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| 1 | Overlapping expression of microRNAs in human embryonic colon and colorectal cancer显示文摘MicroRNAs (miRNAs ) 为调整房间区别并且维持干细胞的 pluripotent 状态是必要的。尽管特定的 miRNAs 的 dysregulation 与癌症的某些类型被联系了,到日期,没有证据连接了 miRNA 表示在胚胎并且肿瘤纸巾。我们在人的胚胎的结肠组织,并且在 colorectal 癌症估计了成熟 miRNAs 的表示并且配对正常结肠组织。重叠 miRNA 表示在胚胎的结肠的 mucosa 和 colorectal 癌症之间被检测。我们发现了 miR-17-92 聚类,调整在两个盒子中的房间增长并且它的目标, E2F1,在人的冒号开发和结肠的 carcinogenesis 展出表示的一个类似的模式。在 situ,杂交在地窟祖先分隔空间证实了 miR-17-5p 的表示的高水平。我们断定 miRNA 小径在胚胎的开发和结肠的上皮的肿瘤的转变起一个主要作用。 | Mariano Monzo Alfons Navarro Eva Bandres Rosa Artells Isabel Moreno Bemat Gel Rafael Ibeas Jose Moreno Francisco Martinez Tania Diaz Antonio Martinez Olga Balague Jesus Garcia-Foncillas | 2008 | Cell Research2008，18，8： | 32 |
| 2 | MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis显示文摘 | Keun Hur Yuji Toiyama Masanobu Takahashi Francesc Balaguer Takeshi Nagasaka Junichi Koike Hiromichi Hemmi Minoru Koi C Richard Boland Ajay Goel | 2013 | Gut2013，，9： | 6 |
| 3 | Impact of influent characteristics on a partial nitritation SBR treating high nitrogen loaded wastewater显示文摘 | R. Ganigué E.I.P. Volcke S. Puig M.D. Balaguer J. Colprim | 2012 | Bioresource Technology2012，，： | 3 |
| 4 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 5 | Identification of Lynch syndrome: How should we proceed in the 21^(st) century?显示文摘Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appearedin the last few years. | Antoni Castells Francesc Balaguer Sergi Castellví-Bel Victòria Gonzalo Teresa Ocaa | 2007 | World Journal of Gastroenterology2007，13，33： | 3 |
| 6 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 7 | OVERVIEW OF COMPLEX SYSTEMS IN SPORT显示文摘The complex systems approach offers an opportunity to replace the extant pre-dominant mechanistic view on sport-related phenomena.The emphasis on the environment-system relationship,the applications of complexity principles,and the use of nonlinear dynamics mathematical tools propose a deep change in sport science.Coordination dynamics,ecological dynamics,and network approaches have been successfully applied to the study of different sport-related behaviors,from movement patterns that emerge at different scales constrained by specific sport contexts to game dynamics.Sport benefit from the use of such approaches in the understanding of technical,tactical,or physical conditioning aspects which change their meaning and dilute their frontiers.The creation of new learning and training strategies for teams and individual athletes is a main practical consequence.Some challenges for the future are investigating the influence of key control parameters in the nonlinear behavior of athlete-environment systems and the possible relatedness of the dynamics and constraints acting at different spatio-temporal scales in team sports.Modelling sport-related phenomena can make useful contributions to a better understanding of complex systems and vice-versa. | BALAGUE Natàlia TORRENTS Carlota HRISTOVSKI Robert DAVIDS Keith ARAUJO Duarte | 2013 | Journal of Systems Science & Complexity2013，26，1： | 2 |
| 8 | Achievement goals in sport:The development and the validation of the Perception of Success Questionnaire显示文摘 | Treasure D C Balague G | 1998 | Journal of Sports Sciences1998，16，： | 1 |
| 9 | HLM1,an essential signaling component in the hypersensitive response,is a member of the cyclic nucleotide-gated channel ion channel family显示文摘 | Balagué C Lin B Alcon C | 2003 | The Plant Cell2003，15，2： | 1 |
| 10 | Acute phase is the only significantly reduced component of the injury response after laparoscopic cholecystectomy显示文摘 | Targarona EM Pons MJ Balague C | 1996 | World J Surg1996，20，5： | 1 |
| 11 | Routine intraope rative completion angiography after coronary artery bypass grafting and 1-stop hybrid revascularization results from a fully integrated hybrid catheterization laboratory/operating room显示文摘 | Zhao DX Leacche M Balaguer JM | 2009 | J Am Coll Cardiol2009，53，3： | 1 |
| 12 | Environmental xenoestrogens, antiandrogens and disorders of male sexual differentiation显示文摘 | Sultan C Balaguer P Terouanne B | 2001 | Mol Cell Endocrinol2001，178，12： | 1 |
| 13 | 显示文摘 | Martin M J Artola A Balaguer M D | 2003 | Chemical Engrgneering Journal?2003，94，3： | 1 |
| 14 | Lesion mimic mutants:keys for deciphering cell death and defense pathways in plants?显示文摘 | Lormin s Vailleau F Balague C | 2003 | Trends Plant Sci2003，8，6： | 1 |
| 15 | Partial ammonium oxidation to nitrite of high ammonium content urban landfill leachates 显示文摘 | R Ganigue H Lopez M D Balaguer | 2007 | Water Research2007，41，15： | 1 |
| 16 | Tourism as a Long-run Economic Growth Factor:The Spanish Case显示文摘 | Balaguer J Cantavalla-JordaM | 2002 | Applied Economics2002，，3： | 1 |
| 17 | Tourism as a Long-run Economic Growth Factor: The Spanish Case显示文摘 | Balaguer L Cantavella-Jorda M | 2002 | Applied Economics2002，，34： | 1 |
| 18 | Non-specific low back pain显示文摘 | Balagué F Mannion AF Pellisé F | 2012 | Lancet2012，379，9814： | 1 |
| 19 | Mesh in the hiatus: a controversial issue显示文摘 | Targarona EM Bendahan G Balague C | 2004 | Arch Surg2004，139，12： | 1 |
| 20 | Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane显示文摘 | te Welscher YM ten Napel HH Balague MM Souza CM Rieaman H de Kruijff B et ol | 2008 | J Biol Chem2008，283，10： | 1 |
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