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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Root-Specific Transcript Profiling of Contrasting Rice Genotypes in Response to Salinity Stress显示文摘提高的咸度强加渗透并且离子毒性在生活上强调房间并且要求大量的回答以便启用植物幸存。在在米饭( Oryza sativa )介绍抄本层次的更早的工作上造 FL478 射击,盐容忍的 indica recombinant 生来的线,和 IR29 ,盐敏感的栽培变种,抄本层次在这二就职的根以及在二另外的盐容忍的 indica 遗传型的根被比较, landrace Pokkali 和 recombinant 生来的线 IR63731 。这研究的目的是比较抄本在敏感并且容忍的线以便多半识别基因涉及工厂咸度忍耐,而非响应咸度本身。有到咸度忍耐的已知的连接的几个基因家庭的抄本侧面被描述(例如 HKT, NHX ) 。通过他们的盐应答,抄本层次,或 chromosomal 地点识别的一套基因的通常认为的功能(即在为咸度忍耐的 QTL 下面) 也被讨论。最后,在 FL478 的 Saltol 区域的父母起源进一步被调查。总的来说,介绍的数据集看起来柔韧,这个系统能为涉及咸度忍耐的新奇基因的发现提供可靠策略,似乎可能。 | Olivier Cotsaftis Darren Plett Alexander A.T. Johnson Harkamal Walia Clyde Wilson Abdelbagi M. Ismail Timothy J. Close Mark Tester Ute Baumann | 2011 | Molecular Plant2011，4，1： | 14 |
| 3 | 130例骨髓增生异常综合征(难治性血细胞减少)和获得性再生障碍性贫血患儿的临床及病理特征分析显示文摘目的 探讨儿童难治性血细胞减少(RCC)和获得性再生障碍性贫血(AAA)的临床特征和病理特征,为更好地诊断、鉴别诊断及治疗两种疾病患儿提供理论依据.方法 以130例RCC或AAA患儿为研究对象,回顾性分析其临床资料及骨髓活检病理特征.结果 130例患儿中78例(60.0%)为RCC,52例(40.0%)为AAA.RCC组患儿的外周血白细胞计数、中性粒细胞绝对值计数、血小板计数、血红蛋白、网织红细胞计数均显著高于AAA组(P<0.01).RCC组患儿骨髓活检示增生低下,84.6%(66/78)的患儿骨髓造血细胞比例介于20%~ 60%,98.7% (77/78)的患儿造血细胞呈典型的“不均匀片状”分布、红系造血细胞簇状分布伴核左移,61.5%(48/78)的患儿可见小巨核细胞.AAA组患儿骨髓活检示增生极为低下,88.5%(46/52)的患儿骨髓造血细胞比例<5%,98.1%(51/52)的患儿骨髓中未见巨核细胞.给予环孢素±兔-抗胸腺细胞球蛋白±雄激素±中药的免疫抑制方案治疗,RCC和AAA患儿3个月总有效率分别为59.5%和26.9% (P=0.011),6个月总有效率为75.0%和38.1%(P=0.007).结论 RCC患儿外周血细胞减少及骨髓增生减低程度较AAA轻,其骨髓造血细胞呈“不均匀片状”分布、红系造血细胞簇状分布伴核左移及小巨核细胞的出现为鉴别于AAA的典型病理学特征.RCC和AAA患儿接受免疫抑制方案治疗均可获得确切疗效,但RCC患儿的总有效率较AAA高. | 覃霞 Irith Baumann 陈静 沈萍 陈洁枫 殷敏智 | 2014 | 中华血液学杂志2014，35，8： | 5 |
| 4 | Protein misfolding in neurodegenerative diseases:implications and strategies显示文摘A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse.Therapeutic options are currently being explored that target different steps in the production and processing of proteins implicated in neurodegenerative disease,including synthesis,chaperone-assisted folding and trafficking,and degradation via the proteasome and autophagy pathways.Other therapies,like mTOR inhibitors and activators of the heat shock response,can rebalance the entire proteostatic network.However,there are major challenges that impact the development of novel therapies,including incomplete knowledge of druggable disease targets and their mechanism of action as well as a lack of biomarkers to monitor disease progression and therapeutic response.A notable development is the creation of collaborative ecosystems that include patients,clinicians,basic and translational researchers,foundations and regulatory agencies to promote scientific rigor and clinical data to accelerate the development of therapies that prevent,reverse or delay the progression of neurodegenerative proteinopathies. | Patrick Sweeney Hyunsun Park Marc Baumann John Dunlop Judith Frydman Ron Kopito Alexander McCampbell Gabrielle Leblanc Anjli Venkateswaran Antti Nurmi Robert Hodgson | 2017 | Translational Neurodegeneration2017，6，1： | 4 |
| 5 | 滑动多层磁共振成像在直肠间质瘤分期中的应用价值显示文摘目的探讨滑动多层(sliding multislice,SMS)磁共振成像(MRI)在胃肠道间质瘤(gastrointestinal stromal tumours,GIST)腹部分期中的应用价值和潜力。方法2005年9月至2008年1月8例由组织学和免疫组化检测证实的直肠GIST患者,均接受盆腔静止高分辨率MRI和腹部SMS MRI检查进行治疗前分期。在盆腔静止高分辨率MRI采用T2-TSE序列检查后,利用SMS技术的T1加权增强FLASH-2D序列在1 min内检查整个腹部。分析图像,分别了解直肠GIST原发部位情况及腹部远处转移情况。结果盆腔静止高分辨率MRI检查成功确定所有患者直肠GIST的大小、范围及局部侵犯程度,肿瘤最大直径介于1.7~11.0 cm。SMS MRI检查的图像质量能够满足对可能的肝转移灶、转移淋巴结、肠系膜转移灶和骨转移灶的评价。结论腹部SMS MRI联合盆腔静止高分辨率MRI可以在一次检查中完成直肠GIST的腹部分期。 | 熊斌 Arnd-Oliver Schaefer Tobias Baumann 冯敢生 Mathias Langer | 2009 | 华中科技大学学报(医学版)2009，38，2： | 4 |
