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| 1 | 分子修饰的重组百日咳毒素S1亚单位的生物学和免疫学特性显示文摘目的:对重组杆状病毒表达的经多种信号序列修饰的天然和变异百日咳毒素(PT)S1亚单位(rS1)的生物学及免疫学特性作出评价。方法:应用生物化学和免疫学技术与方法对这些rS1的酶活性、分泌性和免疫原性等做了系统鉴定。结果:rS1变异子无可检出的酶活性;所有rS1均不能由细胞分泌,可从细胞膜组分中大量检出,但不能从可溶性胞浆蛋白组分或细胞培养上清中检出;rS1分子内部含有3个疏水性区域;rS1虽不能与B寡聚体结合形成PT全毒素,但均能诱导抗PT免疫应答。结论:这些rS1极可能以膜蛋白形式存在,其非分泌性与分子内部的疏水性区域有关;所有rS1均保持其免疫原性。 | 于康震 Burnette W N Kaslow H R Yilma T D | 1999 | 中国免疫学杂志1999，15，4： | 4 |
| 2 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 3 | The potential role of resistin in atherogenesis 显示文摘 | BURNETT M S LEE C W KINNAIRD T D | 2005 | Atherosclerosis2005，182，： | 1 |
| 4 | Association between particulate and gas-phase components of urban air pollution and daily mortality in eight Canadian cities显示文摘 | Burnett RT Brook J Dann T | | Inhal Toxicol0，12，： | 1 |
| 5 | Lung cancer,cardiopulmonary mortality and long-term exposure to fineparticulate air pollution显示文摘 | Pope C A Burnett R T Thun M J | 2002 | Journal of the American MedicalAssociation2002，287，9： | 1 |
| 6 | Prepulses reduce the pain of cutaneous electrical shocks 显示文摘 | BLUMENTHAL T D BURNETT T T SWERDLOW C D | 2001 | Psychosom Med2001，63，2： | 1 |
| 7 | Local delivery of marrow- derived stromal ceils augments collateral perfusion through paracrine mechanisms 显示文摘 | Kinnaird T Stabile E Burnett MS | 2004 | Circulation2004，109，： | 1 |
| 8 | Association between particulate-and gas-phase components of urban air pollution and daily mortality in eight Canadian cities显示文摘 | BURNETT R T BROOK J DANN T | 2000 | Inhal Toxicol2000，12，4： | 1 |
| 9 | Bone - marrow - derived cells for enhancing collateral development:mecha- nisms, animal data, and initial clinical experiences 显示文摘 | Kinnaird T Stabile E Burnett MS | 2004 | Cire Res2004，95，4： | 1 |
| 10 | Cardiovascular mortality and long term exposure to particulateair pollution: epidemicolo- gical evidence of general pathophysiological path ays of disease显示文摘 | POPE C A BURNETT R T THURSTON G D | 2004 | Circ- ulation2004，109，： | 1 |
| 11 | Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms显示文摘 | Kinnaird T Stabile E Burnett MS | 2004 | Circ Res2004，94，5： | 1 |
| 12 | Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic eytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms显示文摘 | Kinnaird T Stabile E Burnett MS | 2004 | Circ Res2004，94，： | 1 |
| 13 | Matrix metalloproteinases : pathways of induction by bio- active molecules显示文摘 | Tsuruda T Costello - Boerrigter LC Burnett JC Jr | 2004 | Heart Fail Rev2004，9，1： | 1 |
| 14 | Local delivery of warrowderived stromal cells augments collateral perfusion through paracrine mechanisms显示文摘 | Kinnaird T Stabile E Burnett MS | 2004 | Circulation2004，109，12： | 1 |
| 15 | Changing the surface mechanical properties of sillicon and α-Al2 O3 by ion implantation显示文摘 | Burnett P J Page T F | 1984 | Mater Sci1984，19，11： | 1 |
| 16 | Marrow-derivedstromal cells express genes encoding :/broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms显示文摘 | Kirmaird T Stabile E Burnett MS | 2004 | Circ Res2004，94，5： | 1 |
| 17 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 18 | Extremely high multiplicities in high-energy nucleus-nucleus collisions显示文摘 | Burnett T H Dake S Fuki M | 1983 | Phys Rev Lett1983，50，26： | 1 |
| 19 | Association between ozone and hospitalization for respiratory diseases in 16Canadian cities显示文摘 | Burnett R T Brook J R Yung W T | 1997 | Environmental Research1997，72，： | 1 |
| 20 | Small worlds, lifeworlds, and information: The ramifications of the information behaviour of social groups in public policy and the public sphere 显示文摘 | Burnett G Jaeger P T | | Information Research0，13，2： | 1 |
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