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| 1 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 2 | Biocide tolerance in bacteria 显示文摘 | Morente E O FernandezFuentes M A Burgos M J | 2013 | Int J Food Microbiol2013，162，1： | 1 |
| 3 | Se-quential connection and phase control of a high-currentrectifier optimized for copper electrowinning applications显示文摘 | WIECHMANN E P BURGOS R P HOLTZ J | 2000 | IEEE Transactions on Industrial Electronics2000，47，4： | 1 |
| 4 | Vibration analysis usintang envelope wavelet for detecting faults inthe OLTC tap selector 显示文摘 | RIVAS E BURGOS J C GARCIA-PRADA J C | 2010 | IEEE Transactions on Power Delivery2010，25，3： | 1 |
| 5 | Condition Assessment of power OLTC by vibration analysis using wavelet transform显示文摘 | RIVAS E BURGOS J C GARCIA-PRADA J C | 2009 | IEEE Transactions on Power Deliv- ery2009，24，2： | 1 |
| 6 | Vitiligo:complex segregation and linkage disequilibrium analyses with respect to microsatellite loci spanning the HLA显示文摘 | Arcos Burgos M Parodi E | 2002 | Human Gen2002，110，4： | 1 |
| 7 | Overexpression of chemokines, fibrogenic cytokines, and myofibroblasts in human membranous nephropathy 显示文摘 | MEZZANO S A DROGUETT M A BURGOS M E | 2000 | Kidney Int2000，57，1： | 1 |
| 8 | Vitiligo: complex segregation and linkage disequilibrium analyses with respect to microsatellite locispanning the HLA 显示文摘 | Arcos - Burgos M Parodi E | 2002 | Human Genetics2002，110，4： | 1 |
| 9 | EPSPS gene amplification in glyphosate‐resistant Italian ryegrass ( Lolium perenne ssp. multiflorum ) from Arkansas显示文摘 | Reiofeli A Salas Franck E Dayan Zhiqiang Pan Susan B Watson James W Dickson Robert C Scott Nilda R Burgos | 2012 | Pest. Manag. Sci2012，，9： | 1 |
| 10 | Isolation and characterisation ofsymbiotically effective Rhizobium resistant to arsenic and heavy metalsafter the toxic spill at the Aznalcollar pyrite mine 显示文摘 | Carrasco JA Armario P Pajuelo E Burgos A Caviedes MA LópezR Chamber MA Palomares AJ | 2005 | Soil Biol Biochem2005，37，6： | 1 |
| 11 | Detection and inheritance of stylar ribonucleases associated with in- compatibility alleles in apricot显示文摘 | BURGOS L PEREZ-TORNERO O BALLESTER J OIMOS E | 1998 | Sex Plant Reprod1998，11，： | 1 |
| 12 | Sequential connection and phase control of a high-current rectifier optimized for copper electrowinning applications 显示文摘 | WIECHMANN E P BURGOS R P HOLTZ J | 2000 | IEEE Trans on Industrial Electronics2000，47，4： | 1 |
| 13 | Antioxidative enzymes offer protection from chilling damage in rice plants显示文摘 | KUK Y I SHIN J S BURGOS N R HWANG T E HAN O CHO B H JUNG S GUH J O | 2003 | Crop Science2003，43，6： | 1 |
| 14 | (Micro)biological,chemical and physical properties of soils subjected to conventional or no-till management:an assessment of their quality status显示文摘 | Aon M A Sarena D E Burgos J L | 2001 | Soil & Tillage Research2001，60，： | 1 |
| 15 | Impact of cardiovascular risk factors and infl ammatory status on urinary8-OHd G in essential hypertension显示文摘 | Rosello-Lleti E de Burgos FG Morillas P | 2012 | Am J Hypertens2012，25，2： | 1 |
| 16 | Properties ofthe testicular lactate dehydregenase isoenzyme显示文摘 | Blanco A Burgos C Gerez D E | 1976 | J Biol Chem1976，153，2： | 1 |
| 17 | Algorithm based on the mesh analysis for com- puting 2-D magneto static fields by the finite difference method显示文摘 | SORRENTINO E SILVA P BURGOS J C | 2014 | International journal of electrical power & energy systems2014，62，： | 1 |
| 18 | Pancreatic neuroendocrine tumors 显示文摘 | Burgos L Burgos M E | 2004 | Rev Med Chil2004，132，5： | 1 |
| 19 | Natural remediation of an unremediated soil twelve years after a mine accident: Trace element mobility and plant composition显示文摘 | Burgos P Madejon P Madejon E | 2013 | Journal of Environmental Management2013，114，： | 1 |
| 20 | Predictive value of six risk scores for outcome after surgical repair of hip fracture in elderly patients显示文摘 | BURGOS E GOMEZ-ARNAU J I DIEZ R | 2008 | Acta Anaesthesiol Scand2008，52，1： | 1 |
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