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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Thermal Frontiers in the Design and Packaging Microelectronic Equipment显示文摘 | Cohen A Bar Kraus A D Davidson S F | 1983 | Mechanical Engineering1983，105，6： | 1 |
| 3 | Pathology teach and tell: eosinophilic granuloma 显示文摘 | Khalil F K Wallis Crespo M C Gilbert Barness E | 2004 | Fetal Pediatr Pathol2004，23，4： | 1 |
| 4 | Inflammation, depressive symptomatology, and coronasry artery disease 显示文摘 | APPELS A BAR F W BAR J | 2000 | Psychosom Med2000，62，5： | 1 |
| 5 | Manganese(Ⅲ)acetate mediated radical reactions in the presence of an ionic liquid显示文摘 | BAR G PARSONS A F THOMAS C B | 2001 | ChemCommun2001，15，： | 1 |
| 6 | Contrasting values of cultural ecosystem services in urban areas:the case of park Montjuc in Barcelona显示文摘 | LANGEMEYER J BARF ROEBELING P | 2015 | Ecosystem Services2015，12，： | 1 |
| 7 | Analysis of angular deformities on radiographs显示文摘 | Bar H F Breitfuss H | 1989 | J Bone Joint Surg Br1989，71，： | 1 |
| 8 | Mitochondrial gene polymorphisms that protect mice from colitis显示文摘 | Bar F Bochmann W Widok A | 2013 | Gastroenterology2013，145，5： | 1 |
| 9 | Comparison of saruplase and al- teplase in acute myocardial infarction 显示文摘 | Bar FW Meyer J Vermeer F | 1997 | Am J Cardiol1997，79，： | 1 |
| 10 | Isolation of γ-glutamyl peptides from comté cheese显示文摘 | Roudot-Algaron F Kerhoas L Le Bars D | | 0，，05： | 1 |
| 11 | Impact of immune escape mutations on HIV-1fitness in the context of the cognate transmitted/founder genome显示文摘 | Song H Pavlicek J W Cai F Bhattacharya T Li H Iyer S S Bar K J Decker J M Goonetilleke N Liu M K Berg A Hora B Drinker M S Eudailey J Pickeral J Moody M A Ferrari G McMichael A Perelson A S Shaw G M Hahn B H Haynes B F Gao F | 2012 | Retrovirology2012，9，： | 1 |
| 12 | Guidelines on the management of valvular heart disease (version 2012) 显示文摘 | Vahanian A Alfieri O Andreotti F Antunes M J Barón-Esquivias G Baumgartner H | 2012 | Eur Heart J2012，33，： | 1 |
| 13 | Comparison of saruplase and alteplase in acute myocardial infarction: SESAM Study Group; the study in Europe with saruplase and alteplase in myocardial infarction显示文摘 | Bar FW Meyer J Vermeer F | 1997 | Am J Cardiol1997，79，： | 1 |
| 14 | Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury显示文摘 | Richard J C Bregeon F Leray V Le Bars D Costes N Tourvieille C | 2007 | Intensive Care Med2007，33，： | 1 |
| 15 | Sim- ple synthesis of 显示文摘 | Le Bars D Malleval M Bonnefoe F | 2006 | J Lable Compd Radiopharm2006，49，： | 1 |
| 16 | DNA height in scanning force microscopy 显示文摘 | Moreno H F Colchero J Bar A M | 2003 | Ultramicroscopy2003，96，： | 1 |
| 17 | Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage orophar',nx carcinoma:comparison of LENT/SOMA, RTOG/ EORTC, and NCI-CTC scoring systems 显示文摘 | Denis F Garaud P Bar let li | 2003 | lnt J Radiat Oncol Biol Phys2003，，： | 1 |
| 18 | Phosphop-eptides from Comet cheese:nature and origin显示文摘 | Le Bars D KerhoasL | 1994 | Journal of Food Science1994，59，： | 1 |
| 19 | Study of' Redhaven' peach and its white-fleshed mutant suggests a key role of CCD4 carote- noid dioxygenase in carotenoid and norisoprenoid volatile metabo- lism显示文摘 | Brandi F Bar E Mourgues F et at | 2011 | BMC Plant Biol2011，，： | 1 |
| 20 | Isolation of ~-Glutamyl Peptides from Comt6 Cheese显示文摘 | Roudot-Algaron F Kerhoas L Le Bars D | 1994 | Journal of Dairy Science1994，，5： | 1 |
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