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| 1 | Real-time high-resolution mid-infrared optical coherence tomography显示文摘The potential for improving the penetration depth of optical coherence tomography systems by using light sources with longer wavelengths has been known since the inception of the technique in the early 1990s.Nevertheless,the development of mid-infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region,resulting in slow acquisition,low sensitivity,and poor axial resolution.In this work,a mid-infrared spectral-domain optical coherence tomography system operating at a central wavelength of 4μm and an axial resolution of 8.6μm is demonstrated.The system produces two-dimensional cross-sectional images in real time enabled by a high-brightness 0.9-to 4.7-μm mid-infrared supercontinuum source with a pulse repetition rate of 1 MHz for illumination and broadband upconversion of more than 1-μm bandwidth from 3.58–4.63μm to 820–865 nm,where a standard 800-nm spectrometer can be used for fast detection.The images produced by the mid-infrared system are compared with those delivered by a state-of-the-art ultra-high-resolution near-infrared optical coherence tomography system operating at 1.3μm,and the potential applications and samples suited for this technology are discussed.In doing so,the first practical mid-infrared optical coherence tomography system is demonstrated,with immediate applications in real-time non-destructive testing for the inspection of defects and thickness measurements in samples that exhibit strong scattering at shorter wavelengths. | Niels M.Israelsen Christian R.Petersen Ajanta Barh Deepak Jain Mikkel Jensen Gunther Hannesschlager Peter Tidemand-Lichtenberg Christian Pedersen Adrian Podoleanu Ole Bang | 2019 | Light(Science & Applications)2019，8，1： | 7 |
| 2 | Morphology and adsorbate dependence of ionic transport in dye sensitized nesoporous TiO2 films显示文摘 | Papageorgiou N Barhe'c Gratzel M | 1996 | J Phys Chem B1996，44，： | 1 |
| 3 | Desertification in the eastern province of Saudiu Arabia显示文摘 | Barh H | 1999 | Journal of Arid Environments1999，43，4： | 1 |
| 4 | Microma let-7 : An emerging next-generation cancer therapeutic 显示文摘 | Barh D Malhotra R Ravi B | 2010 | Curr Oncol2010，17，1： | 1 |
| 5 | Microrna let-7:an emer-ging next-generation cancer therapeutic显示文摘 | Barh D Malhotra R Ravi B | 2010 | Current Oncolo- gy2010，17，1： | 1 |
| 6 | MicroRNA let-7: an emerging next-generation cancer therapeutic 显示文摘 | Barh D Malhotra R Ravi B | 2010 | Curr Oncol2010，17，1： | 1 |
| 7 | MicroRNA let-7 an emerging next-generation cancer therapeutic 显示文摘 | Barh D Malhotra R Ravi B | 2010 | Curr Oncol2010，17，1： | 1 |
| 8 | Microrna let-7:an emerging next generation cancer therapeutic显示文摘 | Barh D Malhotra R Ravi B | | 0，，： | 1 |
| 9 | Let-7,miR-125,miR-205,and miR-296 are prospective therapeutic agents in breast cancer molecular medicine显示文摘 | Barh D Parida S Parida BP | | 0，，： | 1 |
| 10 | Molecular features,markers,drug targets,and prospective targeted therapeutics in cardiac myxoma显示文摘 | BARH D KUMAR A CHATTERJEE S | 2009 | Curr Cancer Drug Targets2009，9，6： | 1 |
| 11 | Molecular features,markers,drug targets,and prospective targeted therapeutics in cardiac myxoma显示文摘 | Barh D Kumar A Chatteriee S | | 0，，06： | 1 |
| 12 | Molecular features, markers, drug targets, and prospective targeted therapeutics in cardiac myxoma显示文摘 | Barh D Kunaar A Chatteriee S | 2009 | Curr Cancer Drug Tarqets2009，9，6： | 1 |
| 13 | Microrna let 7:an emerging next-generation cancer therapeutic 显示文摘 | Barh D Malhotra R Ravi B | 2010 | Curr Oncol2010，17，1： | 1 |
| 14 | m6A修饰酶METTL16在卵巢中的表达及其作用机理挖掘显示文摘目的基于公共数据库挖掘m6A修饰酶METTL16在卵巢癌中的表达及其作用机制,为进一步研究METTL16在卵巢癌中作用及机理提供理论依据。方法收集Oncomine数据库METTL16基因表达信息,分析其在卵巢癌中的表达。利用Kaplan-Meier数据库分析METTL16基因与卵巢癌患者生存的关系。通过STRING数据库研究METTL16基因相关蛋白网络,在Metascape数据库进行其相关蛋白功能富集分析,挖掘其可能的机理。结果Oncomine数据库中关于卵巢癌METTL16基因的相关研究显示,与正常组比较,METTL16在卵巢癌中呈现低表达,差异有统计学意义(P<0.05),通过Kaplan-Meier生存分析发现,METTL16基因低表达组无病生存率明显高于高表达组(P=0.00024)。通过STRING数据库收集到YTHDC1主要相关蛋白有MEPCE,SGSM2,CLUH,METTL14,SRR,BRMS1L,SMG6,DCP1B,RBM34,METTL3等10个。以上蛋白主要富集在RNA甲基化和mRNA分解代谢过程。结论METTL16在卵巢癌中低表达,其可能通过结合并甲基化mRNA和snRNA干预mRNA分解代谢过程,同时通过与METTL3互作蛋白相互拮抗。METTL16作为新近证实的一种m6A RNA甲基转移酶,其在卵巢癌中的作用机制、临床意义等,还需要进一步的实验来验证。 | Abdelkerim Barh Touna 董莹 杨志新 杨丽华 | 2022 | 云南医药2022，43，2： | 0 |
| 15 | 基于Oncomine数据库研究PDE4D基因在卵巢癌中的表达及血根碱的调控作用显示文摘目的通过深度挖掘Oncomine数据库中PDE4D在卵巢癌的研究数据,分析PDE4D基因在卵巢癌中的表达变化,并进行细胞实验研究血根碱对卵巢癌细胞中PDE4D基因表达的影响。方法PharmMapper数据库查询与血根碱药效基团匹配的作用靶点,收集Oncomine数据库PDE4D在卵巢癌中的研究数据,进一步分析PDE4D在卵巢癌中的表达变化。将卵巢癌SKOV3和A2780细胞分成对照组和血根碱组,CCK8和RTqPCR法分别检测血根碱对卵巢癌A2780、SKOV3细胞增殖及PDE4D mRNA表达的影响。结果PDE4D是与血根碱药效基团匹配的作用靶点。Oncomine数据库中共查询到6项正常卵巢组织和卵巢癌组织PDE4D基因的研究,且PDE4D在不同类型的卵巢癌组织中均呈高表达(P<0.05)。细胞实验表明,与对照组相比,血根碱组卵巢癌A2780、SKOV3细胞增殖被明显抑制,PDE4D mRNA表达降低,差异均有统计学意义(P<0.05)。结论卵巢癌组织中PDE4D基因呈高表达,血根碱抑制卵巢癌细胞生长可能与下调PDE4D表达相关。 | 邓玥 邹丹 Touna Abdelkerim Barh 杨丽华 | 2022 | 昆明医科大学学报2022，43，3： | 0 |
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