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| 1 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 2 | Differential immune regulation of activated T cells between cutaneous and mucosal leishmaniasis as a model for pathogenesis显示文摘 | Carvalho LP Passos S Bacellar O | | 0，，05： | 1 |
| 3 | Down regulaton of IFN-gamma production in patients with recurrent vaginal candidiasis显示文摘 | CARVALHO L P BACELLAR O NEVES N | 2002 | J Allergy Clin Immol2002，109，1： | 1 |
| 4 | Evidence of a T helper type 2 activation in human schistosomiasis 显示文摘 | Araujo MI de Jesus AR Bacellar O | 1996 | Eur J Immunol1996，26，6： | 1 |
| 5 | Downregulation of IFN- gamma production in patients with recurrent vaginal candidiasis 显示文摘 | Carvalho LP Bacellar O Neves N | 2002 | Allergy Clin Immunol2002，109，1： | 1 |
| 6 | Evidence of a T helper type 2 activation in human schistosomiasis显示文摘 | Araujo MI de Jesus AR Bacellar O | 1996 | Eur J Immunol1996，26，6： | 1 |
| 7 | Downregulation of IFN-gamma production in patients with recurrent vaginal candidiasis显示文摘 | Carvalho LP Bacellar O Neves N | 2002 | J Allergy C/in Immunol2002，109，1： | 1 |
| 8 | Down regulation of IFN-/ production in patients with recurrent vaginal candidiasis 显示文摘 | Carvalho LP Bacellar O Nevers N | 2002 | J Allergy Clin Immunol2002，109，1： | 1 |
| 9 | Dowrtregulation of IFN - garmna production in patients with recurrent vaginal candidiasis显示文摘 | CARVALHO L P BACELLAR O NEVES N | 2002 | J Allergy Clin Immunol2002，109，1： | 1 |
| 10 | IL-10 and IL-12 are the main regulatory cytokines in visceral leishmaniasis显示文摘 | Bacellar O D'oliveira A Jr Jeronimo S | 2000 | Cytokine2000，12，8： | 1 |
| 11 | Down regulation of IFN-gamma production in patients with recurrent vaginal candidiasis显示文摘 | Carvalho L P Bacellar O Neves N | 2002 | J Allergy Clin Immol2002，109，1： | 1 |
| 12 | Downregulation of IFN-gamma production in patients with recurrent vaginal candidiasis显示文摘 | Carvalho LP Bacellar O Neves N | 2012 | J Allergy Clin mmunol2012，109，1： | 1 |
| 13 | Downregulation of IFN-gamma production in patients with recurrent vaginal candidiasis显示文摘 | Carvalho L P Bacellar O Neves N | 2002 | J Allergy Clin Immunol2002，109，1： | 1 |
| 14 | Downregulation of IFN-ganna production in patients with recurrent vaginal candidiasis 显示文摘 | Carvalho LP Bacellar O Neves N | 2002 | Clin Immnol2002，109，1： | 1 |
| 15 | Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection显示文摘 | Araujo C Bacellar O | 2002 | Clin Infect Dis2002，34，11： | 1 |
| 16 | IL-10 and IL-12 are the main regulatory cytokine cytokines in visceral eishmaniasis显示文摘 | BACELLAR O D IVERA A J IERONIMO S | 2002 | Cytokine2002，12，8： | 1 |
| 17 | Downregulation of IFN-gamma production in patients with recurrent vaginal candidiasis显示文摘 | Carvalho LP Bacellar O Neves N | 2002 | J Allergy Clin Immnol2002，109，1： | 1 |
| 18 | Evidence of a T helper type 2 activation in human schistosomiasis显示文摘 | Araujo MI de Jesus AR Bacellar O | 1996 | Eur J Immunol1996，26，6： | 1 |
| 19 | Downregulation of IFN-gartmaa production in patients with recurrent vaginal candidiasis 显示文摘 | Carvalho LP Bacellar O Neves N | 2002 | J Allergy Clin Immnol2002，109，1： | 1 |
| 20 | Downregulation of IFN- gamma production in patients with recurrent vaginal eandidiasis显示文摘 | Carvalho LP Bacellar O Nevers N | 2002 | J Allergy Clin Immunol2002，109，1： | 1 |
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