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| 1 | Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16" monocyte population via the IL-10/STAT3 axis显示文摘 | Claire Lastrucci Alan Benard Luciana Balboa Karine Pingris Shanti Sourian Renaud Poincloux Talal A Saati Voahangy Rasolofo Pablo Gonzfilez-Montaner Sandra Inwentarz Eduardo Jose Morafia Ivanela Kondova Frank AW Verreck Maria del Carmen Sasiain Olivier Neyrolles Isabelle Maridonneau-Parini Geanncarlo Lugo-Villarino Ce1ine Cougoule | 2015 | Cell Research2015，25，12： | 7 |
| 2 | Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer显示文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients. | Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg Dick Wågsäter | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 3 | Regulation of delayed prostaglandin production in activated P388D1 macrophages by group IV cytosolic and group V secretory phospholipase A2s 显示文摘 | Shinohara H Balboa MA Johnson CA | 1999 | J Biol Chem1999，274，12： | 1 |
| 4 | Comparison of the clinical efficacy and safety of carbamide peroxide and hydrogen peroxide in at-home bleaching gels显示文摘 | Alonso de la Pea V Balboa Cabrita O | 2006 | Quintessence Int2006，37，7： | 1 |
| 5 | Effects ofmidazolam on T-cell immunosuppressive response to surgical stressin mice 显示文摘 | Freire-Garabal M Belmonte A Balboa JL | 1992 | Pharmacol Biochem Behav1992，43，1： | 1 |
| 6 | Amplification mechanisms of inflammation: paracrine stimulation of arachidonic acid mobilization by secreted phospholipase A2 is regulated by cytosolic phospholipase A2 derived hydroperoxyeicosatet- raenoic acid 显示文摘 | Balboa MA Perez R Balsinde J | 2003 | J Immunol2003，171，2： | 1 |
| 7 | The Generic Nature of Pedagogical Content Knowledge among College Professors 显示文摘 | Fernandez Balboa Stidhl | 1995 | Teaching and Teacher Education1995，11，3： | 1 |
| 8 | Transforming growth factor-betal(TGF-betal):a potential recovery signal in the post-ischemie kidney显示文摘 | Docherty N G Perez-Barriocanal F Balboa N E Lopez-Novoa J M | 2002 | Ren Fail2002，24，： | 1 |
| 9 | Nutrient Exports under Different Harvesting Regimes in Fast -growing Forest Plantations in Southern Europe显示文摘 | Merino A Balboa M A Rodriguez Soalleiro R | 2005 | Forest Ecology and Management2005，207，3： | 1 |
| 10 | Mycobacterium tuberculosis impairs dendritic cell response by altering CDlb, DC-SIGN and MR profile显示文摘 | Balboa L Romero MM Yokobori N Schierloh P Geffner L Basile JI Musella RM Abbate E de la Barrera S Sasiain MC Alemdn M | 2010 | Immunol Cell Biol2010，88，7： | 1 |
| 11 | Mycobacterium tubercu- losis impairs dendritic cell response by altering CDlb, DC-SIGN and MR profile显示文摘 | Balboa L Romero MM Yokobori N | 2010 | Immunol Cell Biol2010，88，7： | 1 |
| 12 | Role of Mincle in Alveolar Macrophage-Dependent Innate Immunity against Mycobacterial Infections in Mice显示文摘 | Friederike Behler Kathrin Steinwede Luciana Balboa Bianca Ueberberg Regina Maus Gabriele Kirchhof Sho Yamasaki Tobias Welte Ulrich A. Maus | 2012 | The Journal of Immunology2012，，： | 1 |
| 13 | Weak antiferromagnetism in carboxylato copper(Ⅱ) complexes of bipyridines显示文摘 | Castineiras A Balboa S Bermejo E | 2002 | Z Anorg Allg Chem2002，628，： | 1 |
| 14 | Generalization-oriented Road Line Classification by Means of an Artificial Neural Network显示文摘 | Balboa J L G Francisco J A L | 2008 | GeoInformatica2008，12，3： | 1 |
| 15 | Does a Relationship Exist Between Carotid Stenosis and Lacunar Infarction?显示文摘 | J. Tejada E. Díez-Tejedor L. Hernández-Echebarría O. Balboa | 2003 | Stroke: Journal of the American Heart Association2003，，6： | 1 |
| 16 | Alpha( 1 ) -Antichymotrypsin deficiency associated with liver cirrhosis显示文摘 | Ortega L Balboa F Gonzalez L | 2010 | Pediatr Int2010，52，1： | 1 |
| 17 | A nonprimate animal model to zidovudine pharmacokinetics in humans:inhibition of glucuronidafion and renal excretion of zidovudine by probenecid in rats显示文摘 | Mays DC Dixon KF Balboa A | 1991 | J Pharmacol Exp Ther1991，259，： | 1 |
| 18 | 显示文摘 | D'ANTUONO A DALLO RTO V C BALBOA L | 2001 | J Agric Food Chem2001，49，3： | 1 |
| 19 | A novel functional cell surface dimmer (Kp43) expressed by natural killer cells and T cell receptorgamma/delta+ T lymphocytes 显示文摘 | Balboa M A Ramirez A | 1990 | J Immunol1990，144，： | 1 |
| 20 | Involvement of group ⅥA calcium-independent phospholipase A2 in macrophage engulfment of hydrogen peroxide-treated U937 cells显示文摘 | Perez R Balboa MA Balsinde J | 2006 | J Immunol2006，176，： | 1 |
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