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| 1 | 外科手术中产生的烟气:仅仅是大量的热空气吗?显示文摘外科医生和手术室人员经常接触手术设备产生的烟气,病人也会暴露于烟气中,特别是腹腔镜手术中产生的烟气滞留于腹腔内这一密闭空间并被吸收。这些烟气是一种与香烟烟气相似的毒性物质,然而对这种毒性物质的影响还未引起足够重视。应该采取必要措施尽可能减少手术中烟气的不良影响。 | Barrett WL Garber SM 黄文海 朱江帆(摘译) | 2005 | 中国微创外科杂志2005，5，4： | 17 |
| 2 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 3 | Satellite remote sensing of grasslands:from observation to management显示文摘Aims Grasslands are the world’s most extensive terrestrial ecosystem,and are a major feed source for livestock.Meeting increasing demand for meat and other dairy products in a sustainable manner is a big challenge.At a field scale,Global Positioning System and ground-based sensor technologies provide promising tools for grassland and herd management with high precision.With the growth in availability of spaceborne remote sensing data,it is therefore important to revisit the relevant methods and applications that can exploit this imagery.In this article,we have reviewed the(i)current status of grassland monitoring/observation methods and applications based on satellite remote sensing data,(ii)the technological and methodological developments to retrieve different grassland biophysical parameters and management characteristics(i.e.degradation,grazing intensity)and(iii)identified the key remaining challenges and some new upcoming trends for future development.Important Findings The retrieval of grassland biophysical parameters have evolved in recent years from classical regression analysis to more complex,efficient and robust modeling approaches,driven by satellite data,and are likely to continue to be the most robust method for deriving grassland information,however these require more high quality calibration and validation data.We found that the hypertemporal satellite data are widely used for time series generation,and particularly to overcome cloud contamination issues,but the current low spatial resolution of these instruments precludes their use for field-scale application in many countries.This trend may change with the current rise in launch of satellite constellations,such as RapidEye,Sentinel-2 and even the microsatellites such as those operated by Skybox Imaging.Microwave imagery has not been widely used for grassland applications,and a better understanding of the backscatter behaviour from different phenological stages is needed for more reliable products in cloudy regions.The development of hyperspectral satellite instrumentation and analytical methods will help for more detailed discrimination of habitat types,and the development of tools for greater end-user operation. | Iftikhar Ali Fiona Cawkwell Edward Dwyer Brian Barrett Stuart Green | 2016 | Journal of Plant Ecology2016，9，6： | 15 |
| 4 | 定量药理学:一个促进药物开发及转换型研究严谨思考的多学科领域显示文摘尽管从事定量药理学研究的科学工作者一再强调将定量分析的原则应用于促进新药研发的决策,定量药理学的发展还是超过了上述领域。普通研究和决策领域总是期望着常规和传统的研究范例发生进步,当与定量药理学相关的领域自身在发展并与其交互作用时,自然便产生对临床药理学的协同作用。创新性和可塑性训练计划和策略均是将来临床研究工作中必不可少的要素。掌握定量药理学领域的知识成为对药理科学家的要求,具有定量药理学背景的人员可望获得更高的薪水。目前定量药理学相关培训计划,教学资料,及学术权威均比较贫乏,学生们可以从企业化、调控性的背景的教师等多种机构的教职员那获得指导,此外也可以通过在线课程,可视化教学进修课程,与他们的导师保持联系。对课程和学位的管理可以采取灵活的态度,这样可在短期内培养更多的定量药理学工作者。 | Jeffrey S Barrett Michael J Fossler K.David Cadieu Marc R Gastonguay 沈杰 谢海棠 孙瑞元 | 2008 | 中国临床药理学与治疗学2008，13，5： | 10 |
| 5 | Specific shRNA targeting of FAK influenced collagen metabolism in rat hepatic stellate cells显示文摘AIM:To investigate the effects and mechanism of disruption of focal adhesion kinase(FAK) expression on collagen metabolism in rat hepatic stellate cells(HSC).METHODS:The plasmids expressing FAK short hairpin RNA(shRNA) were transfected into HSC-T6 cells,and the level of FAK expression was determined by both real-time quantitative polymerase chain reaction(QPCR) and Western blotting analysis.The production of type collagen and type collagen in FAK-disrupted cells was analyzed by