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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Association between ozone and hospitalization for respiratory diseases in 16Canadian cities显示文摘 | Burnett R T Brook J R Yung W T | 1997 | Environmental Research1997，72，： | 1 |
| 3 | Large- scale survey of thermal comfort in office premises in Hong Kong 显示文摘 | Chan D W T Burnett J de Dear R J etal | 1998 | ASHRAE Transactions1998，104，1： | 1 |
| 4 | A methodology to investigate the particulate penetration coefficient through building shell 显示文摘 | TUNG C W ( HA() C Y H BURNETT J | 1999 | Atmospheric Environment1999，33，： | 1 |
| 5 | Vitamin E in human health and disease显示文摘 | Clarke M W Burnett J R Croft K D | 2008 | Critical Reviews in Clinical Laboratory Sciences2008，45，5： | 1 |
| 6 | Fundulus as the premier teleost model in environmental biology: Opportunities for new insights using genomics显示文摘 | BURNETT K Q BAIN L J BALDWIN W S | 2007 | Comparative Biochemistry and Physiology Part D: Genomics Proteomics2007，2，4： | 1 |
| 7 | Field evaluation of seepage meters in the coastal marine environment 显示文摘 | CABLE J E BURNETT W C CHANTON J P | 1997 | Estuarine Coastal and Shelf Science1997，45，3： | 1 |
| 8 | Toxinological studies on the nematocyst venom of Chrysaora achlyos 显示文摘 | Radwan F F Y Gershwin L Burnett J W | 2000 | Toxieon2000，38，： | 1 |
| 9 | Changes in some physical characteristics of the digesta in the reticulo-rumen of cows fed once daily显示文摘 | EVANS E W PEARCE G R BURNETT J | 1973 | British Journal of Nutrition1973，29，3： | 1 |
| 10 | 查看详情显示文摘 | J A Dunningham K Burnett R Roth W D Phillips | | 0，，09： | 1 |
| 11 | Measurement and significance of the direct discharge of groundwater into the coastal zone显示文摘 | BURNETT W C TANIGUCHI M OBERDORFER J | 2001 | Sea Research2001，46，2： | 1 |
| 12 | Measurement and significance of the direct dischmge of groundwater into the coastal zone 显示文摘 | Burnett W C Taniguchi M Oberdorfer J | 2001 | J Sea Res2001，46，2： | 1 |
| 13 | A methodology to investigate the particulate penetration coefficient through building shell显示文摘 | TUNG T C W CHAO C Y H BURNETT J | 1999 | Atmospheric Environment1999，33，6： | 1 |
| 14 | Assessing the cost effectiveness of an environmental assessment scheme显示文摘 | Chau C K Burnett J Lee W L | 2000 | Building and Environment2000，35，4： | 1 |
| 15 | FieldEvaluation of Seepage Meters in the Coastal MarineEnvironment 显示文摘 | CABLE J E BURNETT W C CHANTON J P | 1997 | Estuarine Coastal and Shelf Science1997，45，3： | 1 |
| 16 | Estimating groundwater discharge into the northeastern Gulf of Mexico using Radon-222显示文摘 | CABLE J E BURNETT W C CHANTON J P | 1996 | Eaflh and Planetary Science Letters1996，144，： | 1 |
| 17 | Quantification of dust removal and ozone emission of ionizer air-cleaners bychamber testing显示文摘 | Niu J L Tung T C W J Burnett | | 0，，： | 1 |
| 18 | A methodology to investigate the particulate penetration coefficient through building shell 显示文摘 | Tung T C W Chao C Y H Burnett J | 1999 | Atmospheric Environment1999，33，： | 1 |
| 19 | Carbon dioxide emissions and economic growth in the US显示文摘 | Burnett J W Bergstrom J C Wetzstein M E | 2013 | Journal of Policy Modeling2013，35，6： | 1 |
| 20 | Molecular product ormation from the charge-transfer state of C6H6I 显示文摘 | DEBOER G BURNETT J W YOUNG M A | 1996 | Chem Phys Lett1996，259，： | 1 |
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