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| 1 | Effects of quaternary ammonium chain length on the antibacterial and remineralizing effects of a calcium phosphate nanocomposite显示文摘Composites containing nanoparticles of amorphous calcium phosphate(NACP)remineralize tooth lesions and inhibit caries.A recent study synthesized quaternary ammonium methacrylates(QAMs)with chain lengths(CLs)of 3–18 and determined their effects on a bonding agent.This study aimed to incorporate these QAMs into NACP nanocomposites for the first time to simultaneously endow the material with antibacterial and remineralizing capabilities and to investigate the effects of the CL on the mechanical and biofilm properties.Five QAMs were synthesized:DMAPM(CL3),DMAHM(CL6),DMADDM(CL12),DMAHDM(CL16),and DMAODM(CL18).Each QAM was incorporated into a composite containing 20%NACP and 50%glass fillers.A dental plaque microcosm biofilm model was used to evaluate the antibacterial activity.The flexural strength and elastic modulus of nanocomposites with QAMs matched those of a commercial control composite(n 5 6;P.0.1).Increasing the CL from 3 to 16 greatly enhanced the antibacterial activity of the NACP nanocomposite(P,0.05);further increasing the CL to 18 decreased the antibacterial potency.The NACP nanocomposite with a CL of 16 exhibited biofilm metabolic activity and acid production that were 10-fold lesser than those of the control composite.The NACP nanocomposite with a CL of 16 produced 2-log decreases in the colony-forming units(CFU)of total microorganisms,total streptococci,and mutans streptococci.In conclusion,QAMs with CLs of 3–18 were synthesized and incorporated into an NACP nanocomposite for the first time to simultaneously endow the material with antibacterial and remineralization capabilities.Increasing the CL reduced the metabolic activity and acid production of biofilms and caused a 2-log decrease in CFU without compromising the mechanical properties.Nanocomposites exhibiting strong anti-biofilm activity,remineralization effects,and mechanical properties are promising materials for tooth restorations that inhibit caries. | Ke Zhang Lei Cheng Michael D Weir Yu-Xing Bai Hockin HK Xu | 2016 | International Journal of Oral Science2016，8，1： | 13 |
| 2 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 3 | Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement显示文摘White spot lesions(WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate(NACP) with long-term calcium(Ca) and phosphate(P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACPrechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release.The rechargeable cement consisted of pyromellitic glycerol dimethacrylate(PMGDM) and ethoxylated bisphenol A dimethacrylate(EBPADMA). NACP was mixed into the resin at 40% by mass. Specimens were tested for orthodontic bracket shear bond strength(SBS) to enamel, Ca and P ion initial release, recharge and re-release. The new orthodontic cement exhibited an SBS similar to commercial orthodontic cement without CaP release(P40.1). Specimens after one recharge treatment(e.g., 1 min immersion in recharge solution repeating three times in one day, referred to as '1 min 3 times') exhibited a substantial and continuous re-release of Ca and P ions for 14 days without further recharge. The ion re-release did not decrease with increasing the number of recharge/re-release cycles(P40.1). The ion re-release concentrations at 14 days versus various recharge treatments were as follows: 1 min 3 times43 min 2 times41 min 2 times46 min 1 time43 min 1 time41 min 1 time. In conclusion, although previous studies have shown that NACP nanocomposite remineralized tooth lesions and inhibited caries, the present study developed the first orthodontic cement with Ca and P ion recharge and long-term release capability. This NACP-rechargeable orthodontic cement is a promising therapy to inhibit enamel demineralization and WSLs around orthodontic brackets. | Xian-Ju Xie Dan Xing Lin Wang Han Zhou Michael D Weir Yu-Xing Bai Hockin HK Xu | 2017 | International Journal of Oral Science2017，9，1： | 3 |
| 4 | Fracture spacing in layered rocks: a new explanation based on the stress transition显示文摘 | Taixu Bai David D Pollard | 1999 | Journal of Structural Geology1999，，1： | 3 |
