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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | Butter adulteration, de- tection of hydrogenated fats in butter fat by measurement of cis-trans conjugated unsaturation 显示文摘 | BARTLET J C CHAPMAN D G | 1961 | Agric Food Chem1961，9，1： | 1 |
| 3 | Use of a reporter gene to follow high pressure signal transduction in the deep sea bacterium Photo bacterium SS9显示文摘 | CHI E BARTLET D H | 1993 | Bacteriol1993，175，： | 1 |
| 4 | The responses of the cabbage seed weevil Ceutorhynchus assimilis to volatile compounds from oilseed rape in a linear track olfactometer显示文摘 | Bartlet E Blight M M Lane P | 1997 | Entomologia Experimentalis et Applicata1997，85，： | 1 |
| 5 | Modal verification of force determination for measuring vibration loads显示文摘 | BARTLET'F F D FLANNELLY W D | 1979 | Journal of the American Helicopter Society1979，19，4： | 1 |
| 6 | The importance of Chlamydia pneumoniae as a pathogen: the 1996 Consensus Conference on Chlamydia pneumoniae Infections显示文摘 | File TM Bartlet JG Cassell GH | 1997 | Infect Dis Clin Pratice1997，6，2： | 1 |
| 7 | Kinetic analysis of the rapid intra operative parathyroid hormone as say in patients during operatio for hyperparathyroidism 显示文摘 | Libutti SK Alcxander HR Bartlet DL | 1999 | Surgery1999，126，6： | 1 |
| 8 | Use of a reporter gene to follow high pressure signal transduction in the deep sea bacterium photo bacterium SS9显示文摘 | Chi E Bartlet D H | 1993 | Bacteriol1993，175，： | 1 |
| 9 | Type Ⅰ interferon gene therapy protects against cytomegalovims induced myocarditis显示文摘 | Cull VS Bartlet EJ James CM | 2002 | Immunology2002，106，3： | 1 |
| 10 | Medical Management of HIV Infection显示文摘 | John G Bartlet Joel E Gallant | 2003 | Johns Hopkins University School of Medicine2003，，： | 1 |
| 11 | Parr-Dobrzanski, The strobilurin fungicides显示文摘 | Bartlet D W Clough J M Godwin J R | 2002 | Pest Manag Sci2002，58，7： | 1 |
| 12 | Antennal contact che- mosensilla in Psylliodes chrysocephala responding to crucifer- ous allelochemieals显示文摘 | Isidoro N Bartlet E Ziesmann J | 1998 | Physiological Entomology1998，23，2： | 1 |
| 13 | Thermodynamics of Surface Morphology显示文摘 | Williams E D Bartlet N C | 1991 | Scinence1991，251，： | 1 |
| 14 | The Imporlanee of chlamydia pnemrmniae as a pathogen:the 1996 Con- sensus Conference on Chlamydia Pneumoniae Infections 显示文摘 | File TM Bartlet JG Cassell GH | 1997 | Infect Dis CA in Pratiec1997，14，6： | 1 |
| 15 | Electrochemical deposition of macroporous magnetic networks using colloidal templates 显示文摘 | PHILIP N BARTLET T MOHAMED A | 2003 | J Mater Chem2003，13，： | 1 |
| 16 | MNCs:Get Off the Reorganization Merry-Go-Round显示文摘 | Bartlet C A | 1983 | Harvard Business Review1983，，2： | 1 |
| 17 | New support vector algorithms显示文摘 | Scholkopf B Smola A Bartlet P | 2000 | Neural Computation2000，12，5： | 1 |
| 18 | Antennal glands in PsyUiodes chrysocephala, and their possible role in reproductive behaviour 显示文摘 | BARTLET E ISIDORO N WILLIAMS I H | 1994 | Physiological Entomology1994，19，4： | 1 |
| 19 | Wound-induced increases in the glucosinolate content of oilseed rape and their effect on subsequent herbivory by a crucifer specialist显示文摘 | Elspeth Bartlet Guy Kiddie Ingrid Williams | | Entomologia Experimentalis et Applicatal0，91，： | 1 |
| 20 | Normal- pressure hydrocephalus: Diagnosis and patient selection for shunt surgery显示文摘 | Wood JH Bartlet D James AE | 1974 | Neurology1974，24，6： | 1 |
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