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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | The Mechanical Properties of Wear-resistant Coatings:I Modelling of Hardness Havior显示文摘 | Rickerby D S | 1987 | Thin Solid Film s1987，148，： | 1 |
| 3 | IFCC recommendationon reporting results for blood glucose显示文摘 | Burnett RW D'0razio P Fogh-Andersen al | 2001 | Clin Chim Acta2001，307，12： | 1 |
| 4 | The relationship between hardness and scratch adhesion显示文摘 | Burnett P J Rickerby D S | 1987 | Thin Solid Films1987，154，： | 1 |
| 5 | Quantifying submarine groundwater discharge in the coastal zone via multiple methods显示文摘 | BURNETT W C AGGARWAL P K AURELI A | 2006 | Science of the Total Environment2006，367，23： | 1 |
| 6 | IFCC reeonmmn- dation on reporting results for blood giucose显示文摘 | Burnett RW Dorazio P Fogh-Andersen N | 2001 | Clin Chim2001，307，12： | 1 |
| 7 | Partial purification of box jellyfish (Chironex fleckeri) nematocyst venom isolated at the beachside显示文摘 | Bloom DA Burnett JW Alderslade P | 1998 | Toxicon1998，36，8： | 1 |
| 8 | A personality trait inter- nationalists model of job performance 显示文摘 | Tett R P Burnett D | 2003 | Journal of APsychology2003，88，： | 1 |
| 9 | Activities,context and ubiquitous computing显示文摘 | Prekop P Burnett M | 2003 | Computer Communications2003，26，： | 1 |
| 10 | Changing the surface mechanical properties of sillicon and α-Al2 O3 by ion implantation显示文摘 | Burnett P J Page T F | 1984 | Mater Sci1984，19，11： | 1 |
| 11 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 12 | The emerging role of targeted therapy for hematologic maligncies: update on bortezomib and tipifarnib 显示文摘 | ARMAND J P BURNETT A K DRACH J | 2007 | Oncologist2007，12，： | 1 |
| 13 | Small worlds, lifeworlds, and information: The ramifications of the information behaviour of social groups in public policy and the public sphere 显示文摘 | Burnett G Jaeger P T | | Information Research0，13，2： | 1 |
| 14 | 查看详情显示文摘 | Fan W H Burnett A Upadhya P C | | 0，，： | 1 |
| 15 | The relationship between hardness and scratch adhession显示文摘 | BURNETT P J RICKERB D S | 1987 | Thin Solid Films1987，154，1： | 1 |
| 16 | Polychlorinatedbiphenyls (PCBs)in the British environment:Sinks,sources and temporal trends显示文摘 | Harrad S J Sewart A P Alcock R Boumphrey R Burnett V Davidson R D Halsall C Sanders G Waterhouse K | 1994 | Environmental Pollution1994，85，： | 1 |
| 17 | Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure显示文摘 | SHAPIRO B P CHEN H H BURNETT J C Jr | 2003 | Mayo Clin Proc2003，78，： | 1 |
| 18 | New zirconia primer im?proves bond strength of resin-based cements显示文摘 | Magne P Paranhos MP Burnett LHJr | 2010 | Dent Mater2010，26，4： | 1 |
| 19 | Associations between abortion, mental disorders, and suicidal behavior in a nationally representative sample 显示文摘 | Mota N P Burnett M Sareen J | 2010 | Can J Psychiatry2010，55，4： | 1 |
| 20 | Terminally ill cancer pa- tients' wish to hasten death 显示文摘 | Kelly B Burnett P Pelusi D | 2002 | Palliative Medicine2002，16，4： | 1 |
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