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| 1 | New perspectives in occult hepatitis C virus infection显示文摘Occult hepatitis C virus (HCV) infection, defined as the presence of HCV RNA in liver and in peripheral blood mononuclear cells (PBMCs) in the absence of detectable viral RNA in serum by standard assays, can be found in anti-HCV positive patients with normal serum levels of liver enzymes and in anti-HCV negative patients with persistently elevated liver enzymes of unknown etiology. Occult HCV infection is distributed worldwide and all HCV genotypes seem to be involved in this infection. Occult hepatitis C has been found not only in anti-HCV positive subjects with normal values of liver enzymes or in chronic hepatitis of unknown origin but also in several groups at risk for HCV infection such as hemodialysis patients or family members of patients with occult HCV. This occult infection has been reported also in healthy populations without evidence of liver disease. Occult HCV infection seems to be less aggressive than chronic hepatitis C although patients affected by occult HCV may develop liver cirrhosis and even hepatocellular carcinoma. Thus, anti-HCV negative patients with occult HCV may benefit from antiviral therapy with pegylated-interferon plus ribavirin. The persistence of very low levels of HCV RNA in serum and in PBMCs, along with the maintenance of specific T-cell responses against HCV-antigens observed during a long-term follow-up of patients with occult hepatitis C, indicate that occult HCV is a persistent infection that is not spontaneously eradicated. This is an updated report on diagnosis, epidemiology and clinical implications of occult HCV with special emphasis on anti-HCV negative cases. | Vicente Carreño Javier Bartolomé Inmaculada Castillo Juan Antonio Quiroga | 2012 | World Journal of Gastroenterology2012，18，23： | 5 |
| 2 | Biliary cystadenoma显示文摘The diagnosis of cystadenoma is rare, even more so when located in the extrahepatic bile duct.Unspeciflc clinical signs may lead this pathology to be misdiagnosed.The need for pathological anatomy in order to distinguish cystadenomas from simple biliary cysts is crucial.The most usual treatment nowadays is resection of the bile duct, together with cholecystectomy and Roux-en-Y reconstruction. | Miguel A Hernandez Bartolome Sagrario Fuerte Ruiz Israel Manzanedo Romero Beatriz Ramos Lojo Ignacio Rodriguez Prieto Luis Gimenez Alvira Rosario Granados Carreo Manuel Limones Esteban | 2009 | World Journal of Gastroenterology2009，15，28： | 4 |
| 3 | Li2SnO3 branched nano- and microstructures with intense and broadband white-light emission显示文摘Exploiting the synergy between microstructure, morphology and dimensions by suitable nanomaterial engineeri ng, can effectively upgrade the physical properties and material performances. Li2SnO3 elongated nano- and microstructures in form of belts, wires, rods and branched structures have been fabricated by a vapor-solid method at temperatures ranging from 700 to 900℃ using metallic Sn and Li2CO3 as precursors. The achievement of these new morphologies can face challenging applications for Li2SnO3, not only in the field of energy storage, but also as building blocks in optoelectronic devices. The micro? and nanostructures grown at 700 and 800℃ correspond to monoclinic Li2SnO3, while at 900℃ complex Li2S nO/SnO2 core-shell microstructures are grow n, as con firmed by X-ray diffractio n and Rama n spectroscopy. Transmission electron microscopy reveals structural disorder related to stacking faults in some of the branched structures, which is associated with the prese nee of the low-temperature phase of L12S nO3. The luminescent resp onse of these structures is domi nated by in tense emissi ons at 2, 2.5 and 3 eV, almost completely covering the whole range of the visible light spectrum. As a result, white-light emission is obtained without the need of phosphors or complex quantum well heterostructures. Enhanced functionality in applications such as in light-emitting devices could be exploited based on the high luminescenee intensity observed in some of the analysed Li2SnO3 structures. | Miguel Garcia-Tecedor Javier Bartolome David Maestre Achim Trampert Ana Cremades | 2019 | Nano Research2019，12，2： | 3 |
