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| 1 | Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options显示文摘Objective: Echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were significant for AE prevalence only. Conclusion: Tibetan herdsmen communities were at the highest risk of echinococcosis prevalence and should be the focus of echinococcosis control. Deworming both owned and stray dogs should be a major measure for controlling echinococcosis;treatment of wild definitive hosts should also be considered for AE endemic areas. Health education activities should be in concert with the local people's education backgrounds and languages in order to be able to improve behaviors. Further researches are needed to clarify the importance of wild hosts for AE/CE prevalence, the extent and range of the impacts of ecologic changes (overgrazing and deforestation) on the AE prevalence, and risk factors in Tibet. | Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li Xiangman Zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu | 2014 | Infectious Diseases of Poverty2014，3，1： | 35 |
| 2 | Application of GC/MS-based metabonomic profiling in studying the lipid-regulating effects of Ginkgo biloba extract on diet-induced hyperlipidemia in rats显示文摘 | Qi ZHANG Guang-ji WANG Ji-ye A Di WU Ling-ling ZHU Bo MA Yu DU | 2009 | Acta Pharmacologica Sinica2009，30，12： | 28 |
| 3 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 4 | Secondary causes of inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD),conventionally consist of Crohn’s disease(CD)and ulcerative colitis.They occur in individuals with high risk genotype for the disease in the setting of appropriate environmental factors.The pathogenesis of IBD involves a dysregulated autoimmune response to gut dysbiosis,which in turn is triggered due to exposure to various inciting environmental factors.But there is no clearly defined etiology of IBD and this type of disease is termed as“idiopathic IBD”,“classic IBD”,or“primary IBD”.We reviewed the current medical literature and found that certain etiological factors may be responsible for the development of IBD or IBD-like conditions,and we consider this form of de novo IBD as“secondary IBD”.Currently known factors that are potentially responsible for giving rise to secondary IBD are medications;bowel altering surgeries and transplantation of organs,stem cells or fecal microbiome.Medications associated with the development of secondary IBD include;immunomodulators,anti-tumor necrosis factor alpha agents,anti-interleukin agents,interferons,immune stimulating agents and checkpoint inhibitors.Colectomy can in some cases give rise to de novo CD,pouchitis of the ileal pouch,or postcolectomy enteritis syndrome.After solid organ transplantation or hematopoietic stem cell transplantation,the recipient may develop de novo IBD or IBD flare.Fecal microbiota transplantation has been widely used to treat patients suffering from recurrent Clostridium difficile infection but can also causes IBD flares. | Yezaz A Ghouri Veysel Tahan Bo Shen | 2020 | World Journal of Gastroenterology2020，26，28： | 13 |
| 5 | Gastrin,somatostatin,and experimental disturbance of the gastrointestinal tract in rats显示文摘INTRODUCTIONThe field of gastrointestinal hormones has expanded at a dizzying rate[1-4].Gastrointestinal hormones as regulatory peptides that appear to be major components of bodily integration and have important regulatory actions on physioligical function of the gastrointestinal tract .The successful isolation of some gastrointestinal hormones and the development of sensitive methods for their detection have led to the unexpected finding that they also exist in the brain . | Yong Li Yao~1 Bo Xu~2 Wan Dai Zhang~1 Yu Gang Song~1 ~1Institute of Gastrointestinal Diseases,Nanfang Hospital,First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2Department of Orthopedics Nanfang Hospital,First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaYong Li Yao graduated from First Military Mcdical University with a master degree in 1998.She now works in the Institute of Gastrointestinal Diseases,Nanfang Hospital as a doctoral candidate majoring gastrointestinal diseases and gastrointestinal hormones,she has published 8 papers. | 2001 | World Journal of Gastroenterology2001，7，3： | 12 |
| 6 | Predicting intrinsic disorder in proteins: an overview显示文摘 | Bo He Kejun Wang Yunlong Liu Bin Xue Vladimir N Uversky A Keith Dunker | 2009 | Cell Research2009，19，8： | 11 |