| 5 | Progresses on SAR Remote Sensing of Tropical Forests:Forest Biomass Retrieval and Analysis of Changing Weather Conditions显示文摘This paper is intended to report on the progresses made during the Dragon-4 project Three and Four-Dimensional Topographic Measurement and Validation(ID:32278),sub-project Multi-baseline SAR Processing for 3 D/4 D Reconstruction(ID:322782).The work here reported focuses on two important aspects of SAR remote sensing of tropical forests,namely the retrieval of forest biomass and the assessment of effects due to changing weather conditions.Recent studies have shown that by using SAR tomography the backscattered power at 30 m layer above the ground is linearly correlated to the forest Above Ground Biomass(AGB).However,the two parameters that determine this linear relationship might vary for different tropical forest sites.For purpose of solving this problem,we investigate the possibility of using Li DAR derived AGB to help training the two parameters.Experimental results obtained by processing data from the Tropi SAR campaign support the feasibility of the proposed concept.This analysis is complemented by an assessment of the impact of changing weather conditions on tomographic imaging,for which we simulate BIOMASS repeat pass tomography using ground-based Tropi SCAT data with a revisit time of 3 days and rainy days included.The resulting backscattered power variation at 30 m is within 1.5 d B.For this forest site,this error is translated into an AGB error of about 50~80 t/hm^(2),which is 20%or less of forest AGB. | Stefano TEBALDINI Xinwei YANG Yu BAI Mauro Mariotti D’ALESSANDRO Mingsheng LIAO Wen YANG | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 2 |
| 6 | YAG laser percussion drilling of a functional multi-layer thin plate 显示文摘 | WANG A H WANG W Y BAI Z K XIE C S ZENG D W SONG W L | 2007 | Optics & Laser Technology2007，39，： | 1 |
| 7 | Rosiglitazone impacts negatively on bone by promoting osteoblastf osteocyte apoptosis 显示文摘 | Soreceanu MA Miao D Bai XY | 2004 | J Endocrinol2004，183，： | 1 |
| 8 | Optimum simple step-stress accelerated life tests with censoring显示文摘 | Kim M S Lee S H | 1989 | IEEE Trans Reliability1989，38，5： | 1 |
| 9 | Characteristics of gas-solids fluidizad beds in different flow regimes显示文摘 | Bai D Issangya Y S Grace J R | 1999 | Industrial Engineering Chemistry Research1999，38，： | 1 |
| 10 | Proposed nomenclature for quantify-ing subdivisions of the bronchial wall显示文摘 | Bai A Eidelman D H Hogg J C | 1994 | J Appl Physiol1994，77，2： | 1 |
| 11 | Electrochemical and XPS studies on the aqueous corrosion resistance of niobium-implanted zircaloy-4显示文摘 | Chen X W Bai X D Xu J | 2002 | Journal of Materials Science Letters2002，21，22： | 1 |
| 12 | Comprehensive scanning of somatic mitoehondrial DNA mutations in breast cancer 显示文摘 | Tan D J Bai R K Wang L J C | 2002 | Cancer Res2002，62，4： | 1 |
| 13 | 查看详情显示文摘 | Shi X Chen L D Bai S Q | | 0，，： | 1 |
| 14 | The autosomal dominant hypophosphatemic rickets R176Q mutation in fibro-blast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency显示文摘 | Bai XY Miao D Goltzman D Karaplis AC | | 0，，： | 1 |
| 15 | Transient coupled heat transfer in multilayer non-gray semitransparent media with reflective foils显示文摘 | Bai D Fan X J | | 0，，02： | 1 |
| 16 | Simultaneous desulfurization and denitrification of flue gas by ·OH radicals produced from O2-and water vapor in a duct显示文摘 | BAI M D ZHANG Z T BAI M D | 2012 | Environmental Science&Technology2012，46，10： | 1 |
| 17 | Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage 显示文摘 | Nikolic WV Bai Y Obregon D | 2007 | Proc Natl Acad Sci USA2007，104，7： | 1 |
| 18 | No eigenvalues outside the support of the limiting spectral distribution of large dimensional sample covariance matrices显示文摘 | BAI Z D SILVERSTIEN J W | 1998 | Ann Probab1998，，26： | 1 |
| 19 | Dynamic data reconciliation: Ahemative to Lalman filter 显示文摘 | BAI SH H THIBAULT J MCLEAN D D | 2006 | Journal of Process Control2006，16，： | 1 |
| 20 | Effects of L-lysine supplementation of diets with different protein levels and sources on channel catfish, lctalurus punctatus ( Rafinesque )显示文摘 | Bai S C Gatlin D M | 1994 | Aquaculture and Fisheries Management1994，25，： | 1 |
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