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	题名	作者	年代	出处	被引量
1	SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases.	Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera	2020	Signal Transduction and Targeted Therapy2020，5，1：	7
2	Factors affecting secondary metabolite production in plants: Volatile components and essential oils 显示文摘	Figueiredo A C Barroso J G Pedro L G	2008	Flavour Fragr J2008，23，4：	1
3	Web search for a planet: The Google cluster architecture显示文摘	Barroso L A Dean J Holzle U	2003	IEEE Micro2003，23，2：	1
4	Preserved ex vivo inflammatory status in decidual cells from women with pre- term labor and subclinical intrauterine infection 显示文摘	Castro-Leyva V Espejel-Nuilez A Barroso G	2012	PLoS 0ne2012，7，43：	1
5	High FSH:LH ratio and low LH levels in basal cycle day 3: impact on follicular development and IVF outcome显示文摘	Barroso G Oehninger S Monz6 A	2001	J Assist Reprod Genet2001，18，：	1
6	High FSH : LH ratio and low LH levels in basal cycle day 3: impact on follicular development and IVF outcome显示文摘	Barroso G Oehninger S Monzo A	2001	J Assist Reprod Genet2001，18，9：	1
7	Web search for a planet: the googlecluster architecture 显示文摘	Barroso L A Dean J Holzle U	2003	IEEE Micro2003，232，：	1
8	Supercritical carbon dioxide extraction of bioactive compounds from microalgae and vola- tile uils from aromatic, plants 显示文摘	Palavra A M F Coelho J P Barroso J G et at	2011	J of Supercritlcal Fluids2011，60，：	1
9	The price of performance显示文摘	Barroso L A	2005	Queue2005，3，7：	1
10	Prediction of welding residual stresses and displacements by slmplified models显示文摘	Barroso A Cans J Pic6n R		Mate''rials and Design0，，3：	1
11	Time-of-use tariff design under uncertainty in price-elasticities of electricity demand: A stochastic optimization approach 显示文摘	DE Sa FERREIRA R BARROSO L A LINO P R	2013	IEEE Transactions on Smart Grid2013，4，4：	1
12	The datacenter as a computer-an introduction to the design of warehouse-scale machines显示文摘	BARROSO L A HOLZLE U	2009	Synthesis Lectures on Computer Architecture2009，8，3：	1
13	The Role of Cobalt Phosphate in Enhancing the Photocatalytic Activity of a-Fe203 toward Water Oxidation显示文摘	Barroso M Cowan A J Pendlebury S R	2011	Journal of the American Chemical So- ciety2011，133，14：	1
14	Use of rituximab as a salvage therapy for HIV-assoeiated multicentric Castleman disease 显示文摘	Casquero A Barroso A Ferandez Guerrero ML	2006	Ann Hematol2006，85，3：	1
15	Molecular and kinetic characterization and cell type location of inducible nitric oxide synthase in fish显示文摘	Barroso J B Carreras A Esteban F J	2000	Am Physiol Regul lntegr Comp Physiol2000，279，：	1
16	Short-term stability of soy isoflavones extracts: sample conservation aspects 显示文摘	Rostagno M A Palma M Barroso C G	2005	Food Chemistry2005，173，：	1
17	Web Search for a Planet: The Google Cluster Architecture 显示文摘	Barroso L A Dean J Holzle U	2003	IEEE Micro2003，23，2：	1
18	Mechanical behavior and microstructural analysis of alumina-titanium brazed interfaces显示文摘	NONO M C A BARROSO J J CASTRO P J	2006	Mat Sci Eng A2006，，5：	1
19	Ultrasound-assisted extraction of soy isoflavones显示文摘	Mauricio A Rostagno Miguel Palma Carmelo G Barroso	2003	Ultrasonics Sonochemistry2003，1012，：	1
20	Failure Trends in a Large Disk Drive Population显示文摘	PINHEIRO E WEBER W D BARROSO L A	2007	Proceedings of the 5th USENIX Conference on File and Storage Technologies (FAST''07)2007，，：	1

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