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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Semi-hot Stamping as an Improved Process of Hot Stamping显示文摘Reducing the forming load,deletion of springback,increasing the formability of sheets as well as producing high strength parts are the main reasons to apply hot stamping process.Hot stamping process and 22MnB5 steels are the state of the art process and grades,respectively;however novel processes and steel grades are under considerations.In the current research,behavior of the steel grade MSW1200 blanks under semi and fully hot stamping processes was characterized.During semi-hot stamping process,the blank was firstly heated to a temperature of about 650℃ and then formed and quenched in the die assembly,simultaneously.Microstructure and mechanical properties of semi and fully hot stamped blanks were studied and the results were compared with those of normally water/air quenched blanks.The hot stamped blanks attained the strength values as high as water quenched blanks.The highest ductility and consequently,the best formability were achieved for the blank which had been semi-hot stamped.It was concluded that for the mentioned steel,semi-hot stamping process could be considered as an improved thermo-mechanical process which not only guaranteed a high formability,but also led to ultra high strength values. | Malek Naderi Mostafa Ketabchi Mahmoud Abbasi Wolfgang Bleck | 2011 | Journal of Materials Science & Technology2011，27，4： | 15 |
| 3 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 4 | 晶粒尺寸对高锰奥氏体TWIP钢氢脆行为的影响显示文摘主要研究了晶粒尺寸对Fe-17Mn-1Al-0.6CTWIP钢的氢脆行为的影响。原始材料经过不同的热处理制度,得到晶粒尺寸为17和45μm的材料。通过慢拉伸试验研究氢质量分数在0~0.001%材料的氢脆敏感性。试验结果表明,充氢后的试验材料比未充氢试验材料易发生氢脆,充氢后的试验材料断裂强度和断裂应变均降低。随着晶粒尺寸的增大,试验材料的氢脆敏感性增强。在氢质量分数为0.001%,晶粒尺寸增加到45μm时,应变损失率为17%,随着晶粒尺寸的增大,氢脆敏感性增加的原因是晶粒尺寸较大的材料孪晶较早出现,孪晶密度较大,同时单位晶界氢质量分数增加。 | 昝娜 丁桦 骆小鹏 唐正友 BLECK Wolfgang | 2016 | 中国冶金2016，26，1： | 10 |
| 5 | Control of Strain Hardening Behavior in High-Mn Austenitic Steels显示文摘Austenitic high-Mn steels with Mn contents between approximately 15 and 30 wt% gain much interest because of their excellent mechanical properties and the option for adjusting strain hardening behavior due to different deformation mechanisms. 2D and 3D composition-dependent stacking fault energy(SFE) maps indicate the effect of chemical composition and temperature on SFE and consequently on the deformation mechanisms. Three steels with different chemical compositions and the same or different SFE are characterized in quasi-static tensile tests. The control parameters of strain hardening behavior in the high-Mn austenitic steels are described, and consequences for future developments are discussed. | Wenwen Song Tobias Ingendahl Wolfgang Bleck | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，3： | 9 |
| 6 | Improvement of center segregation in high-carbon steel billets using soft reduction显示文摘Center segregation is the main reason for cup fracture of high-carbon wire rod during drawing. Therefore, to continuously produce cast billets with very low center segregation is an important objective. The soft reduction technology is considered to be an effective method to minimize center segregation. To elucidate the effect of soft reduction on the internal quality of high-carbon steel billets, soft reduction was applied with different solid fractions in the core area of billets in a laboratory casting machine. A coupled temperature/displacement finite element model was developed to calculate the solid fraction using the commercial software ABAQUS.Center segregation, center porosity, homogeneity of elements, and equiaxed crystal zone were obviously improved by applying soft reduction, especially when the solid fraction was less than 1.0. The optimal results were obtained when the solid fraction was approximately 0.9. | Wenjun Wang Xionggang Hu Linxin Ning Raimund Bülte Wolfgang Bleck | 2006 | Journal of University of Science and Technology Beijing2006，13，6： | 5 |