real-time Q-PCR.The level of collagen metabolism proteins,including matrix metalloproteinases-13(MMP-13) and tissue inhibitors of metalloproteinases-1(TIMP-1) was also determined by both real-time Q-PCR and Western blotting analysis.RESULTS:The transfection of FAK shRNA plasmids into HSC resulted in disrupted FAK expression.Compared with the HK group,the levels of type collagen and type collagen mRNA transcripts in FAK shRNA plas-mid group were signif icantly decreased(0.69 ± 0.03 vs 1.96 ± 0.15,P = 0.000;0.59 ± 0.07 vs 1.62 ± 0.12,P = 0.020).The production of TIMP-1 in this cell type was also signif icantly reduced at both mRNA and protein levels(0.49 ± 0.02 vs 1.72 ± 0.10,P = 0.005;0.76 ± 0.08 vs 2.31 ± 0.24,P = 0.000).However,the expression of MMP-13 mRNA could be significantly up-regulated by the transfection of FAK shRNA plasmids into HSC(1.74 ± 0.20 vs 1.09 ± 0.09,P = 0.000).CONCLUSION:These data support the hypothesis that shRNA-mediated disruption of FAK expression could attenuate extracellular matrix(ECM) synthesis and promote ECM degradation,making FAK a potential target for novel anti-f ibrosis therapies. | Zhi-Na Dun Xiao-Lan Zhang Jun-Yan An Li-Bo Zheng Robert Barrett Shu-Rui Xie | 2010 | World Journal of Gastroenterology2010，16，32： | 8 |
| 6 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 7 | New insights into the pathogenesis of intestina dysfunction:secretory diarrhea and cystic fibrosis显示文摘INTRODUCTIONA major function of the intestinal epithelium is to controlthe amount of fluid entering into and being absorbed fromthe lumen.In healthy conditions,net fluid movementfollows an absorptive vector,although significant secretionalso takes place to subserve digestive function.Thus。 | Kim E. Barrett | 2000 | World Journal of Gastroenterology2000，6，4： | 5 |
| 8 | 儿童临床试验设计在药物研发和评估中的应用显示文摘儿童具有生长和发育两个特点,其个体发育包括药物代谢酶、转运蛋白、受体和器官的发育。儿童的生长和发育使得药物的吸收、分布、代谢和排泄及药物在儿童的不同发育阶段对发育中器官的药效都存在着与成人显著不同的差异。 | Di Wu 申昆玲 王晓玲 曹进 Jeffrey S. Barrett | 2011 | 中华儿科杂志2011，49，12： | 5 |
| 9 | Malaria: Global progress 2000-2015 and future challenges显示文摘Background:2015 was the target year for malaria goals set by the World Health Assembly and other international institutions to reduce malaria incidence and mortality.A review of progress indicates that malaria programme financing and coverage have been transformed since the beginning of the millennium,and have contributed to substantial reductions in the burden of disease.Findings:Investments in malaria programmes increased by more than 2.5 times between 2005 and 2014 from US$960 million to US$2.5 billion,allowing an expansion in malaria prevention,diagnostic testing and treatment programmes.In 2015 more than half of the population of sub-Saharan Africa slept under insecticide-treated mosquito nets,compared to just 2%in 2000.Increased availability of rapid diagnostic tests and antimalarial medicines has allowed many more people to access timely and appropriate treatment.Malaria incidence rates have decreased by 37%globally and mortality rates by 60%since 2000.It is estimated that 70%of the reductions in numbers of cases in sub-Saharan Africa can be attributed to malaria interventions.Conclusions:Reductions in malaria incidence and mortality rates have been made in every WHO region and almost every country.However,decreases in malaria case incidence and mortality rates were slowest in countries that had the largest numbers of malaria cases and deaths in 2000;reductions in incidence need to be greatly accelerated in these countries to achieve future malaria targets.Progress is made challenging because malaria is concentrated in countries and areas with the least resourced health systems and the least ability to pay for system improvements.Malaria interventions are nevertheless highly cost-effective and have not only led to significant reductions in the incidence