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| 1 | Schwann cell development,maturation and regeneration:a focus on classic and emerging intracellular signaling pathways显示文摘The development,maturation and regeneration of Schwann cells(SCs),the main glial cells of the peripheral nervous system,require the coordinate and complementary interaction among several factors,signals and intracellular pathways.These regulatory molecules consist of integrins,neuregulins,growth factors,hormones,neurotransmitters,as well as entire intracellular pathways including protein-kinase A,C,Akt,Erk/MAPK,Hippo,mTOR,etc.For instance,Hippo pathway is overall involved in proliferation,apoptosis,regeneration and organ size control,being crucial in cancer proliferation process.In SCs,Hippo is linked to merlin and YAP/TAZ signaling and it seems to respond to mechanic/physical challenges.Recently,among factors regulating SCs,also the signaling intermediates Src tyrosine kinase and focal adhesion kinase(FAK)proved relevant for SC fate,participating in the regulation of adhesion,motility,migration and in vitro myelination.In SCs,the factors Src and FAK are regulated by the neuroactive steroid allopregnanolone,thus corroborating the importance of this steroid in the control of SC maturation.In this review,we illustrate some old and novel signaling pathways modulating SC biology and functions during the different developmental,mature and regenerative | Luca Franco Castelnovo Veronica Bonalume Simona Melfi Marinella Ballabio Deborah Colleoni Valerio Magnaghi | 2017 | Neural Regeneration Research2017，12，7： | 9 |
| 2 | Sixth and seventh tumor-node-metastasis staging system compared in gastric cancer patients显示文摘AIM: To investigate the clinical relevance and prognosis regarding survival according to the changes of the tumor-node-metastasis(TNM) in gastric cancer patients. METHODS: We retrospectively studied 347 consecutive subjects who underwent surgery for gastric adenocarcinoma at the Division of General Surgery, Hospital of Busto Arsizio, Busto Arsizio, Italy between June 1998 and December 2009. Patients who underwent surgery without curative intent, patients with tumors of the gastric stump and patients with tumors involving the esophagus were excluded for survival analysis. Patients were staged according to the 6thand 7thedition TNM criteria; 5-year overall survival rates were investigated, and the event was defined as death from any cause. RESULTS: After exclusion, our study population included 241 resected patients with curative intent for gastric adenocarcinoma. The 5-year overall survival(5-year OS) rate of all the patients was 52.8%. Thediagnosed stage differed in 32% of 241 patients based on the TNM edition used for the diagnosis. The patients in stage Ⅱ according to the 6thedition who were reclassified as stage Ⅲ had significantly worse prognosis than patients classified as stage Ⅱ(5-year OS, 39% vs 71%). According to the 6thedition, 135 patients were classifed as T2, and 75% of these patients migrated to T3 and exhibited a significantly worse prognosis than those who remained T2, regardless of lymph node involvement(37% vs 71%). The new N1 patients exhibited a better prognosis than the previous N1 patients(67% vs 43%). CONCLUSION: 7thTNM allows new T2 and N1 patients to be selected with better prognosis, which leads to different staging. New stratification is important in multimodal therapy. | Tommaso Zurleni Elson Gjoni Andrea Ballabio Roberto Casieri Paola Ceriani Luca Marzoli Francesco Zurleni | 2013 | World Journal of Gastrointestinal Surgery2013，5，11： | 4 |
| 3 | Neutron emission Doppler-shift measurements in deuterium-tritium plasmas 显示文摘 | Frenje J Ballabio L Conroy S | 1999 | Rev Sci Instrum1999，70，1： | 1 |
| 4 | Novel markers of normal and neoplastic human plasmacytoid dendritic cells显示文摘 | Marafioti T Paterson J C Ballabio E | 2008 | Blood2008，111，7： | 1 |
| 5 | Prediction of Italian red wine sensorial descriptors from electronic nose, electronic tongue and spectrophotometric measurements by means of Genetic Algorithm regression models显示文摘 | Buratti S Ballabio D Benedetti S | 2007 | Food Chemistry2007，100，： | 1 |
| 6 | Neutron emission study of DT plasmas heated with tritium neutral beams显示文摘 | Henriksson H Ballabio L Conroy S | 2001 | Rev Sci Instrum2001，72，1： | 1 |
| 7 | Screening for steroid sulfatase(STS) gene deletions by multiplex DNA amplification显示文摘 | Ballabio A Ranier JE Chamberlain JS | 1990 | Hum Genet1990，84，： | 1 |
| 8 | The role of epithelial- mesenchymal transition in cancer pathology显示文摘 | Guarino M Rubino B Ballabio G | 2007 | Patholo- gy2007，39，3： | 1 |
| 9 | Neutron emission spectroscopy at JET - Results from the magnetic proton recoil spectrometer显示文摘 | Ericsson G Ballabio L Conroy S | 2001 | Rev Sci Instrum2001，72，1： | 1 |
| 10 | Monitoring of tlcoholic fermentation using near infrared and mid infrared ;pectroscopes combined with electronic nose and electronic :ongue 显示文摘 | Buratti S Ballabio D Giovanelli G | 2011 | Analytica chirnica acta2011，697，2： | 1 |
| 11 | 查看详情显示文摘 | Baptistella L.H.B Santos J.F.D Ballabio K.C Marsaioli A.J | | 0，，： | 1 |
| 12 | The role of epithelial-mesenchymal transition in cancer pathology 显示文摘 | Guarino M Rubino B Ballabio G | 2007 | Pathology2007，39，3： | 1 |
| 13 | Evaluation of the residual antigenicity of dairy whey hydrolysates obtained by combination of enzymatic hydrolysis and high-pressure treatment 显示文摘 | Penas E Restani P Ballabio C | 2006 | Journal of Food Protection2006，69，7： | 1 |
| 14 | New neutron diagnostics with the magnetic proton recoil spectrometer显示文摘 | K LLNE J BALLABIO L CONROY S | 1999 | Rev Sci Instrum1999，70，1： | 1 |
| 15 | Expression pattern of the ocular albinism type 1 (Oa1) gene in the murine retinal pigment epithelium显示文摘 | Surace EM Angeletti B Ballabio A | 2000 | Invest Ophthalmol Vis Sci2000，41，13： | 1 |
| 16 | MicroRNA expression in multiple myeloma is associated with genetic subtype,isotype and survival显示文摘 | Chi J Ballabio E Chen XH Kusec R Taylor S Hay D | | 0，，： | 1 |
| 17 | Morphine-sparing effect in orthopedic sumerv 显示文摘 | Peduto VA Ballabio M Stefanini S Efficacy of propacetamol in the treatment of postoperative pain | 1998 | Acta Anaesthesiol Scand1998，42，3： | 1 |
| 18 | A new class of biosynthetic anthracyclines: anthracyclinone glucuro- nides显示文摘 | Cassinelli G Ballabio M Grein A | 1987 | JAntibiot(Tokyo)1987，40，7： | 1 |
| 19 | Satins and stroke 显示文摘 | Bersano A Ballabio E Lanfranconi S | 2008 | Current Medical Chemistry2008，15，23： | 1 |
| 20 | A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome 显示文摘 | Carolyn J Brown Andrea Ballabio James L Rupert | 1991 | Nature1991，349，6304： | 1 |
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