| 7 | New insights into the properties of high-manganese steel显示文摘In the Collaborative Research Centre 761’s“Steel ab initio-quantum mechanics guided design of new Fe based materials,”scientists and engineers from RWTH Aachen University and the Max Planck Institute for Iron Research conducted research on mechanism-controlled material development with a particular focus on high-manganese alloyed steels.From 2007 to 2019,a total of 55 partial projects and four transfer projects with industrial participation(some running until 2021)have studied material and process design as well as material characterization.The basic idea of the Collaborative Research Centre was to develop a new methodological approach to the design of structural materials.This paper focuses on selected results with respect to the mechanical properties of high-manganese steels,their underlying physical phenomena,and the specific characterization and modeling tools used for this new class of materials.These steels have microstructures that require characterization by the use of modern methods at the nm-scale.Along the process routes,the generation of segregations must be taken into account.Finally,the mechanical properties show a characteristic temperature dependence and peculiarities in their fracture behavior.The mechanical properties and especially bake hardening are affected by short-range ordering phenomena.The strain hardening can be adjusted in a never-before-possible range,which makes these steels attractive for demanding sheet-steel applications. | Wolfgang Bleck | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，5： | 5 |
| 8 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 9 | Initial experience from a combination of systemic and regional chemotherapy in the treatment of patients with nonresectable cholangiocellular carcinoma in the liver显示文摘AIM: In nonresectable cholangiocellular carcinoma (CCC)therapeutic options are limited. Recently, systemic chemotherapy has shown response rates of up to 30%.Additional regional therapy of the arterially hyper vascularized hepatic tumors might represent a rational approach in an attempt to further improve response and palliation. Hence, a protocol combining transarterial chemoembolization and systemic chemotherapy was applied in patients with CCC limited to the liver.METHODS: Eight patients (6 women, 2 men, mean age 62 years) with nonresectable CCC received systemic chemotherapy (gemcitabine 1 000 mg/m2) and additional transarterial chemoembolization procedures (50 mg/m2cisplatin, 50 mg/m2 doxorubicin, up to 600 mg degradable starch microspheres). Clinical follow-up of patients, tumor markers, CT and ultrasound were performed to evaluate maximum response and toxicity.RESULTS: Both systemic and regional therapies were tolerated well; no severe toxicity (WHO Ⅲ/Ⅳ) was encountered. Nausea and fever were the most commonly observed side effects. A progressive rarefication of the intrahepatic arteries limited the maximum number of chemoembolization procedures in 4 patients. A median of 2 chemoembolization cycles (range, 1-3) and a median of 6.5 gemcitabine cycles (range, 4-11) were administered.Complete responses were not achieved. As maximum response, partial responses were achieved in 3 cases,stable diseases in 5 cases. Two patients died from progressive disease after 9 and 10 mo. Six patients are still alive. The current median survival is 12 mo (range, 9-18); the median time to tumor progression is 7 mo (range, 3-18). Seven patients suffered from tumor-related symptoms prior to therapy, 3 of these experienced a treatment-related clinical relief. In one patient the tumor became resectable under therapy and was successfully removed after 10 mo.CONCLUSION: The present results indicate that a combination of systemic gemcitabine therapy and repeated regional chemoembolizations is well tolerated and may enhance the effect of palliation in a selected group of patients with intrahepatic nonresectable CCC. | Timm Kirchhoff Lars Zender Sonja Merkesdal Bernd Frericks Nisar Malek Joerg Bleck Stefan Kubicka Stefan Baus Ajay Chavan Michael P.Manns Michael Galanski | 2005 | World Journal of Gastroenterology2005，11，8： | 3 |
