|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | 有为腹的 CT 的非线性的适应过滤器的申请的放射剂量减小显示文摘 AIM:To evaluate the effect of non-linear adaptive filters (NLAF) on abdominal computed tomography (CT) images acquired at different radiation dose levels.METHODS:Nineteen patients (mean age 61.6 ± 7.9 years,M:F=8:11) gave informed consent for an Institutional Review Board approved prospective study involving acquisition of 4 additional image series (200,150,100,50 mAs and 120 kVp) on a 64 slice multidetector row CT scanner over an identical 10 cm length in the abdomen.The CT images acquired at 150,100 and 50 mAs were processed with the NLAF.Two radiologists reviewed unprocessed and processed images for image quality in a blinded randomized manner.CT dose index volume,dose length product,patient weight,transverse diameters,objective noise and CT numbers wererecorded.Data were analyzed using Analysis of Variance and Wilcoxon signed rank test.RESULTS:Of the 31 lesions detected in abdominal CT images,28 lesions were less than 1 cm in size.Subjective image noise was graded as unacceptable in unprocessed images at 50 and 100 mAs,and in NLAF processed images at 50 mAs only.In NLAF processed images,objective image noise was decreased by 21% (14.4 ± 4/18.2 ± 4.9) at 150 mAs,28.3% (15.7 ± 5.6/21.9 ± 4) at 100 mAs and by 39.4% (18.8 ± 9/30.4 ± 9.2) at 50 mAs compared to unprocessed images acquired at respective radiation dose levels.At 100 mAs the visibility of smaller structures improved from suboptimal in unprocessed images to excellent in NLAF processed images,whereas diagnostic confidence was respectively improved from probably confident to fully confident.CONCLUSION:NLAF lowers image noise,improves the visibility of small structures and maintains lesion conspicuity at down to 100 mAs for abdominal CT. | Sarabjeet Singh Mannudeep K Kalra Mi Kim Sung Anni Back Michael A Blake | 2012 | World Journal of Radiology2012，4，1： | 3 |
| 3 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 4 | BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia显示文摘 | Han BH DCosta A Back SA | 2000 | Neurobiol Dis2000，7，1： | 1 |
| 5 | Density-functional thermochemistry Ⅲ: The role of exact exchange显示文摘 | Backe A D | 1993 | J Chem Phys1993，98，7： | 1 |
| 6 | Cellular markers of systemic inflammation and immune suppression in patients with organ failure due to severe acute pancreatitis 显示文摘 | Kylanpaa A Back ML Takala A | 2001 | Scand J Gastroenterol2001，36，10： | 1 |
| 7 | BDNF blocks easpase-3 acti-ration in neonatal hypoxia ischemia显示文摘 | Han BH D Costa A Back SA | 2000 | Neurobiol Dis2000，7，1： | 1 |
| 8 | Maturation-dependent vulnerability of perinatal white matter in premature birth 显示文摘 | Back S A Riddle A McClure M M | 2007 | Stroke2007，38，2： | 1 |
| 9 | 显示文摘 | Backes W H Bobbers P A Vanhaeringen W | 1994 | Phys Rev B1994，49，： | 1 |
| 10 | The bHLH transcription factor Tci21 is required for lineage-specific EMT of cardiac fibroblast pro- genitors 显示文摘 | Aeharya A Back ST Huang G | 2012 | Development2012，139，12： | 1 |
| 11 | Maturation-dependent vulnerability of perinatal white matter in premature birth显示文摘 | Back SA Riddle A McClure MM | | 0，，： | 1 |
| 12 | Blended learn- ing approach improves teaching in a problem - based learning environment in orthopedics - a pilot study显示文摘 | Back D A Haberstroh N Antolic A | 2014 | Bmc Medical Education2014，14，1： | 1 |
| 13 | Maturation-dependent vulnerability of perinatal white matter in premature birth显示文摘 | Back SA Riddle A MeClure MM | 2007 | Stroke2007，38，2： | 1 |
| 14 | Retrospective analysis of unstaged and staged Gamma Knife surgery with and without preceding embolization for the treatment of arteriovenous malformations显示文摘 | Back A G Vollmer D Zeck O | 2008 | J Neurosurg2008，12，109： | 1 |
| 15 | BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia显示文摘 | Han BH D' Costa A Back SA | 2000 | Neurobiol Dis2000，7，1： | 1 |
| 16 | Comparative study of wear-resistant DLC and fullerene- like CNx coatings produced by pulsed laser and filtered cathodic arc depositions 显示文摘 | Voevodin A Jones J Back T | 2005 | Surface Coatings Technology2005，197，1： | 1 |
| 17 | Laser-plasma interactions in ignition-scale hohlraum plasmas显示文摘 | MacGOWAN B J AFEYAN B B BACK C A | 1996 | Physics of Plasmas1996，3，5： | 1 |
| 18 | Role of decompressive hemicraniectomy in extensive middle cerebral artery strokes: a meta-analysis of randomised trials 显示文摘 | Back L Nagaraja V Kapur A | 2015 | Intern Med J2015，45，7： | 1 |
| 19 | Matnration-dependent vulnerability of perinatal white matter in premature birth 显示文摘 | Back SA Riddle A McClure MM | 2007 | Stroke2007，38，2： | 1 |
| 20 | Detailed measurements of a diffusive supersonic wave in a radiatively heated foam显示文摘 | Back C A Bauer J D Landen O L | 2000 | Phys Rev Lett2000，84，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员