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| 1 | Adenoma and advanced neoplasia detection rates increase from 45 years of age显示文摘BACKGROUND Colonoscopy is considered a valid primary screening tool for colorectal cancer(CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate(ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years.AIM To compare the ADR and advanced neoplasia detection rate(ANDR) according to age in a large series of patients during routine colonoscopy.METHODS All consecutive patients who were scheduled for colonoscopy were included.Exclusion criteria were as follows: patients scheduled for partial colonoscopy or interventional colonoscopy(for stent insertion or stenosis dilation).Colonoscopies were performed in our unit by a team of 30 gastroenterologists in2016. We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC(excluding patients with personal or family history of advanced adenoma or cancer).RESULTS6027 colonoscopies were performed in patients with a median age of 57 years(range, 15-96). The ADR and ANDR were 28.6% and 9.7%, respectively, in the whole population. When comparing patients aged 40-44(n = 382) and 45-49 years (n = 515), a strong increase in all parameters from 45 years was observed, with the ADR rising from 9.7% in patients aged 40-44 to 21.2% between 45 and 49(P <0.001) and the ANDR increasing from 3.1% in patients aged 40-44 to 6.4% in those aged 45-49 years(P < 0.03). With regard to patients aged 50-54(n = 849), a statistically significant increase in the ADR and ANDR was not observed between patients aged 45-49 and those aged 50-54 years. In the population with an average risk of CRC, the ADR and ANDR were still significantly higher in patients aged 45-49 compared with those aged 40-44 years.CONCLUSION This study shows a significant two-fold increase in the ADR and ANDR in patients aged 45 years and over. | David Karsenti Gaelle Tharsis Pascal Burtin Franck Venezia Gilles Tordjman Agnès Gillet Joelle Samama Karine Nahon-Uzan Philippe Cattan Maryan Cavicchi | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 2 | Dynamic analysis of a variable displacement pump显示文摘 | Schoenau G J Burtin R T Kavanagh G P | 1990 | Trans of the ASME1990，112，： | 2 |
| 3 | Adjuvant chemotherapy with 5-fluorouracil and cisplatin compared with surgery alone for gastric cancer:7-year results of the FFCD randomized phase Ⅲ trial (8801)显示文摘 | Bouche O Ychou M Burtin P | 2005 | Ann Oncol2005，16，9： | 1 |
| 4 | The importance of components of pulmonary rehabilitation, other than exercise training, in COPD显示文摘 | Hill K Vogiatzis I Burtin C | 2013 | Eur Respir Rev2013，22，129： | 1 |
| 5 | Sodium restriction decreases AP-1 activation after nephron reduction in the rat: role in the progression of renal lesions显示文摘 | Terzi F Burtin M Hekmati M | 2000 | Exp Nephrol2000，8，2： | 1 |
| 6 | Influence of surface area and additives on the thermal stability of transition alumina catalyst supports:I:kinetic data显示文摘 | BURTIN P BRUNELLE J P PIJOLAT M | | 0，，： | 1 |
| 7 | Abnormalities of the ocular surface in patients with AIDS显示文摘 | Burtin T Guepratte N Bourges JL Garcher C Le Hoang P Bau- douln C | 1998 | J Fr Ophtalmol1998，21，9： | 1 |
| 8 | The usefulness of ultrasonic microprobe imaging for endoscopic variceal ligation显示文摘 | Burtin P Cales P Oberti F | | 0，，03： | 1 |
| 9 | Synthesis and biologlcal evaluatlon of novel pyrazoles and inclazoles as activators of the nitric oxide receptor, soluble guanylate cyclase 显示文摘 | $elwood D L Brummell D G Burtin G E | 2001 | J Med Chem2001，，44： | 1 |
| 10 | Targerted expression of a dominant - negative EGF - R in the kidney reduces tubulo - interstitial lesions af- ter renal injury显示文摘 | Terzi F Burtin M Hekraati M | 2006 | J Clin Invest2006，106，2： | 1 |
| 11 | Cystic gene dosage influences kidney lesions after nephron reduction显示文摘 | Le Corre S Viau A Burtin M | 2015 | Nephron2015，129，1： | 1 |
| 12 | Adjuvant chemother apy with 5-fluorouracil and cisplatin compared with sur- gery alone for gastric cancer: 7-year results of the FFCD randomized phase III trial(8 801) 显示文摘 | Bouche O Ychou M Burtin P | 2005 | Ann Oncol2005，16，9： | 1 |
| 13 | Early exercise in critically ill patients enhances short - term functional recovery 显示文摘 | Burtin C Clerckx B Robbeets C | 2009 | Crit Care Med2009，37，9： | 1 |
| 14 | Pharrna- cokinetics of midazolam during continuous infusion in critically ill neonates显示文摘 | Jacqz-Aigrain E Daoud P Burtin P | 1992 | Eur J Clin Pharmacol1992，42，3： | 1 |
| 15 | Endoscopic detection of early esophageal cancer in high-risk population : does Lugol staining improve videoendoscopy 显示文摘 | MEYER V BURTIN P BOILRB | 1997 | Gastrointest Endosc1997，45，： | 1 |
| 16 | Abdominoperineal resection for locally recurrent rectal cancer 显示文摘 | Bergamasehi R Pessaux P Burtin P | 2001 | Tech Coloproctol2001，5，2： | 1 |
| 17 | Dynamic Analysis of a Variable Displacement Pump显示文摘 | SCHOENAU G J BURTIN R T KAVANAGH G P | 1990 | Transations of the ASME1990，112，： | 1 |
| 18 | Modification of hybrid walnut wood color and phenol composition under various steaming conditions 显示文摘 | Burtin P | 2000 | Holzforschung2000，，54： | 1 |
| 19 | Endoscopic ultrasonographic signs of portal hypertension in cirrhosis显示文摘 | Burtin P calesp F berti F | 1996 | Gastromtest Endose1996，44，： | 1 |
| 20 | Early exercise in critically ill patients enhances short-term tunctional recovery 显示文摘 | Burtin C Clerckx B Robbeets C | 2009 | Crit Care Med2009，37，9： | 1 |
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