| 6 | 中德矿山环境修复条件比较研究——以德国奥斯那不吕克Piesberg和中国淮南大通矿为例显示文摘以德国奥斯那不吕克Piesberg和中国淮南大通矿区为研究对象,采用比较研究的方法分别从矿山工程背景、自然地理条件、矿山煤矸石及土壤质地特征、人文社会环境条件等方面对中德矿山环境修复条件进行差异分析。研究结果显示:Piesberg矿区的气候条件、人文社会环境条件优于大通矿区,有利于矿区已遭受破坏的环境修复;但该矿区内地面分布的煤矸石因含较多的黄铁矿而呈较高的酸性,酸性土壤和较低的土壤有效含水量,以及该区较低的地下水水位等因素条件显然劣于淮南大通矿区,不利于矿区生态环境的修复;Piesberg矿区的环境修复现状好于淮南矿区的主要因素是因为该矿区内较少的人为活动干扰而使得生态环境得到稳定的自然修复。 | 严家平 徐良骥 阮淑娴 Helmut Meuser Simone Baumann | 2015 | 中国煤炭地质2015，27，11： | 4 |
| 7 | From crystalluria to kidney stones,some physicochemical aspects of calcium nephrolithiasis显示文摘Nephrolithiasis seems to be the result of crystal formation,aggregation and retention in the kidney during crystalluria.These processes have to occur within the short urinary transit time through the kidney being in the order of few minutes.Recently much work was done on rather qualitative aspects of nephrolithiasis like genetics,metabolism and morphology.In this review we try to provide some quantitative information on urinary supersaturation with respect to stone minerals,especially Ca oxalate(CaO x),on the formation and aggregation of Ca Ox crystals and on crystal retention in the kidney.The paper is centered on idiopathic Ca nephrolithiasis being the most frequent stone disease with only partially known pathogenesis.New aspects of the role of urinary macromolecules in stone formation and of the mechanism of crystal aggregation are provided. | Johannes M Baumann Beat Affolter | 2014 | World Journal of Nephrology2014，3，4： | 4 |
| 8 | Transition after pediatric liver transplantation-Perceptions of adults, adolescents and parents显示文摘AIM To develop a locally adapted, patient-focused transitionprogram, we evaluated the perceptions of adult and adolescent patients and parents regarding transitionprograms and transfer.METHODS We evaluated these perceptions by analyzing the responses of pre-transfer adolescents(n = 57), their parents(n = 57) and post-transfer adults(n = 138) from a cohort of pediatric-liver-transplant-patients using a self-designed questionnaire. Furthermore, we compared a responder group with a non-responder group as well as the provided answers with baseline characteristics and clinical outcomes to exclude selection bias, characterize high-risk patients for nonadherence and test for gender differences. Included in our study were all pre-transfer liver transplant and combined liver-kidney transplant recipients aged 11-19 currently under our care and their parents, as well as all post-transfer liver transplant and combined liverkidney transplant recipients aged ≥ 17 years who had received a liver transplant and were treated at our center during childhood.RESULTS Fifty-seven(24 female) pre-transfer patients who received a transplant in the previous 8-186 mo(mean 93.9 mo, median 92 mo, SD 53.8 mo) and 138(57 female) post-transfer patients who received a transplant in the preceding 2-29 years(mean 15.6 years, median 17, SD 6.90) met the inclusion criteria. A total of 67% of pre-transfer patients(71% of female; 64% of male; P = 0.78) and their parents replied. Additionally, 54% of