of the disease but are estimated to have saved about US$900 million in malaria case management costs to public providers in sub-Saharan Africa between 2000 and 2014.Investments in malaria programmes can not only reduce malaria morbidity and mortality,thereby contributing to the health targets of the Sustainable Development Goals,but they can also transform the well-being and livelihood of some of the poorest communities across the globe. | Richard E.Cibulskis Pedro Alonso John Aponte Maru Aregawi Amy Barrette Laurent Bergeron Cristin A.Fergus Tessa Knox Michael Lynch Edith Patouillard Silvia Schwarte Saira Stewart Ryan Williams | 2016 | Infectious Diseases of Poverty2016，5，1： | 4 |
| 10 | Emerging and re -emerging infectious diseases: the hird epidemiolngic transition显示文摘 | BARRETT R KUZAWA C W MCDADE T | 1998 | Ann Rev Anthropol1998，27，： | 3 |
| 11 | Forkhead domain mutations in FOXA1 drive prostate cancer progression显示文摘Dear Editor,F0XA1 (Forkhead Box Protein A1)is a pioneer transcription factor (TF) that functions to loosen the compact chromatin structure to facilitate binding of other TFs such as estrogen receptor and androgen receptor (AR).1,2 AR is a nuclear receptor functioning as a ligand-dependent TF that plays a pivotal role in driving the initiation of prostate cancer (Pca) and the development of castration-resistant Pca (CRPC). | Shuai Gao Sujun Chen Dong Han David Barrett Wanting Han Musaddeque Ahmed Susan Patalano Jill A. Macoska Housheng Hansen He Changmeng Cai | 2019 | Cell Research2019，29，9： | 3 |
| 12 | Chimeric Antigen Receptor Therapy for Cancer显示文摘 | David M. Barrett Nathan Singh David L. Porter Stephan A. Grupp Carl H. June | 2014 | Annual Review of Medicine2014，，： | 3 |
| 13 | ACCR导线的现场试验显示文摘ACCR导线是种新型导线,它看上去与传统的ACSR基本相同,但它是由合成材料和耐热铝合金组成。它的主要特点是高强度、重量轻(钢芯的1/3),良好的传导性能(钢芯的3倍)以及热膨胀系数低(钢芯的1/2),因此可以在低弛度重量大线段替代钢导线。美国在2个不同地点对这种新型导线进行现场试验,以验证其各种性能。 | H. E. DEVE R. CLARK J. STOVALL S. BARRETT R. WHAPHAM W. UESNEL 马明(编译) | 2007 | 电力建设2007，28，4： | 3 |
| 14 | Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals?显示文摘 | Jacqueline S. Barrett Peter R. Gibson | 2012 | Therapeutic Advances in Gastroenterology2012，，4： | 3 |
| 15 | Allocating ecological footprints to final consumption categories with input–output analysis显示文摘 | Thomas Wiedmann Jan Minx John Barrett Mathis Wackernagel | 2005 | Ecological Economics2005，，1： | 2 |
| 16 | Probiotics and Commensals Reverse TNF-α– and IFN-γ–Induced Dysfunction in Human Intestinal Epithelial Cells显示文摘 | Silvia Resta–Lenert Kim E. Barrett | 2006 | Gastroenterology2006，，3： | 2 |
| 17 | Differential function of intestinal intraepithelial lymphocyte subsets 显示文摘 | Barrett TA Gajewskj D Danielpour EB | 1992 | J Immunol1992，149，4： | 2 |
| 18 | Perforated jejunal ulcer associated with gastric mucosa in a jejunal diverticulum显示文摘Jejunal diverticula are rare and subsequent complications even more so. The usual small bowel diverticulum encountered by general surgeons is a Meckel's. These are embryological remnants of the vitello-intestinal duct and are on the anti-mesenteric surface of the terminal ileum. They may contain heterotopic gastric or pancreatic mucosa. Herein we explore the case of a young girl who presented with features of peritonitis secondary to a complication from a jejunal diverticulum. The case, pathology, complications and treatment of jejunal diverticulosis and heterotopic gastric mucosa in the jejunum are explored. | John Bunni Helen L Barrett Tim A Cook | 2014 | World Journal of Clinical Cases2014，2，6： | 2 |
| 19 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 20 | The threat of peste des petits ruminants: progress in vaccine development for disease control显示文摘 | A. Diallo C. Minet C. Le Goff G. Berhe E. Albina G. Libeau T. Barrett | 2007 | Vaccine2007，，30： | 2 |
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