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| 1 | Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma显示文摘AIM: To investigate the role of cytochrome P450 (CYP) in the carcinogenesis of squamous-cell carcinoma (SCC) in human esophagus by determining expression patterns and protein levels of representative CYPs in esophageal tissue of patients with SCC and controls. METHODS: mRNA expression of CYP2E1, CYP2C, CYP3A4, and CYP3A5 was determined using RT-PCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC (n = 21) and in controls (n = 10). Protein levels of CYP2E1, CYP2C8, CYP3A4, and CYP3A5 were measured by Western blot. RESULTS: Within the group of SCC patients, mRNA expression of CYP 3A4 and CYP2C was significantly lower in malignant tissue (-39% and -74%, respectively, P < 0.05) than in normal tissue. Similar results were found in CYP3A4 protein levels. Between groups, CYP3A4, CYP3A5, and CYP2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients (4.8-, 2.9-, and 1.9-fold elevation, P < 0.05) than in controls. In contrast, CYP2E1 protein levels were significantly higher in controls than in SCC patients (+46%, P < 0.05). CONCLUSION: Significant differences exist in protein levels of certain CYPs in non-malignant esophageal tissue (e.g. CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus. | I Bergheim E Wolfgarten E Bollschweiler AH Hlscher C Bode A Parlesak | 2007 | World Journal of Gastroenterology2007，13，7： | 6 |
| 2 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009，，6： | 5 |
| 3 | Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial显示文摘 | Alan Garber Robert Henry Robert Ratner Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvera-Alvarez Paula M Hale Milan Zdravkovic Bruce Bode | 2009 | The Lancet2009，，9662： | 2 |
| 4 | Gadolinium decreases stretch- induced vulnerability to atrial fibrillation显示文摘 | Bode F Katchman A Woosley RL | 2000 | Circulation2000，101，18： | 2 |
| 5 | Characterization of conditions for the primary culture of human small intestinal epithelial cells显示文摘 | ALDHOUS M C SHMAKOV A N BODES J | 2001 | Clin Exp Immunol2001，125，1： | 1 |
| 6 | Gadolinium decreases stretch- induced vulnerability to atrial fibrillation显示文摘 | Bode F Katchman A Woosley RL | 2000 | Circulation2000，101，18： | 1 |
| 7 | Correction of the bleeding time with lyophilized platelet infusions in dogs on cardiopulmonary bypass 显示文摘 | BODE A P LUST R M READ M S | 2008 | Clin Appl Thromb Hemost2008，14，： | 1 |
| 8 | Detection of theBacillus anthracis gyrA gene by using a minor groove binder probe 显示文摘 | Hurtle W Bode E Kulesh D A | 2004 | Journal of Clinical Microbiology2004，42，1： | 1 |
| 9 | E 6 ]- Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase 显示文摘 | JEONG C H BODE A M PUGLIESE A | 2009 | Cancer Res2009，69，13： | 1 |
| 10 | Cytomegalovirus infection and coronary heart disease,results of a German case-control study显示文摘 | Hoffmeister A Bode G | 1999 | J Infect Dis1999，179，： | 1 |
| 11 | Run-to-run control and performance monitoring of overlay in semiconductor manufacturing 显示文摘 | BODE C A KO B S EDGAR T F | 2004 | Control Engineering Practice2004，12，7： | 1 |
| 12 | Catheter ablation of electrical storm due to monomorphic ventricular tachycardia in patients with nonischemic cardiomyopathy:acute results and its effect on long-term survival显示文摘 | ARYA A BODE K PIORKOWSKI C | | 0，，12： | 1 |
| 13 | Characterization of conditions for the primary culture of human small intestinal epithelial cells显示文摘 | ALDHOUS M C SHMAKOV A N BODE J | 2001 | Clin Exp Immunol2001，125，1： | 1 |
| 14 | Relative impor-tance of rehabilitation therapy characteristics on functional outcomesfor persons with stroke显示文摘 | BODE R K HEINEMANN A W SEMIK P | 2004 | Stroke2004，35，11： | 1 |
| 15 | Contraceptive efficacy and safety of DMPA-SC 显示文摘 | JAIN J JAKIMIUK A J BODE FR | 2004 | Contraception2004，70，4： | 1 |
| 16 | IgA against gut-derived endotoxins:does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease 显示文摘 | Parlesak A Schafer C Bode C | 2002 | Dig Dis Sci2002，47，4： | 1 |
| 17 | Current infection with Helieobacter pylori, but not seropositivity to Chlamydia pneu- moniae or eytomegalovirus, is associated with an atherogenie, mod- ified lipid profile 显示文摘 | Hoffmeister A Rothenbacher D Bode G | 2001 | Arterioseler Thromb Vase Biol2001，21，3： | 1 |
| 18 | An overview of the municipal waste incineration industry in Asia and the former Soviet Union显示文摘 | TIMOTHY R CROCKETT BODE M A | 1996 | Journal of Hazardous Material1996，47，： | 1 |
| 19 | The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects 显示文摘 | BODE A M DONG Z G | 2002 | Cri Rev Oncol Hematol2002，42，1： | 1 |
| 20 | Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line显示文摘 | Liu G Bode A Wang MY | 2001 | J Cancer Res2001，61，15： | 1 |
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