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| 1 | Colon cancer and the epidermal growth factor receptor:Current treatment paradigms,the importance of diet,and the role of chemoprevention显示文摘Colorectal cancer represents the third most common and the second deadliest type of cancer for both men and women in the United States claiming over 50000 lives in 2014. The 5-year survival rate for patients diagnosed with metastatic colon and rectal cancer is < 15%. Early detection and more effective treatments are urgently needed to reduce morbidity and mortality of patients afflicted with this disease. Here we will review the risk factors and current treatment paradigms for colorectal cancer, with an emphasis on the role of chemoprevention as they relate to epidermal growth factor receptor(EGFR) blockade. We will discuss how various EGFR ligands are upregulated in the presence of Western diets high in saturated and N-6 polyunsaturated fats. We will also outline the various mechanisms of EGFR inhibition that are induced by naturally occurring chemopreventative agents such as ginseng, green tea, and curcumin. Finally, we will discuss the current role of targeted chemotherapy in colon cancer and outline the limitations of our current treatment options, describing mechanisms of resistance and escape. | Baldeep Pabla Marc Bissonnette Vani J Konda | 2015 | World Journal of Clinical Oncology2015，6，5： | 7 |
| 2 | Pathobiological targets of depression显示文摘 | Kanwaljit Chopra Baldeep Kumar Anurag Kuhad | 2011 | Expert Opinion on Therapeutic Targets2011，，4： | 1 |
| 3 | Serum Free Light Chains, An Alternative to the Urine Bence Jones Proteins Screening Test for Monoelonal Gammopathies显示文摘 | Peter G Hill Julia M Forsyth Baldeep Rai | 2006 | Clinical Chemistry2006，52，9： | 1 |
| 4 | Pathobiological targets of depression显示文摘 | Kanwaljit Chopra Baldeep Kumar Anurag Kuhad | 2011 | Expert Opinion on Therapeutic Targets2011，，4： | 1 |
| 5 | Pathobiological targets of depression显示文摘 | Kanwaljit Chopra Baldeep Kumar Anurag Kuhad | 2011 | Expert Opinion on Therapeutic Targets2011，，4： | 1 |
| 6 | Numerical simulation of fluidized dense-phase pneumatic conveying of powders to develop improved model for solids friction factor显示文摘 | Baldeep Kaur Anu Mittal S.S. Mallick Renhu Pan Soumendu Jana | 2017 | Particuology2017，15，6： | 0 |
| 7 | A retrospective cohort study to examine the association between the persistence of abdominal pain after cholecystectomy and ejection fraction on HIDA scan in patients with biliary dyskinesia显示文摘Background and aims:The persistence of pain in patients who underwent cholecystectomy primarily for biliary dyskinesia has been associated with gall bladder ejection fraction(GBEF)found on hepatobiliary iminodiacetic acid(HIDA)scan.Cholecystectomy is a definitive treatment for cholelithiasis but is questionable in biliary dyskinesia.During the postoperative follow-up,gastroenterologists and surgeons often found that some patients with biliary dyskinesia continue to experience biliary pain even after surgery.This study aims to investigate whether the value of GBEF found on the HIDA scan predicts the persistence of pain after cholecystectomy in patients with biliary dyskinesia(EF<35%on HIDA scan).Methods:It is a retrospective cohort study conducted at Kern Medical by recruiting patients from November 2019 to October 2022 in consecutive manner.It is a single sample study consisting of post-cholecystectomy biliary dyskinesia patients with dichotomous outcomes,i.e.,persistent typical recurrent epigastric or right upper quadrant pain with/without meals versus no pain.The primary outcome was the presence of pain 30 days after the cholecystectomy.Univariate analysis was performed with some of the bivariate indicators and continuous predictors,which contained fewer missing elements and had more variation.Results:Univariate logistic regression suggested that HIDA GBEF as a continuous variable does not suggest a relationship with pain after surgery(p=0.3951).A ROC analysis suggested a cutoff of HIDA GBEF=16(AUC=0.60,Specificity=0.5455,Sensitivity=0.7333).Conclusion:Our study does not support the relationship between GBEF found on HIDA scan to improved outcomes after the surgery.But larger controlled trials comparing outcomes of the patients with biliary dyskinesia who did and didn't undergo cholecystectomy are needed to look for other factors. | Baldeep Kaur Mann Janpreet Singh Bhandohal Ishaan Kaha Brian Jean | 2023 | iLIVER2023，2，4： | 0 |
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