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| 1 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 2 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 3 | Institutional factors and market participation by individual farmers:The case of Romania显示文摘 | BALINT B WOBST P | 2006 | Post-Communist Economies2006，18，1： | 1 |
| 4 | Viscous drag reduction using stream wise-aligned riblet 显示文摘 | Vukoslayceic P Wallace J M Balint J L | 1992 | AIAA Journal (S0001-1452)1992，30，4： | 1 |
| 5 | Viscous Drag Reduction Using Stream Wise-Aligned Riblet 显示文摘 | Vukoslayceic P Wallace J M Balint J L | 1992 | AIAA Journal1992，30，4： | 1 |
| 6 | Clinical and ultrasound- based composite disease activity indices in rheumatoid arthritis: Results from a randomized, muhicentre study 显示文摘 | Mandl P Balint P Brault Y | 2012 | Arthritis Care Res2012，65，6： | 1 |
| 7 | Glucose-induced inhibition of in vitro bone mineralization显示文摘 | Balint E Szabo P Marshall CF | 2001 | Bone2001，28，1： | 1 |
| 8 | Clinical and ultra sound-based composite disease activity indices in rheuma told arthritis:results from a multicenter, randomized stud y显示文摘 | Mandl P Balint PV Brault Y | 2013 | Arthritis Care Res (Hoboken)2013，65，87： | 1 |
| 9 | Glucose-induced inhibition of in vitro bone mineralization显示文摘 | Balint E Szabo P Marshall CF | | 0，，01： | 1 |
| 10 | Attention deficit hyperactivitydisorder (ADHD): gender- and age-related differences in neuro- cognition 显示文摘 | Balint S Czobor P Komlosi S | 2009 | Psychol Med2009，39，8： | 1 |
| 11 | Glucose-induced inhibition of in vitro bone mineralization显示文摘 | Szabo P Marshall CF | 2001 | Bone2001，28，1： | 1 |
| 12 | Glucose-induced inhibition of invitro bone mineralization显示文摘 | Balint E Szabo P Marshal F | 2001 | Bone2001，28，1： | 1 |
| 13 | Effects of a low dose estrogen-antiandrogen combination(Diane-35)on clinical signs of and- rogenization, hormone profile and ovarian size in patients with polycystic ovary syndrome显示文摘 | Prelevic G M Wurzburger M I Balint P L | 1989 | Ggnecol Endocrinol1989，13，： | 1 |
| 14 | Glucose - induced inhibi- tion of in vitro bone mineralization显示文摘 | Balint E Szabo P Marshall CF | 2001 | Bone2001，28，1： | 1 |
| 15 | Glucose-induced inhibition of in vitro bone mineralization显示文摘 | Balint E Szabo P Mashall C F | 2001 | Bone2001，28，1： | 1 |
| 16 | Institutional factors and market participa- tion by individual farmers: the case of Romania显示文摘 | BALINT B WOBST P | 2006 | Post-Commu- nist Economies2006，18，1： | 1 |
| 17 | Glucose-induced inhibition of in vitro bone mineralization显示文摘 | Szabo P Marshal CP | 2001 | Bone2001，1，： | 1 |
| 18 | Glucose-induced inhibition of in Vitor bone mineralization显示文摘 | Balint E Szabo P Marshall CF | 2001 | Bone2001，28，1： | 1 |
| 19 | Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells 显示文摘 | Facciabene A Peng X Hagemann I S Balint K Bar- chetti A Wang L P | 2011 | Nature2011，475，： | 1 |
| 20 | Development of a transformation system for Mycosphaerel& pathogens of banana: a tool for the study of host/pathogen interaetions显示文摘 | Balint Kurti P J May G D Churchill A C | 2001 | FEMS Microbiology Letters2001，195，1： | 1 |
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