| 4 | Comparing surgical efficiencies between phacoemulsification systems: a single surgeon retrospective study of 2000 eyes显示文摘AIM: To compare under similar conditions intraoperative surgical efficiencies metrics between an active fluidics and a gravity based phacoemulsification systems.METHODS: Adult patients who were diagnosed with a cataract that compromised visual acuity inferior to 20/40 were included in the study. Patients were excluded from the study if they had a history of severe retinal disorders, clinically significant corneal endothelial dystrophy or history of corneal disease. All phacoemulsification surgeries were performed by a single surgeon. Both phacoemulsification systems used the 0.9 mm 45-degree aspiration bypass system Intrepid Balanced tip and the 0.9 mm Intrepid Ultra infusion sleeve. All cataracts were classified using the Lens Opacities Classification System III, cumulative dissipated energy(CDE) and aspiration fluids were measured in each surgery.RESULTS: Totally 2000 eyes were included in the study. Phacoemulsification was performed in 1000(50%) eyes with an active fluid dynamics system and in 1000(50%) eyes with a gravity-based fluidic system. Mean CDE until fracture of the lens was 1.1 and 1.9 percent-seconds and total mean CDE used was 5.6 and 7.2 percent-seconds using an active fluidics dynamics system and gravity-based fluidic system, respectively(P<0.001). Mean aspiration fluids used were 70 m L using an active fluidics dynamics system and 85 m L using a gravity-based fluidic system(P<0.001).CONCLUSION: This study evidences that surgeries performed under similar conditions(same surgeon, phaco tip and sleeve) with the active fluidics dynamics system required significantly lower CDE and aspiration fluids. | Luis Escaf-Jaraba Jorge Escobar-DiazGranados Bartolomé Valdemarín | 2022 | International Journal of Ophthalmology(English edition)2022，15，4： | 2 |
| 5 | Perspectives of the potential implications of wine polyphenols on human oral and gut microbiota显示文摘 | T. Requena M. Monagas M.A. Pozo-Bayón P.J. Martín-álvarez B. Bartolomé R. del Campo M. ávila M.C. Martínez-Cuesta C. Peláez M.V. Moreno-Arribas | 2010 | Trends in Food Science & Technology2010，，7： | 2 |
| 6 | Determination of pesticides by capillary chromatography and SERS detection using a novel Silver-Quantum dots “sponge” nanocomposite显示文摘 | Carolina Carrillo-Carrión Bartolomé M. Simonet Miguel Valcárcel Bernhard Lendl | 2012 | Journal of Chromatography A2012，，： | 2 |
| 7 | Stromal cell-derived factor-lalpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities 显示文摘 | Bartolome RA Galvez BG Longo N | 2004 | Cancer Res2004，64，7： | 1 |
| 8 | Influence of machine symmetry on reduction of cogging torque in permanent-magnet brushless motors 显示文摘 | BRETON C BARTOLOME J BENITO J A | 2000 | IEEE Transactions on Magnetics2000，36，5： | 1 |
| 9 | Enzymic Release of Ferulic Acid from Barley Spent Grain显示文摘 | Bartolome B Faulds C B | 1997 | Journal of Cereal Science1997，，25： | 1 |
| 10 | Sensitivity to glutamate neurotoxicity in different developmental periods of the rat cochlea显示文摘 | Carricondo F Bartolome MV Vicente-Torres MA | 2002 | Adv Otorhinolaryngol2002，59，： | 1 |
| 11 | Hepatitis B virus DNA in serum and blood cells of hepatitis B surface antigen-negative hemodialysis patients and staff显示文摘 | Cabrerizo M Bartolome J De Sequera P | 1997 | J Am SocNephrol1997，8，： | 1 |
| 12 | Comorbidities, Patient Knowledge, and Disease Management in a National Sample of Patients with COPD显示文摘 | R. Graham Barr Bartolome R. Celli David M. Mannino Thomas Petty Stephen I. Rennard Frank C. Sciurba James K. Stoller Byron M. Thomashow Gerard M. Turino | 2009 | The American Journal of Medicine2009，，4： | 1 |
| 13 | High expression of IL-13 receptor alpha2 in colorectal canceris associated with invasion, liver metastasis,and poor prog-nosis显示文摘 | Barderas R Bartolome RA Fernandez-Acenero MJ | 2012 | Cancer Res2012，72，： | 1 |
| 14 | The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually re- quired during melanoma metastasis to lungs 显示文摘 | Bartolome RA Ferreiro S Miquilena-Colina ME | 2009 | Am J Pathol2009，174，2： | 1 |
| 15 | High critical current YBazCu307 artificial joints using Ag foils as welding agent显示文摘 | Iliescu S Granados X Bartolome E | 2004 | Super''cond Sci Technol2004，17，： | 1 |
| 16 | Detection of proteins encoded by the pre-S region of hepatitis B virus in the sera of HBsAg carriers:relation to viral replication显示文摘 | Ibarra MZ Mora I Bartolome J | 1989 | Liver1989，9，3： | 1 |
| 17 | Zirconia/stainless-steel continuous functionally graded material 显示文摘 | LOPEZ-ESTEBAN S BARTOLOME J F PECHARROMAN C | 2002 | J Eur Ceram Soc2002，22，16： | 1 |
| 18 | Age of spent Octopus vulgaris and stress mark analysis using beaks of wild individuals显示文摘 | PERALES-RAYA C JURADO-RUZAFA A BARTOLOMé A | 2014 | Hydrobiologia2014，725，1： | 1 |
| 19 | Extending Applicability of the Oxygen Radical Absorbance capacity(ORAC2Fluorescein)Assay显示文摘 | Davalos A Gomez C C Bartolome B | 2004 | J Agric Food Chem2004，52，1： | 1 |
| 20 | Release of ferufic acid from cereal residues by barley enzymatic extract显示文摘 | SANCHO A I BARTOLOME B GOMEZ-CORDOVES C | 2001 | Journal of Cereal Science2001，34，2： | 1 |
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