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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | DNA electrochemical biosensors for environmental monitoring 显示文摘 | Wang J Rivas Cai G Palecek E Nielsem | 1997 | A Review Analytical Chemica Acta1997，347，12： | 1 |
| 3 | Menisci in arrays of cylinders: Numerical simulation by finite elements显示文摘 | Orr F M Scriven L E Rivas A P | 1975 | Journal Of Colloid And Interface Science1975，52，3： | 1 |
| 4 | Double sleeve uniportal video-assisted thoracoscopic lobectomy for non-small cell lung cancer 显示文摘 | GONZALEZ'-RIVAS D DELGADO M FIEIRA E | 2014 | Ann Car- diothorac Surg2014，3，2： | 1 |
| 5 | Genotoxieity study of water-soluble cationic polymers and their polymer-metal complexes with biocidal activity显示文摘 | Rivas B L Pereira E D Mondaca M A | 2003 | J Appl Polym Sci2003，87，3： | 1 |
| 6 | Vibration analysis usintang envelope wavelet for detecting faults inthe OLTC tap selector 显示文摘 | RIVAS E BURGOS J C GARCIA-PRADA J C | 2010 | IEEE Transactions on Power Delivery2010，25，3： | 1 |
| 7 | Antitumour activity of the silybin-phosphatidylcholine complex,IdB 1016,against human ovarian cancer显示文摘 | Gallo D Giacomelli S Ferlini C Raspaglio G Apollonio P Prislei S Riva A Morazzoni P Bombardelli E Scambia G | | 0，，： | 1 |
| 8 | Single-incision laparoscopic cholecystectomy:initial evaluation of a large series of patients显示文摘 | Rivas H Varela E Scott D | 2010 | Surg Endosc2010，24，6： | 1 |
| 9 | 显示文摘 | Hueso L E Rivas J Rivadulla F | 2001 | J Appl Phys2001，89，： | 1 |
| 10 | TK2 mutation presenting asindolent myopathy 显示文摘 | Paradas C Gutierrez Rios P Rivas E et ai | | NeurologyO130，8，50： | 1 |
| 11 | Single incision laparoscopic chole- cystectomy : initial evaluation of a large series of patients 显示文摘 | Rivas H Varela E Scott D | 2010 | Surg Endosc2010，24，： | 1 |
| 12 | Anaysis of Rhizobium etli and of its symbiosis with wild Phaseolus vulgaris supports coevolution in centers of host diversification显示文摘 | Aguilar OM Riva O Peltzer E | 2004 | Proceedings of the National Academy of Sciences of the USA2004，101，13： | 1 |
| 13 | Condensation in a square minichannel: application of the VOF method 显示文摘 | Bortolin S Da Riva E Del Col D | 2014 | Heat Transfer Engineering2014，35，2： | 1 |
| 14 | A TiO2/Al2O3 catalyst to improve the ozonation of oxalic acid in water显示文摘 | Rivas F J Ramon M E | 2004 | Appl Catal B:Environ2004，47，： | 1 |
| 15 | Temozoiomide and thalidomide in the treatment of glioblastoma multiforme显示文摘 | Riva M Imbesi F Beghi E | 2007 | Anticancer Res2007，27，2： | 1 |
| 16 | Single-incision laparoscopic cholecystectomy : initial evaluation of a large series of patients 显示文摘 | Rivas H Varela E Scott D | 2010 | Surg Endosc2010，24，6： | 1 |
| 17 | Condition Assessment of power OLTC by vibration analysis using wavelet transform显示文摘 | RIVAS E BURGOS J C GARCIA-PRADA J C | 2009 | IEEE Transactions on Power Deliv- ery2009，24，2： | 1 |
| 18 | A combined electrochemical and theoretical study of N,N′bis(benzimidazole2ylethyl)1,2diaminoethane as a new corrosion inhibitor for carbon steel surface显示文摘 | Guadalupe H J GarcíaOchoa E MaldonadoRivas P J | 2011 | Journal of Electroanalytical Chemistry2011，655，2： | 1 |
| 19 | Probing the genetic population structure of Trypanosoma cruzi with polymorphic microsatellites显示文摘 | Broude Natalia E Macedo Andrea M | 1998 | Proceedings of the National Academy of Sciences of the United States of America1998，95，7： | 1 |
| 20 | Anti-arrhythmic effects of amiodarone and desethylamiodarone on malignant ventricular arrhythmias arising as a consequence of ischaemia and reperfusion in the anaesthetised rat显示文摘 | RIVA E HEARSE DJ | 1989 | Cardiovasc Res1989，23，4： | 1 |
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