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    题名 作者 年代 出处 被引量
1Metabolomic analysts of simvastatin and fenofibrate intervention in high-lipid diet-induced hyperlipidemia rats显示文摘Qiu-yu XU Yin-hui LIU Qi ZHANG Bo MA Zhen-dong YANG Lei LIU Di YAO Guang-bo CUI Jing-jing SUN Zi-mei WU 2014Acta Pharmacologica Sinica2014,35,10:8
2Cimicifuga heracleifolia is therapeutically similar to black cohosh in relieving menopausal symptoms: evidence from pharmacological and metabolomics studies显示文摘In the market of botanical dietary supplements, Cimicifuga heracleifolia(CH) has always been considered as an adulterated species of Cimicifuga racemosa(CR), a conventional American herb with promising benefits to counteract troubles arising from the menopause. However, the detailed comparison of their therapeutic effects is lacking. In present study, the pharmacological and metabolomics studies were comparatively conducted between CH and CR in ovariectomized(OVX) female rats. Specifically, estrogen-like, anti-hyperlipidemia and anti-osteoporosis effects were evaluated through measuring serum biochemical parameters, histopathological examination and micro computed tomography(Micro-CT) scanning. At the same time, a gas chromatography-mass spectrometry(GC-MS)-based serum metabolomics method was employed to profile the metabolite compositional changes. As a result, both CR and CH displayed anti-osteoporosis and anti-hyperlipemia on menopause syndrome. Meanwhile, their potentials in improving the OVX-induced metabolic disorders were discovered. In conclusion, these results demonstrated that CH is therapeutically similar to CR in relieving menopausal symptoms and CH could be considered as a promising alternative to CR instead of an adulterant in the market of botanical dietary supplements.MIAO Lan-Yun CHU Thi Thanh Huyen LI Ping JIANG Yan LI Hui-Jun 2019Chinese Journal of Natural Medicines2019,17,6:5
3花生四烯酸及其代谢产物与围绝经期的关系显示文摘花生四烯酸是人体必需的游离脂肪酸之一,花生四烯酸及其产物在调节人体炎症反应、血管弹性、白细胞功能、骨的重塑和血小板活化中具有重要作用。新近研究发现,花生四烯酸在绝经后女性血液中的含量会发生变化,花生四烯酸及其产物与绝经后高血压、肥胖和骨质疏松等疾病有关。此外,饮食因素对绝经后血液花生四烯酸的调节起重要作用。就围绝经期前后花生四烯酸的含量变化及其可能机制和绝经后妇女饮食与体内花生四烯酸变化的关系进行综述。周之伟 王文娟 白文佩 秦丽华 2015国际妇产科学杂志2015,42,2:2
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