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		题名	作者	年代	出处	被引量
	1	GENETIC INSTABILITY IN CERVICAL CARCINOMA显示文摘Objective: The role of human papillomavirus (HPV) in the development of cervical carcinoma has been clearlyestablished but other factors could be involved in cervicaltumorigenesis such as loss of heterozygosity (LOH) andmicrosatellite instability (MI). The aim of the present study was to investigate the genetic instability in cervicalcarcinoma tissues and provide evidence for discovering new tumor suppressor genes and screening diagnostic molecular marker of cervical carcinoma. Methods: Fifty primarycervical carcinoma samples from high-incidence area were analyzed by PCR for HPV16 infection, LOH andmicrosatellite instability. Results: HPV16 was detected in88% of the cases. Sixty-six percent of total cases showed LOH with no more than 3 different loci per case. Thehighest frequency of the allelic loss was found in D18S474 (18q21, 40.5%). MI was detected in 4 cases (8%) only.Conclusion: Different percentages of LOH on specificchromosomal regions were found and MI was veryinfrequent in cervical carcinoma. The putative suppressorgene(s) could be located on specific chromosome regionssuch as 18q, and genetic instability could be involved in cervical tumorigenesis.	赵旻伍欣星邱小萍李晖戴天力谭云	2002	Chinese Journal of Cancer Research2002，14，4：	0
	2	基因标记物在头颈部肿瘤中的应用显示文摘基因标记物在临床已有许多研究与应用。本文综述了近年来基因标记物在头颈部肿瘤中早期诊断、精确分期及判断预后等方面的应用研究。	白守民梁碧玲崔念基	2001	国外医学(肿瘤学分册)2001，28，3：	0

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