| 7 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 8 | GC-TOF/MS-based metabolomic profiling of estrogen deficiency-induced obesity in ovariectomized rats显示文摘 | Bo MA Qi ZHANG Guang-ji WANG Ji-ye A Di WU Ying LIU Bei CAO Lin-sheng LIU Ying-ying HU Yong-lu WANG Ya-ya ZHENG | 2011 | Acta Pharmacologica Sinica2011，32，2： | 3 |
| 9 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 10 | Sources of particulate organic matter in the Chukchi and Siberian shelves: clues from carbon and nitrogen isotopes显示文摘The stable isotopic composition(δ13C andδ15N)and carbon/nitrogen ratio(C/N)of particulate organic matter(POM)in the Chukchi and East Siberian shelves from July to September,2016 were measured to evaluate the spatial variability and origin of POM.Theδ13CPOC values were in the range of−29.5‰to−17.5‰with an average of−25.9‰±2.0‰,and theδ15NPN values ranged from 3.9‰to 13.1‰with an average of 8.0‰±1.6‰.The C/N ratios in the East Siberian shelf were generally higher than those in the Chukchi shelf,while theδ13C andδ15N values were just the opposite.Abnormally low C/N ratios(<4),lowδ13CPOC(almost−28‰)and highδ15NPN(>10‰)values were observed in the Wrangel Island polynya,which was attributed to the early bloom of small phytoplankton.The contributions of terrestrial POM,bloom-produced POM and non-bloom marine POM were estimated using a three end-member mixing model.The spatial distribution of terrestrial POM showed a high fraction in the East Siberian shelf and decreased eastward,indicating the influence of Russian rivers.The distribution of non-bloom marine POM showed a high fraction in the Chukchi shelf with the highest fraction occurring in the Bering Strait and decreased westward,suggesting the stimulation of biological production by the Pacific inflow in the Chukchi shelf.The fractions of bloom-produced POM were highest in the winter polynya and gradually decreased toward the periphery.A negative relationship between the bloom-produced POM and the sea ice meltwater inventory was observed,indicating that the net sea ice loss promotes early bloom in the polynya.Given the high fraction of bloom-produced POM,the early bloom of phytoplankton in the polynyas may play an important role on marine production and POM export in the Arctic shelves. | Renming Jia Xinyue Mu Min Chen Jing Zhu Bo Wang Xiaopeng Li A S Astakhov Minfang Zheng Yusheng Qiu | 2020 | Acta Oceanologica Sinica2020，39，9： | 2 |
| 11 | Dual module based maximum power point tracking control of photo- voltaic systems显示文摘 | JOUNG HU P JUN YOUN A BO HYUNG C | 2006 | IEEE Trans on Industrial Electronics2006，53，4： | 1 |
| 12 | FIGO 1988 versus 2009 staging for endometrial carcinoma: a comparative study on prediction of survival and stage distribution according to histologic subtype显示文摘 | Haltia UM BO tzow R Leminen A | 2014 | J Gynecol Oncol2014，25，1： | 1 |
| 13 | MicroRNAs in brain development and degeneration显示文摘 | Enciu A Popescu BO Gheorghisan-Galateanu A | 2012 | Molecular Biology Reports2012，39，3： | 1 |
| 14 | Intracortical multiplesclerosis lesions are not associatecd with increased lymphocyteinfiltration显示文摘 | Bo L Vedeler C A Nyland H | 2003 | Mult Scler2003，9，4： | 1 |
| 15 | Co administration of metformin during rFSH treatment in patients with clomiphene citrate resistant polycystic ovarian syndrome :a prospective randomized trial显示文摘 | Yarali H Yildiz BO Demirol A | 2002 | Hum Reprod2002，17，2： | 1 |
| 16 | A review of the treatm ent of chronic hepatitis C virus infection in cirrhosis显示文摘 | Vezali E Aghem o A Colom bo M | 2010 | Clin Ther2010，32，13： | 1 |
| 17 | Expression of inflammationrelated genes in endothelial cells is not directly affected by microparticles from preeclamptic patients显示文摘 | Lok C A Boing A N Reitsma P H | 2006 | J Lab Clin Med2006，147，6： | 1 |
| 18 | Diffusion- weighted magnetic resonance imaging for the assessment of fi- brosis in chronic hepatitis C 显示文摘 | Lewin M Poujol-Robert A Bo lie PY | 2007 | Hepatology2007，46，： | 1 |
| 19 | Detection of five novel GMO maize events by qualitative, multiplex PCR and fluorenscence capillary gel electrophoresis显示文摘 | Holck A Pedersen BO Heir E | 2010 | Eur Food Res Technol2010，231，： | 1 |
| 20 | The standardization of terminol-ogy of female pelvic organ prolapse and pelvic floor dysfunction 显示文摘 | Bump RC Mattiasson A Bo K | 1996 | Am J Obstet Gynecol1996，175，1： | 1 |
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