维普期刊资源整合服务平台（V6.5）

115篇 您的检索式：作者名="BOWDISH"

选中清除导出查看参考文献查看引证文献引用追踪共6页首页上一页第1页下一页末页 /6 跳转

	题名	作者	年代	出处	被引量
1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
2	Apoptosis of airway epithelial cells, human serum sensitive induction by the cathelicidin LL-37 显示文摘	Lau YE Bowdish DM Cosseau C	2006	Am J Respir Cell Mol Biol2006，34，4：	1
3	Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37 显示文摘	Lau YE Bowdish DM Cosseau C	2006	Am J Respir Cell Mol Biol2006，34，4：	1
4	Insect tolerant transgenic tomato plants显示文摘	FischhoffD A Bowdish K S Perlak F J	1987	Bio/Technology1987，5，：	1
5	Impact of LL-37 on anti-infective immunity显示文摘	BOWDISH D M DAVIDSON D J LAU Y E		0，，77：	1
6	The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes显示文摘	Bowdish D M Davidson D J Speert D P	2004	J Immunol2004，172，：	1
7	Immunomodulatory properties of defensins and cathelicidins显示文摘	Bowdish D M Davidson D J Hancock R E	2006	Curr Top Microbiol Immunol2006，306，：	1
8	A reevaluation of the role of host defence peptides in mam-malian immunity显示文摘	Bowdish DM Davidson DJ Hancock RE	2005	Current Protein and Peptide Science2005，6，：	1
9	A re-evaluation of the role of host defence peptides in mammalian immunity显示文摘	Bowdish D M E Davidson D J Hancock R E W	2005	Current Protein and Peptide Science2005，6，1：	1
10	Production of antibodies in transgenic plants 显示文摘	HIATT A CAFFERKEY R BOWDISH K	1989	Nature1989，342，：	1
11	The ha- man cationic peptide LL - 37 induces activation of the extracellular signal- regulated kinase and p38 kinase pathways in primary hu- man monocytes显示文摘	BOWDISH D M DAVIDSON D J SPEERT D P	2004	J Immunol2004，172，6：	1
12	Immunomodulatory activities of small host defense peptides显示文摘	Bowdish D M Davidson D J Scott M G	2005	Antimicrob Agents Chemother2005，49，：	1
13	Evidence for recipient derived fibroblast recruitment and activation during the development of chronic cardiac allograft rejection 显示文摘	Wu G D Tuan T L Bowdish M E	2003	Transplantation2003，76，3：	1
14	Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37显示文摘	Mookherjee N Brown KL Bowdish DM	2006	J Immunol2006，176，4：	1
15	Contribution of mesenchymal progenitor cells to tissue repair in rat cardiac allografts undergoing chronic rejection 显示文摘	Wu GD Bowdish ME Jin YS	2005	J Heart Lung Transplant2005，24，12：	1
16	Production of antibodies in transgenic plants显示文摘	Hiatt A Cafferkey R Bowdish K	1989	Nature1989，342，：	1
17	Production of antibodies in trails-genicplant显示文摘	Hiatt A Caferkey R Bowdish K	1989	Nature1989，342，：	1
18	Immunomodulatory properties of defensins and cathelicidins显示文摘	Bowdish DM Davidson DJ Hancock RE	2006	Curr Top Microbiol Immunol2006，306，：	1
19	Impact of LL-37 on anti-infective immunity 显示文摘	Bowdish D M E Davidson D J Lau Y E et ol	2005	J Leukocyte Biol2005，77，4：	1
20	Anticoagulation isan effective treatment for aortic mural thrombi显示文摘	Bowdish M Weaver F Leibman H	2002	J Vasc Surg2002，36，4：	1

返回顶部每页显示：

共6页首页上一页第1页下一页末页 /6 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示