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| 1 | 最新治疗可延迟艾森门格综合征患者需要移植的时间显示文摘Aims: Advanced therapies(prostacyclin analogues, endothelin receptor antagonists) are successfully used in the treatment of idiopathic pulmonary arterial hypertension. In addition, patients with the Eisenmenger syndrome(ES) seem to benefit from these news drugs regarding symptoms, but there is still no evidence for changes in outcome. Methods and results: The clinical course of 43 patients(M/F 13/30, age 34.0±12.7 years), registered with unstable ES in our database, was retrospectively analysed. These patients were divided into two groups: those treated with and those treated without advanced therapy. The primary endpoint was defined as death from any cause. Death or inscription on the active waiting list of heart-lung transplantation was considered as secondary endpoint. Kaplan-Meier survival and log rank testing were performed to determine differences in outcome between the two groups. The total cohort was followed for a median period of 4.9(range 0.2-14.9) years. Mean survival time for patients treated with(n=26) and without(n=17) advanced therapy therapies were 8.5±1.5 and 8.5±0.9 years, respectively(log rank testing, P=0.31). However, the mean time to death or inscription on the active waiting list was significantly longer for patients treated with advanced therapy when compared with those without(7.8±1.0 vs. 3.4±0.9 years, P=0.006). Conclusion: For the given follow-up period, no improvement in survival time could be documented in adult patients with unstable ES treated with advanced therapy. However, we might suggest with these data that the need for heart-lung transplantation can be substantially delayed with new drugs. | Adriaenssens T. Delcroix M. Van Deyk K. Budts W. 郭俊 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 2 |
| 2 | Serum vaccine antibody concentrations in children exposed to perfluorinated compounds显示文摘 | GRANDIEAN P ANDERSEN EW BUDT J E | | 0，，04： | 1 |
| 3 | Percutaneous closure of a patent foramen ovale: single-centre experience using different types of devices and midterm outcome显示文摘 | Post MC Van Deyk K Budts W | 2005 | J Acta Cardiol2005，60，5： | 1 |
| 4 | Comprehensive care for a- dults with congenital heart disease: expanding roles for nurses 显示文摘 | Moons P De Geest S Budts W | 2002 | Eur J Cardiovasc Nurs2002，1，1： | 1 |
| 5 | Aerosol gene transfer with inducible nitric oxide synthase reduces hypoxic pulmonary hypertension and pulmonary remodeling in rats显示文摘 | Budts W Pokreisz P Nong Z | 2000 | Circulation2000，102，： | 1 |
| 6 | Restoration of the partially edentulous moutha comparison of overdentures , removable partial den- tures, fixed partial dentures and implant treatment 显示文摘 | Budt 2-Jorgensen E | 1996 | J Dent1996，24，4： | 1 |
| 7 | Patient knowledge ofand adherence to oral anticoagulation therapy after mechanicalheart - valve replacement for congenital or acquired valve defects显示文摘 | Van Damme S Van Deyk K Budts W | 2011 | Heart Lung2011，40，： | 1 |
| 8 | Patient knowledge of and adherence to oral anticoagulation therapy after mechanical heart-valve replacement foreongenital or acquired valve defects 显示文摘 | Van Damme S Van Deyk K Budts W | 2011 | Heart Lung2011，40，2： | 1 |
| 9 | New Hybrid Transition State Analog Inhibitors of HIV Protease with Peripheric C2-Symmetry显示文摘 | Stowasser B Budt K H Li J Q | 1992 | Tetrahedron Lett1992，33，： | 1 |
| 10 | Critique on the conceptualisation of quality of life: A review and evaluation of different conceptual approaches显示文摘 | Philip Moons Werner Budts Sabina De Geest | 2006 | International Journal of Nursing Studies2006，，7： | 1 |
| 11 | Patient knowledge of and adherence to oral anticoagulation therapy after mechanical heart-valve replacement for congenital or acquired valve defects显示文摘 | Sara Van Damme Kristien Van Deyk Werner Budts Peter Verhamme Philip Moons | 2011 | Heart & Lung - The Journal of Acute and Critical Care2011，，2： | 1 |
| 12 | Visualization of the intracavitary blood flow in systemic ventricles of Fontan patients by contrast echocardiogra- phy using particle image velocimetry 显示文摘 | Lampropoulos K Budts W Van de Bruaene A | 2012 | Cardiovascular Ultrasound2012，10，： | 1 |
| 13 | Duplication of the TGFBR1 gene causes features of Loeys-Dietz syndrome显示文摘 | Breckpot J Budts W De Zegher F | 2010 | Eur J Med Genet2010，53，6： | 1 |
| 14 | Critique on the conceptualization of quality of life: a review and evaluation of different conceptual approaches显示文摘 | Moons P Budts W De Geest S | 2006 | Int J Nurs Stud2006，43，7： | 1 |
| 15 | Aerosol gene transfer with inducible nitric oxide synthase reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats显示文摘 | Budts W Pokreisz P Nong Z | 2000 | Circulation2000，102，23： | 1 |
| 16 | Left main coronary artery and right pulmo- nary vein compression by a large pulmonary artery aneurysm显示文摘 | Decuypere V Delcroix M Budts W | 2004 | Heart2004，90，4： | 1 |
| 17 | Murine cytomegalovirus m142 and m143 are both required to block protein kirnse R-mediated shutdown of protein synthesis显示文摘 | Valchanova RS Picard-Maureau M Budt M | 2006 | J Virol2006，80，10： | 1 |
| 18 | Off‐label use of percutaneous pulmonary valved stents in the right ventricular outflow tract: Time to rewrite the label?显示文摘 | Derize E. Boshoff Bjorn L.M. Cools Ruth Heying Els Troost Joelle Kefer Werner Budts Marc Gewillig | 2013 | Intervent2013，，6： | 1 |
| 19 | Temporal trends in survival to adulthood among patients born with congenital heart disease from 1970 to 1992 in belgium clinical perspective显示文摘 | MOONS P BOVIJN L BUDTS W | 2010 | Circulation2010，122，22： | 1 |
| 20 | Closure of a patent foramen ovale is associated with a decrease in prevalence of migraine显示文摘 | Thijs V Herroelen L Budts WIHL | 2004 | Neurolog2004，62，： | 1 |
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