post-transfer patients(26% of female; 48% of male; P = 0.01) replied. No differences in clinical outcomes were observed between the responder and non-responder groups, and responses did not differ significantly based on clinical complication rates, although they did differ based on gender and the location of medical follow-up after transfer. Adolescents were generally ambivalent toward transition programs. However, adults strongly supported transition programs. CONCLUSION Transition programs need to be developed in close collaboration with adolescents. The best clinical practices regarding transition should respect local circumstances, gender and the location of post-transfer medical follow-up. | Norman Junge Katarina Migal Imeke Goldschmidt Ulrich Baumann | 2017 | World Journal of Gastroenterology2017，23，13： | 2 |
| 9 | Interactionb etween primisulfuron and selected soil-applied insecticides in corn (Zea mays) 显示文摘 | Biediger D L Baumann PA WeaverDN | 1992 | Weed Technol1992，6，： | 2 |
| 10 | The CSIRO automatic tester for length and strength 显示文摘 | Tompson R L Andrews M W Baumann A B | 1988 | J Text Inst1988，，79： | 2 |
| 11 | Preddctive factors in radiotheraphy for non-mall cell lung cancer:presentstatus 显示文摘 | Choi N Baumann M Flentjie M | 2001 | Lung Cancer2001，3，1： | 2 |
| 12 | Influence of regional pollution outflow on the concentrations of fine particulate matter and visibility in the coastal area of southern China显示文摘 | Hing-Cho Cheung Tao Wang Karstern Baumann Hai Guo | 2005 | Atmospheric Environment2005，，34： | 2 |
| 13 | Antibiotic Resistance in Salmonella Isolates from Imported Chicken Carcasses in Bhutan and from Pig Carcasses in Vietnam显示文摘 | Ellerbroek L Narapati D Tai N Phu Poosaran N Pinthong R Sirimalaisuwan A Tshering P Fries R Zessin K-h Baumann M Schroeter A | 2010 | Journal of Food Protection2010，，2： | 2 |
| 14 | Acoustic nonlinearities in adhesive joints显示文摘 | M. Rothenfusser M. Mayr J. Baumann | 2000 | Ultrasonics2000，，1： | 2 |
| 15 | 奥斯纳布吕克地区不同基质矿山废弃地的植被修复差异性显示文摘以德国奥斯纳布吕克地区3种基质类型矿山废弃地作为研究对象,分别对粉煤灰场地、煤矸石山、选煤厂尾矿及煤泥水沉积区3种基质类型的工矿废弃地土壤进行分层采样和理化性质指标分析,对比研究了矿区不同类型工矿废弃地不同基质的自然修复能力以及在进行植被重建时需要修复的土壤理化性质指标。结果显示:以煤矸石为主的场地自然修复能力高于粉煤灰基质和选煤厂尾矿及煤泥水沉积区基质类型。Helmstedt粉煤灰场地周边生长着一些芦苇;煤矸石场地Ibbenbueren和Piesberg山区自然生长着一些灌木;煤泥水沉积区因选煤厂仍在生产,沉积区无植物生长。 | 严家平 阮淑娴1 Helmut Meuser Simone Baumann 范廷玉 | 2015 | 煤田地质与勘探2015，43，5： | 2 |
| 16 | Treatment of spontane-ous pneumothorax, a more aggressive approach 显示文摘 | MICHAEL H BAUMANN CHARLIE STRANGE | 1997 | Chest1997，112，： | 1 |
| 17 | Inhi- bition of Denitrification Activity but not of mRNA Induction in Paracoccus denitrificans by Nitrite at a Suboptimal pH 显示文摘 | BAUMANN B VAN DER MEER J R SNOZZI M | 1997 | Antonie van Leeuwenhoek1997，72，： | 1 |
| 18 | Linkagen disequilibrium relationships among four polymorphisms within the human fibrinogen gene cluster显示文摘 | Henschen AH | 1994 | J Hum Genet1994，94，： | 1 |
| 19 | CD24 expression causes the acquisition of multiple cellular properties associ- ated with tumor growth and metastasis 显示文摘 | Baumann P Cremers N Kroese F | 2005 | Cancer Res2005，65，10： | 1 |
| 20 | DNA self-recognition in the structure of Potl bound to telomeric single-stranded DNA显示文摘 | Lei M Podell E R Baumann P | 2003 | Nature2003，426，6963： | 1 |
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