiac surgery: preliminary observation of a 6-month follow-upstudy显示文摘 | Basile AM Fusi C Conti AA | 2001 | Eur Neurol2001，45，3： | 1 |
| 5 | Impact of age-related cerebral white matter changes on the transition to disability-the LADIS study:rationale,design and methodology显示文摘 | Pantoni L Basile AM Pracucci G | 2005 | Neuroepidemiology2005，24，12： | 1 |
| 6 | S-100 protein and neuron- specific enolase as markers of subclinical cerebral damage after car- diac surgery: preliminary observation of a 6-month follow-up study 显示文摘 | Basile AM Fusi C Conti AA | 2001 | Eur Neurol2001，45，3： | 1 |
| 7 | S-100 protein and neuron specific enolase as markers of subclinical cerebral damage after cardiac surgery: preliminary observation of a 6-month follow-up study显示文摘 | Basile AM Fusi C Conti AA | 2001 | Eur Neurol2001，45，3： | 1 |
| 8 | Age,hypertension and lacunar stroke are the major determinants of the severity of age-related white matter changes the LADIS(1eukoaraiosis and disability in the elderly study)显示文摘 | Basile AM Pantoni I Pracucci G | 2006 | Cerebrovasc Dis2006，21，： | 1 |
| 9 | Leukoaraios is predicts hidden global functioning impairment in nondisabled older people:the LADIS (Leukoaraiosis and Disability in the Elderly) Study显示文摘 | Pantoni L Poggesi A Basile AM | | 0，，07： | 1 |
| 10 | Abulia and cognitiveimpairment in two patients with capsular genu infarct 显示文摘 | Pantoni IL Basile AM Romanelli M | 2001 | Acta Neu-rol Scand2001，104，3： | 1 |
| 11 | S-100 protein and neuron-specific enolase as markers of subclinical cerebral damage after cardiac surgery:preliminary observation of a 6-month follow-up study显示文摘 | BASILE AM FUSI C CONTI AA | 2001 | Eur Neurol2001，45，3： | 1 |
| 12 | Impact of age-related cere- bral white matter changes on the transition to disability - the LADIS study: rationale, design and methodology 显示文摘 | Pantoni L Basile AM Pracueci G | 2005 | Neuroepidemiology2005，24，12： | 1 |
| 13 | Impact of age-related cerebral white matter changes on the transition to disabilitythe LADIS study: rationale, design and methodology 显示文摘 | Pantoni L Basile AM Pracucci G | 2005 | Neuroepidemiology2005，24，12： | 1 |
| 14 | S-100 protein and neuron-specific enolase as markers of subclinical cerebral damage after cardiac surgery:preliminary observation of a 6-month follow-up study显示文摘 | Basile AM Fusic C Conti AA | 2001 | Eur Neurol2001，45，3： | 1 |
| 15 | Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes the LADIS(leukoaraiosis and disability in the elderly)study显示文摘 | Basile AM Pantoni L Pracucci G | 2006 | Cerebrovasc Dis2006，21，56： | 1 |
| 16 | Age,hypertension,and lacunar stroke are the major determinants of the severity of age-related white mat-ter changes the LADIS(leukoaraiosis and disability in the elderly)study显示文摘 | Basile AM Pantoni L Pracucci G | 2006 | Cerebrovasc Dis2006，21，56： | 1 |
| 17 | Age, hypertension,and lacunar stroke are the major determinants of the severity of age-related white matter changes the LADIS (leukoaraiosis and disability in the elderly)study显示文摘 | Basile AM Pantoni L Pracucci G | 2006 | Cerebrovasc Dis2006，21，： | 1 |
| 18 | Leukoaraiosis pre- dicts hidden global functioning impairment in nondisabled ol- der people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study 显示文摘 | Pantoni L Poqqesi A Basile AM | 2006 | J AM Geriatr Soc2006，54，7： | 1 |
| 19 | Abulia and cognitive impairment in two patients with capsular genu infarct 显示文摘 | Pantoni L Basile AM Romanelli M | 2001 | Acta Neurol Scand2001，104，3： | 1 |
| 20 | Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study显示文摘 | Pantoni L Poqqesi A Basile AM | 2006 | J Am Geriatr Soc2006，54，7： | 1 |
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