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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insu- lin secretion显示文摘 | Gonzalez- Barroso MM Giurgea I Bouillaud F | 2008 | PLuS One2008，3，12： | 1 |
| 3 | Do inflammatory markers add predictive information of death beyond that provided by age and comorbidity in chronic renal failure patients显示文摘 | Caravaca F Martin MV Barroso S | 2006 | Nephrel Dial Transplant2006，21，： | 1 |
| 4 | Contribution of different vegetable types to exogenous nitrate and nitrite exposure显示文摘 | Manuela Correia ngela Barroso M Fátima Barroso | 2010 | Food Chemistry2010，120，4： | 1 |
| 5 | Supercritical carbon dioxide extraction of bioactive compounds from microalgae and vola- tile uils from aromatic, plants 显示文摘 | Palavra A M F Coelho J P Barroso J G et at | 2011 | J of Supercritlcal Fluids2011，60，： | 1 |
| 6 | Duplication of a truncated paralog of the family B DNA polymerase gene Aa-polB in the Agrocybe aegerita mitochondrial genome 显示文摘 | Barroso G Bois F Labarere J | 2001 | Appl Environ Microbiol2001，67，4： | 1 |
| 7 | Molecular and kinetic characterization and cell type location of inducible nitric oxide synthase in fish显示文摘 | Barroso J B Carreras A Esteban F J | 2000 | Am Physiol Regul lntegr Comp Physiol2000，279，： | 1 |
| 8 | Constitutive arginine-dependent nitric oxide synthase activity in different organs of pea seedlings during plant development显示文摘 | CORPAS F J BARROSO J B CARRERAS A VALDERRAMA R PALMA J M LEON A M SANDALIO L M DEL RIO L A | 2006 | Planta2006，224，2： | 1 |
| 9 | Peroxisomal NADP-dependent isocitrate dehydrogenase,characterization and activity regulation during natural senescence显示文摘 | CORPOS F J BARROSO J B SANDALIO L M | 1999 | Plant Physiology1999，121，： | 1 |
| 10 | Hydrogen production by ethanol reforming over NiZnA1 catalysts 显示文摘 | Barroso M N Gomez M F Arrua L A | 2006 | Appl Catal A:Gen2006，304，： | 1 |
| 11 | Behavior of a high-capacity steam boiler using heavy fuel oil, part Ⅱ: cold-end corrosion 显示文摘 | Barreras F Barroso J | 2004 | Fuel Processing Technology2004，86，2： | 1 |
| 12 | Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden显示文摘 | Renstrom F Payne F Nordstrom A Brito E C Rolandsson O Hallmans G Barroso I Nordstrom P and Franks P W | | 0，，08： | 1 |
| 13 | Cellular and subcellular localization of endogenous nitric oxide in young and senescent pea plants显示文摘 | CORPAS F J BARROSO J B CARRERAS A | 2001 | Plant Physiology2001，136，： | 1 |
| 14 | Behavior of a high-capacity steam boiler using heavy fuel oil, part Ⅰ: cold-end corrosion 显示文摘 | Barreras F Barroso J | 2004 | Fuel Processing Technology2004，86，2： | 1 |
| 15 | Determination of capsaicinoids in peppers by microwave-assisted extraction-high- performance liquid chromatography with fluorescence detection显示文摘 | BARBERO G F PALMA M BARROSO C G | 2006 | Analvtica Chimica Acta2006，578，2： | 1 |
| 16 | Carbon nanotubes provide self-extinguishing grade to silicone-base foam 显示文摘 | VERDEJO R BARROSO -BUJIANS F RODRIGU- EZ- PEREZ M A | 2008 | J Mater Chem2008，18，： | 1 |
| 17 | Individual and combined effects of triptoreline and gestrinone onexperimental endo- metriosis in rats 显示文摘 | Quereda F Barroso J Acien P | 1996 | Eur J Obstet Gynecol Reprod Biol1996，67，1： | 1 |
| 18 | Determination of capsaicinoids in peppers by microwave - assisted extraction - high - performance liquid chromatography with fluorescence detection 显示文摘 | Barbero G F Palma M Barroso C G | 2006 | Analytica Chimica Acta2006，578，2： | 1 |
| 19 | The effect of zinc supplementation on linear growth, body composition, and growth factors in preterm infants 显示文摘 | Diaz-Gomez NM Domeneeh E Barroso F | 2003 | Pediatrics2003，111，51： | 1 |
| 20 | Study of fatigue damage in wind turbine blades显示文摘 | MARIN J C BARROSO A PARIS F | 2009 | Engineering Failure Analysis2009，16，2： | 1 |
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