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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 3 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 4 | CD 64 distinguishes macrophages from dendritic cells in the gut and reveals the T h1‐inducing role of mesenteric lymph node macrophages during colitis显示文摘 | Samira Tamoutounour Sandrine Henri Hugues Lelouard Béatrice de Bovis Colin de Haar C. Janneke van der Woude Andrea M. Woltman Yasmin Reyal Dominique Bonnet Dorine Sichien Calum C. Bain Allan McI. Mowat Caetano Reis e Sousa Lionel F. Poulin Bernard Malisse | 2012 | Eur J Immunol2012，，12： | 2 |
| 5 | Evaluation of a Chemiluminescence Method for Measuring Alkaline Phosphatase Activity in Whole Milk of Multiple Species and Bovine Dairy Drinks:Interlaboratory Study显示文摘 | BAIN B BELLA M BERGMAN S | 2006 | Journal of AOAC International2006，89，： | 1 |
| 6 | Giant benign esophageal schwannoma requiring esophagectomy显示文摘 | Park B J Carrasquillo J Bains M S | 2006 | Ann Thorac Surg2006，82，1： | 1 |
| 7 | The natural flow regime--A paradigm for river conservation and restoration 显示文摘 | Poff N L Allan J D Bain M B | 1997 | Bioscience1997，47，： | 1 |
| 8 | Screening criteria for beta thalassaemia trait in pregnant women显示文摘 | Rogers M Phelan L Bain B | 1995 | J Cl in Pathol1995，48，11： | 1 |
| 9 | The natural flow regime :a paradigm for river conservation and restoration 显示文摘 | Poff L N Allan D Bain M B | 1997 | Bioscience1997，47，： | 1 |
| 10 | The natural flow regime: A paradigm for river conservation and restoration 显示文摘 | Poff N L Allan J D Bain M B | 1997 | Bioscience1997，47，11： | 1 |
| 11 | The natural flow regime--a paradigm for river conservation and restoration 显示文摘 | Poff N L Allan J D Bain M B | 1997 | Bioscience1997，47，： | 1 |
| 12 | The natural flow regime: a paradigm for river conservation and restoration显示文摘 | Poff N L Allan J D Bain M B | 1997 | Bioscience1997，47，11： | 1 |
| 13 | A coordinate meas- uring machine vision system 显示文摘 | LIAO J B WU M H BAINES R W | 1999 | Computers in Industry1999，38，3： | 1 |
| 14 | A European consensus report on blood cell identification : terminology utilized and morphological diagnosis concordance among 28 experts from 17 countries within the European LeukemiaNet network WP10, on behalf of the ELN Morphology Faculty 显示文摘 | Zini G Bain B Bettelheim P | 2010 | Br J Haematol2010，151，4： | 1 |
| 15 | The Natural Flow Regime: A Paradigm for River Conservation and Restoration显示文摘 | Poff N L Allan J D Bain M B | 1997 | BioScience1997，47，11： | 1 |
| 16 | The role of ankle arthroscopy on the surgical management of ankle fractures 显示文摘 | Thordarson D B Bains R Shepherd L | 2001 | FootAnkle Int2001，22，2： | 1 |
| 17 | Aquatic ecosystem protection and restoration:advances in methods for assessment and evaluation显示文摘 | Bain M B Harig A L Loucks D P | 2000 | Environmental Science & Policy2000，，3： | 1 |
| 18 | The natural flow regime:a paradigm for river conservation and restoration显示文摘 | Poffln Allan D Bain M B | | 0，，： | 1 |
| 19 | The natural flow re- gime, a paradigm for river conservation and restoration 显示文摘 | Poff L N Allan D J Bain B M | 1997 | Bioscience1997，47，11： | 1 |
| 20 | Natural flow regime-a paradigm for river conservation and restoration 显示文摘 | Poff N L Allan J D Bain M B | 1997 | Bioscience1997，47，11： | 1 |
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