| 10 | Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites显示文摘 | Sonja Welsch Sven Miller Ines Romero-Brey Andreas Merz Christopher K.E. Bleck Paul Walther Stephen D. Fuller Claude Antony Jacomine Krijnse-Locker Ralf Bartenschlager | 2009 | Cell Host & Microbe2009，，： | 2 |
| 11 | It's time to revise the definition of status epilepticus显示文摘 | Lowenstein DH Bleck TP Macdonald RL | 1999 | Epilepsia1999，40，1： | 2 |
| 12 | Correlates of long-term physical activity adherence in women显示文摘Background: Little is known about the factors that may influence women's adherence to moderate-to-vigorous physical activity(MVPA) using longitudinal data. The purpose of this study was to examine the correlates of long-term physical activity(PA) participation among women.Methods: Female data from Waves I, III, and IV(n = 5381) of the National Longitudinal Study of Adolescent to Adult Health(Add Health) were used for the analysis. The outcome of PA adherence was operationalized as(1) consistently physically active(at least 5 instances during the week)in both Waves III and IV(during adulthood), and(2) consistently not physically active or only physically active in either Wave III or IV. Predictor variables from Wave I(during adolescence) included race/ethnicity, PA level, self-perception of being physically fit, general health status, attempt to change weight, parents' income level, parents' education, well-being, depression, access to PA resources, days of physical education(PE), and grade level. Crude and adjusted logistic regression models were utilized to estimate the adjusted odds ratio(a OR) and 95% confidence interval(95%CI) for the outcome variable.Results: PA levels during adolescence significantly predicted PA adherence(a OR = 1.67, 95%CI: 1.35–2.05). Additionally, wanting to lose weight(a OR = 1.49, 95%CI: 1.20–1.85), using fitness center in the neighborhood(a OR = 1.29, 95%CI: 1.05–1.58), and having 5 days of PE a week(a OR = 1.48, 95%CI: 1.09–2.02) were significant predictors. Women who did not perceive being physically fit(a OR = 0.65, 95%CI: 0.44–0.95)and Black, non-Hispanics(a OR = 0.60, 95%CI: 0.44–0.82) were less likely to adhere to PA.Conclusion: The findings suggested that physically active adolescents were more likely to become active adults. Future research should address interventions(e.g., PE program, community resources) that may promote lifetime PA in women, with the goal of decreasing morbidity and mortality. | Haichun Sun Cheryl A. Vamos Sara S.B. Flory Rita DeBate Erika L. Thompson Jennifer Bleck | 2017 | Journal of Sport and Health Science2017，6，4： | 2 |
| 13 | It's time to revise the definition of satus epileptics 显示文摘 | Lowenstein DH Bleck T MacDonald RL | 1999 | Epilepsia1999，40，1： | 1 |
| 14 | Survival rate in patients with hepatocellular carcinoma:a restrospective analysis of 389 patients显示文摘 | Greten TF Papendorf F Bleck JS | 2005 | Br J Cancer2005，92，10： | 1 |
| 15 | Demanding pressed parts producible galvanized high strength steels with good cold-formability 显示文摘 | Bleck W | 1990 | IND- ANZ1990，112，19： | 1 |
| 16 | Ncurogenie puhnonary edema and other mechanisms of impaired oxygenation after aneurysmal subaraehnoid hemorrhage 显示文摘 | Vespa PM Bleck TP | 2004 | Neuroerit Care2004，1，2： | 1 |
| 17 | Effect of precipitation on hot formability of high nitrogen steels 显示文摘 | Erisir E Prahl U Bleck W | 2010 | Materials science and engineering A2010，528，： | 1 |
| 18 | Market transparency and the accounting regime显示文摘 | Bleck A Liu X | 2007 | Journal of Accounting Research2007，45，： | 1 |
| 19 | It's time to revise the definition of status epilepticus显示文摘 | Lowenstein DH Bleck T Macdonald RL | 1999 | Epilepsia1999，40，1： | 1 |
| 20 | Refractory status epileptics in 2001 显示文摘 | Bleck TP | 2002 | Arch Neurol2002，59，2： | 1 |
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