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| 1 | Plant geranylgeranyl diphosphate synthases: every (gene) family has a story显示文摘Plant isoprenoids(also known as terpenes or terpenoids)are a wide family of primary and secondary metabolites with multiple functions.In particular,most photosynthesis-related isoprenoids(including carotenoids and chlorophylls)as well as diterpenes and polyterpenes derive from geranylgeranyl diphosphate(GGPP)produced by GGPP synthase(GGPPS)enzymes in several cell compartments.Plant genomes typically harbor multiple copies of differentially expressed genes encoding GGPPS-like pro-teins.While sequence comparisons allow to identify potential GGPPS candidates,experimental evidence is required to ascertain their enzymatic activity and biologi cal function.Actually,functional analyses of the full set of potential GGPPS paralogs are only available for a handful of plant species.Here we review our current knowledge on the GGPPS families of the model plant Arabidopsis thaliana and the crop species rice(0ryza sativa),pepper(Capsicum annuum)and tomato(Solanum lycopersicum).The results indicate that a major determinant of the biological role of particular GGPPS paralogs is the expression profile of the corresponding genes even though specific interactions with other proteins(including GGPP-consuming enzymes)might also contribute to subfunctionalization.In some species,however,a single GGPPS isoforms appears to be responsible for the production of most if not all GGPP required for cell functions.Deciphering the mechanisms regulating GGPPS activity in particular cell compartments,tissues,organs and plant species will be very useful for future metabolic engineering approaches aimed to manipulate the accumulation of particular GGPP-derived products of interest without negatively impacting the levels of other isoprenoids required to sustain essential cell functions. | M.Victoria Barja Manuel Rodriguez-Concepcion | 2021 | aBIOTECH2021，2，3： | 4 |
| 2 | Dietary Vitamin C decrease endogenous protein exidative damage, malondialdehyde, and lipid peroxidation and maintains fatty acid unsaturation in the guinea pig liver显示文摘 | Barja G Lopez-Tcrres M Perez-Campo R | 1996 | Free Radio Biol Med1996，17，： | 1 |
| 3 | Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA dama~induced by the kidney carcinogen KBrO3显示文摘 | CADENAS S BARJA G | 1999 | Free Rasic Biol Med1999，26，1112： | 1 |
| 4 | The plantaris tendon graft:an ultrasound study显示文摘 | Simpson SL Hertzog MS Barja RH | 1991 | J Hand Surg Am1991，16，： | 1 |
| 5 | Design and implementation of rock & roll:A deductive object-oriented database system显示文摘 | Maria L Barja Alvaro A A Fernandes Norman W Paton | 1995 | Information System1995，20，3： | 1 |
| 6 | Microcalorimetric measurements of the influence of glucose concentration on microbial activity in soils 显示文摘 | Barja I Nunez L | 1999 | Soil Biol Biochem1999，31，： | 1 |
| 7 | Free radicals and aging显示文摘 | Barja G | 2004 | Trends Neurosci2004，27，10： | 1 |
| 8 | Plasmids and factors associated with virulence in environmental isolates of Vibrio cholerae non-O1 in Bangladesh 显示文摘 | Santos Y Huq I | 1990 | J Med Microbiol1990，33，2： | 1 |
| 9 | Effect of storage of soil at 4oC on the microbial activity studied by microcalorimetry 显示文摘 | Nuez-Regueira L Barros N Barja L | 1994 | J Therm Anal Calorim1994，41，： | 1 |
| 10 | Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals显示文摘 | Barja G Herrem A | 2000 | FASEB J2000，14，2： | 1 |
| 11 | Microcalorimetric study of the effect of temperature on microbial activity in soil 显示文摘 | Barja MI Proupin J Nunez L | 1997 | Thermochim Acta1997，303，： | 1 |
| 12 | Free radicals and aging 显示文摘 | Barja G | 2004 | Trends Neurosci2004，27，10： | 1 |
| 13 | Antibiotic activity of epiphytic bacteria isolated from intertidal seaweeds显示文摘 | Toranzo AE Barja JL | 1986 | Microb Ecol1986，，11： | 1 |
| 14 | Proteome analysis of Acetobacter pasteurianus during acetic acid fermentation显示文摘 | Andrés-Barrao C Saad MM Chappuis ML Boffa M Perret X Pérez RO Barja F | | 0，，06： | 1 |
| 15 | Free Radicals and Aging 显示文摘 | BARJA G | 2004 | Trends Neurosci2004，27，10： | 1 |
| 16 | Oxidative damage to mitochondrial DNA is in-versely related to maximum life span in the heart and brain ofmammals显示文摘 | Barja G Herrero A | 2010 | Faseb J2010，14，02： | 1 |
| 17 | Antibiotic activity of epiphytic bacteria isolated from intertidal sea- weeds显示文摘 | Lemos M L Toranzo A E Barja J L | 1985 | Microb Ecol1985，11，： | 1 |
| 18 | Ulcerative skin and fin lesions in reared turbot,Scophthalmus maximus显示文摘 | Devesa S Barja J L Toranzo A E | 1989 | Journal of Fish Diseases1989，，12： | 1 |
| 19 | Rate of generation of oxidative stress-related damage and animal longevity显示文摘 | BARJA G | 2002 | Free Radic Biol Med2002，33，： | 1 |
| 20 | First report of vibriosis in turbot (Scophthalmus maximus) cultured in North- western Spain显示文摘 | Devesa S Toranzo A E Barja J I | 1985 | Fish and Shellfish Pathology1985，，1： | 1 |
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