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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Landscape eco- logical assessment: a tool for integrating biodiversity issues in strategic environmental assessment and plan- ning 显示文摘 | Mortberg U M Ballots B Knol W C | 2007 | Journal of Environmental Management2007，8，2： | 1 |
| 3 | Auto-antibodies in autoimmune hep- atitis: anti-smooth muscle antibodies (ASMA)显示文摘 | JOHANET C BALLOT E | 2012 | Clin Res Hepatol Gastroenterol2012，36，2： | 1 |
| 4 | Antibodies to soluble liver antigen: an additional marker in type 1 autoimmune hepatitis显示文摘 | Ballot E Homberg JC Johanet C | 2000 | J Hepatol2000，33，2： | 1 |
| 5 | Apoptosis-related mitochondrial dysfunction defines human monocyte-derived dendritic cells with impaired immuno-stimulatory capacities显示文摘 | CASTERA L HATZFELD-CHARBONNIER A S BALLOT C | 2009 | Journal of Cellular and Molecular Medicine2009，13，7： | 1 |
| 6 | The serum inhibin B concentration and reference ranges in normozoospermia显示文摘 | BARBOTIN A L BALLOT C SIGALA J | 2015 | Eur J Endocrinol2015，14，： | 1 |
| 7 | Exploiting mito- chondrial dysfunction for effective elimination of imatinib - resist- ant leukemic cells显示文摘 | KLUZA J JENDOUBI M BALLOT C | 2011 | PLoS One2011，6，21： | 1 |
| 8 | Auto-antibodies in autoimmune hepatitis:antismooth muscle antibodies (ASMA)显示文摘 | Johanet C Ballot E | | 0，，： | 1 |
| 9 | Detection on immunoblot of new proteins from the microsomal fraction recognized by anti - liver- kidney microsome antibodies type 1 显示文摘 | Desbes A Auger C | 1996 | Clin Immunol Immunopathol1996，80，： | 1 |
| 10 | Diagnostic value of anti-F-actin antibodies in a French multicenter study显示文摘 | CHRETIEN-LEPRINCE P BALLOT E ANDRE C | 2005 | Ann N Y Acad Sci2005，1050，： | 1 |
| 11 | Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D显示文摘 | Ballot C Kluza J Martoriati A | | 0，，12： | 1 |
| 12 | Overcoming chemoresistance of non-small cell lung carcinoma through restoration of an AIF- dependent apoptotic pathway显示文摘 | Gallego MA Ballot C Kluza J | 2008 | Oncogene2008，27，： | 1 |
| 13 | Serum 1,3-betaD-Glucan as-say in the diagnosis of invasive fungal disease in neonates 显示文摘 | Mackay C A Ballot D EPerovic 0 | 2011 | Ped-iatr Rep2011，3，2： | 1 |
| 14 | Landscape Ecological Assessment: A Tool for Integrating Biodiversity Issues in Strategic Environmental Assessment and Planning显示文摘 | Mortberg U M Ballots B Knol W C | 2007 | Journal of Environmental Management2007，82，： | 1 |
| 15 | Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D显示文摘 | Ballot C Kluza J Martoriati A | 2009 | Mol Cancer Ther2009，8，12： | 1 |
| 16 | Landscape ecological assessment: A tool for integrating biodiversity issues in strategic environmental assessment and planning 显示文摘 | Mortberg U M Ballots B Knol W C | 2007 | Journal of Environmental Management2007，82，： | 1 |
| 17 | Diagnostic value of anti-F-actin antibodies in a French multicenter study显示文摘 | Chretien-Leprince P Ballot E Andre C | 2005 | Ann N Y Acad Sci2005，1050，1： | 1 |
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