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| 1 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 2 | A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction显示文摘早熟的出生的率是惊人的并且威胁社会和世界范围的保健系统。早产在超过 50% 盒子导致早熟的出生。Preterm 出生说明婴儿病态和死亡的 three-quarters。在 34 星期怀孕期前熬过出生的孩子经常面对终生的残疾。为劳动正在想要的 preterm 的当前的处理。没有处理被发现了通常有效,任何一个都系统地没在 48 h 以外被评估。preterm 劳动的处理的新途径绝望地被需要。从我们的实验室的最近的研究建议子宫的肌肉是有不同于另外的光滑的肌肉的子宫的松驰的规定的唯一的分隔空间。这里,我们讨论最近的证据机械地激活的 2 毛孔钾隧道, TREK-1,可以贡献在子宫的光滑的肌肉和变体与人的劳动联系了的那 TREK-1 基因发信号的收缩松驰, preterm 劳动可以导致 preterm 劳动和它的可能的预防的更好的理解。 | Iain L O BUXTON Nathanael HEYMAN Yi-ying WU Scott BARNETT Craig ULRICH | 2011 | Acta Pharmacologica Sinica2011，32，6： | 2 |
| 3 | Histone deacetylase activities are required for innate immune cell control of Thl but not Th2 effector cell function显示文摘 | Brogdon J L Xu Y Szabo S J An S Buxton F Cohen D | 2007 | Blood2007，109，： | 1 |
| 4 | Stimulation of c Jun kinase and mitogen-activated protein kinase by isehemia and reperfusion in the perfused rat heart 显示文摘 | KNIGHT R J BUXTON D B | 1996 | Biochemical and Biophysical Research Communications1996，218，： | 1 |
| 5 | Cloning and molecular analysis of the ornithine carbamoyl transferase gene of Aspergillus niger显示文摘 | BUXTON FP GWYNNE DI GARVEN S | 1987 | Gene1987，60，： | 1 |
| 6 | Intranasal immunization with Toxoplasma gondii tachyzoite antigen encapsulated into PLG microspheres induces humoral and cell mediated immunity in sheep 显示文摘 | Stanley AC Buxton D Innes EA | 2004 | Vaccine2004，22，2930： | 1 |
| 7 | Frequent expression of CD99 in anaplastic large cell lymphoma: a clinicopathologic and immtmohistochemical study of 160 cases 显示文摘 | Buxton D Bacchi CE Gualco G | 2009 | Am J Clin Pathol2009，131，4： | 1 |
| 8 | Critical review of rate constants for reactions of hydrated electrons, hydrogen atom and hydroxyl radicals (OH/O) in aqueous solution 显示文摘 | Buxton G V Ereenstock C L Helman W P | 1988 | Journal of Physical and Chemical Reference Data1988，17，2： | 1 |
| 9 | Association be-tween injection practices and duration of injection among re-cently initiated injection drug users显示文摘 | Becker Buxton M Vlahov D Strathdee SA | 2004 | Drug Alcohol Depend2004，75，2： | 1 |
| 10 | Critical review of rate constants for reactions of hydrated electrons,hydrogen atoms and hydroxyl radicals in aqueous solution显示文摘 | Buxton G V Greenstock C L Helman W P | 1988 | Journal of Physical and Chemical Reference Data1988，，17： | 1 |
| 11 | Neuroendoscopic third ventriculostomy for hydrocephalus in adults: report of a single unit's experience with 63 cases 显示文摘 | Buxton N Ho KJ Macarthur D | 2001 | surg Neurol2001，55，2： | 1 |
| 12 | Evaluating patient - based outcome measures for use in clinical trials 显示文摘 | Fitzpatrick R Davey C Buxton MJ | 1998 | Health Technol Assess1998，2，14： | 1 |
| 13 | A general kinetic model for quantitative perfusion imaging woth arterial spin labeling 显示文摘 | Buxton R B Frank L P Wong E C et aI | 1998 | Magn Reson Med1998，40，3： | 1 |
| 14 | MePhersonⅢ,osteoadaorptive Bisphosphonate derivatives of fluoroquinolone antibacterials显示文摘 | Herezeg Thomas B Buxton James C | 2002 | J Med Chem2002，45，： | 1 |
| 15 | Ultrasonic endoscope显示文摘 | DiMagno E P Buxton J L Regan P T Hattery R R Wilson D A Suarez J R | 1980 | Lancet1980，1，： | 1 |
| 16 | A methodology for environmental impact minimization:solvent design and reaction path synthesis issues显示文摘 | Stefanis S K Buxton A Livingston A G Pistikopoulos E N | 1996 | Computers & Chemical Engineering1996，20，： | 1 |
| 17 | Implementation of quantittative perfusion imaging techniques for function brin mapping using pulsed arterial spin labeling显示文摘 | Wong E C Buxton R B Frank L P | 1997 | NMR Biomed1997，10，45： | 1 |
| 18 | Consultation with health care professionals and influenza immunization among women in contact with young children 显示文摘 | Chambers CT Buxton JA Koehoom M | 2010 | Can J Public Health2010，101，1： | 1 |
| 19 | Plant limitations to fiber digestion and utilization显示文摘 | Buxton D R Redfearn D D | 1997 | Journal of Nutrition1997，127，： | 1 |
| 20 | Protozoan infections (Toxoplasma gondii,Neospora caninum and Sarcocystis SPP) in sheep and goats显示文摘 | Buxton D | 1998 | Vet Res1998，29，： | 1 |
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