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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Vasopeptidase inhibitors: a new therapeutic concept in cardiovascular disease? 显示文摘 | BURNETT J C Jr RORLEAU J L | 2001 | Circulation2001，104，15： | 1 |
| 3 | Fundulus as the premier teleost model in environmental biology: Opportunities for new insights using genomics显示文摘 | BURNETT K Q BAIN L J BALDWIN W S | 2007 | Comparative Biochemistry and Physiology Part D: Genomics Proteomics2007，2，4： | 1 |
| 4 | Investigation on wind power potential on Hong Kong islands-an analysis of wind power and wind turbine characteristics显示文摘 | Lu L Yang H X Burnett J | 2002 | Renewable Energy2002，27，1： | 1 |
| 5 | Toxinological studies on the nematocyst venom of Chrysaora achlyos 显示文摘 | Radwan F F Y Gershwin L Burnett J W | 2000 | Toxieon2000，38，： | 1 |
| 6 | Reactive oxygen intermediate production by oyster hemocytes exposed to hypoxia显示文摘 | Boyd J N Burnett L E | 1999 | The Journal of Experimental Biology1999，202，： | 1 |
| 7 | A prospective randomized clinical trial of patellar resurfa cing and nonresurfacing in bilateral TKA显示文摘 | Burnett R S Boone J L McCarthy K P Rosenzweig S Barrack R L | 2007 | Clin Orthop Relat Res2007，，： | 1 |
| 8 | Assessing the cost effectiveness of an environmental assessment scheme显示文摘 | Chau C K Burnett J Lee W L | 2000 | Building and Environment2000，35，4： | 1 |
| 9 | Immune defense reduces respiratory fitness inCallinectessapidus,the Atlantic blue crab显示文摘 | Burnett L E Holman J D Jorgensen D D | 2006 | Biological Bulletin2006，211，1： | 1 |
| 10 | Speech articulator measurements using low power EM-wave sensors显示文摘 | Holzrichter J F Burnett G C Ng L C | 1998 | Journal of the Acoustical Society of America1998，103，1： | 1 |
| 11 | Genetic determinants of hepatic steatosis in man显示文摘 | HOOPER A J ADAMS L A BURNETT J R | 2011 | J Lipid Res2011，52，4： | 1 |
| 12 | Quantification of dust removal and ozone emission of ionizer air-cleaners bychamber testing显示文摘 | Niu J L Tung T C W J Burnett | | 0，，： | 1 |
| 13 | Guideline for the management of clinically localized prostate cancer: 2007 update显示文摘 | Thompson I Thrasher J B Aus G Burnett A L Canby-Hagino E D Cookson M S | 2007 | J Urol2007，177，： | 1 |
| 14 | Intrinsic birefringence in calcium fluoride and barium fluoride显示文摘 | Burnett J H Zachary H L Eric L | 2001 | Shirley Physical Review B2001，64，24： | 1 |
| 15 | Atrial and pulmonary endothelin mRNA is increased in a canine model of chronic low cardiac output 显示文摘 | Wei C M Clavell A L Burnett J C | 1997 | Am J Physiol Regulatory Integrative Comp Physiol1997，273，2： | 1 |
| 16 | Hapatopulmonary syndrome: a prospective study of relationships between severity of liver disease,PaO2 response to 100% Oxygen, and brain uptake after 99mTc MAA lung scanning 显示文摘 | Rrowa M J Wiseman G A Burnett O L | 2000 | Chest2000，118，： | 1 |
| 17 | Natriuretic peptides in the diagnosis and management of chronic heart failure显示文摘 | BOERRIGTER G COSTELLO-BOERRIGTER L C BURNETT JR J C | 2009 | Heart Fail Clin2009，5，： | 1 |
| 18 | Diffusion of large two-dimensional Ag clusters on Ag(100) 显示文摘 | CHANG S L BURNETT J W | 1994 | Phys Rev Lett1994，73，： | 1 |
| 19 | Herpes simplex virus (HSV)-associated erythema muhiforme (HAEM): A viral disease with an autoimmune component显示文摘 | Aurelian L Ono F Burnett J | 2003 | Dermatol Online J2003，9，1： | 1 |
| 20 | Cytochrome P450 2El is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes 显示文摘 | Zangar R C Benson J M Burnett V L | 2000 | Chemico-Biological Interactions2000，125，3： | 1 |
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