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| 1 | Aminoglycoside-modifying enzymes:mechanisms of catalytic processes and inhibition显示文摘 | AZUCENA E MOBASHERY S | 2001 | Drug Resist Updat2001，4，2： | 1 |
| 2 | Aminoglycosidesmodified by resistance enzymes display diminishedbinding to the bacterial ribosomal aminoacyl-tRNAsite显示文摘 | LLANO S B AZUCENA E F J ICOTRA L P | 2002 | ChemBiol2002，9，4： | 1 |
| 3 | Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition 显示文摘 | Azucena E Mobashery S | 2001 | Drug Resist Updat2001，4，2： | 1 |
| 4 | Aminogtycoside-modifying enzymes:mechanisms of catalytic processes and inhibition显示文摘 | Azucena E Mobashery S | 2001 | Drug Resist Updat2001，4，2： | 1 |
| 5 | Species of agave with antimicrobial activity against selected pathogenic bacteria and fungi显示文摘 | ANGELES V S JULIA V SANTOS G NORMA H AZUCENA O CATALINA R | 2008 | World J Microbiol Biotcchnol2008，24，： | 1 |
| 6 | Aminoglycoside-modifying enzymes: mechamisms of catalytic processes and inhibition 显示文摘 | Azucena E Mobashery S | 2004 | Drug Resist Updates2004，4，： | 1 |
| 7 | Aminoglycoside-modifying en- zymes mechanisms of catalytic processes and inhibition显示文摘 | Azucena E Mobashery S | 2001 | Drug Resist Update2001，4，2： | 1 |
| 8 | Nitrio oxide supplementation ameliorates dextran sulfate sodium-induced colitis in mice显示文摘 | Azucena S Meritxell G Antonio S | 2002 | Lab Invest2002，82，5： | 1 |
| 9 | Aminoglycoside-modifying enzymes ~ Mechanisms of catalytic processes and inhi- bition显示文摘 | Azucena E Mobashery S | 2001 | Drug Resist Updut2001，4，2： | 1 |
| 10 | Properties of a bifunctional bacterial antibiotic resistance enzyme that cataly- zes ATP-dependent 2'-phosphorylation and acetyl - CoA-dependent 6'-acetylation of aminoglycosides显示文摘 | AZUCENA E GRAPSAS I MOBASHERY S | 1997 | Am Chem Soe1997，，119： | 1 |
| 11 | Prevalence and Characteristics of Enteropathogenic Escherichia coli with the eae Gene in Diarrhoeic Rabbits显示文摘 | Jesús E. Blanco Miguel Blanco Jorge Blanco Azucena Mora Luis Balaguer Luis Cuervo Carlos Balsalobre Francisco Mu?oa | 1997 | Microbiology and Immunology1997，，2： | 1 |
| 12 | Amino- glycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site显示文摘 | LLANO S B AZUCENA E F KOTRA L P | 2002 | Chemistry Biology2002，9，4： | 1 |
| 13 | Aminoglycoside - modifying enzymes: mechanisms of catalytic processes and inhibition 显示文摘 | Azucena E Mobashery S | 2001 | Drug Resist Updat2001，4，2： | 1 |
| 14 | Aminoglycoside- modifying enzynms:mechanisms of catalytic processes and inhibition 显示文摘 | Azucena E Mobashery S | 2001 | Drug Resist Updat2001，4，2： | 1 |
| 15 | Serotypes of Escherichia coli isolated from septicaemic chickens in Galicia (Northwest Spain)显示文摘 | Jesús E Blanco Miguel Blanco Azucena Mora Wim H Jansen Vidal Garc??a Mar??a L Vázquez Jorge Blanco | 1998 | Veterinary Microbiology1998，，3： | 1 |
| 16 | Serotypes of Escherichia coli isolated from septicaemic chickens in Galicia (Northwest Spain)显示文摘 | Jesús E Blanco Miguel Blanco Azucena Mora Wim H Jansen Vidal Garc??a Mar??a L Vázquez Jorge Blanco | 1998 | Veterinary Microbiology1998，，3： | 1 |
| 17 | Evolution of lipopolysaccharide (LPS) recognition and signaling:Fish TLR4 does not recognize LPS and negatively regulates NF-{kappa}B activation显示文摘 | Maria P S Francisca A P Azucena L M | 2009 | J Immunol2009，182，： | 1 |
| 18 | Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition显示文摘 | Azucena E Mobashery S | 2001 | Drug Resist Updat2001，4，2： | 1 |
| 19 | Bats and their vital ecosystem services:a global review显示文摘Bats play crucial ecosystem services as seed dispersers,pollinators,controllers of insects,and nutrient recyclers.However,there has not been a thorough global review evaluating these roles in bats across all biogeographical regions of the world.We reviewed the literature published during the last two decades and identified 283 relevant studies:78 dealt with the control of potential insect pests by bats,80 related to the suppression of other arthropods,60 on the dispersal of native or endemic seeds,11 dealt with the dispersal of seeds of introduced plants,29 on the pollination of native or endemic plants,1 study on pollination of introduced plants,and 24 on the use of guano as fertilizer.Our literature search showed that queries combining the terms“seed dispersal,”“insectivorous bats,”“nectarivorous bats,”“use of guano,”and“ecosystem services”returned 577 studies,but half were experimental in nature.We found that the evaluation of ecosystem services by bats has been mostly conducted in the Neotropical and Palearctic regions.To detect differences across relevant studies,and to explain trends in the study of ecosystem services provided by bats,we performed generalized linear mixed models(GLMM)fitted with a Poisson distribution to analyze potential differences among sampling methods.We identified 409 bat species that provide ecosystem services,752 insect species consumed by bats and 549 plant species either dispersed or pollinated by bats.Our review summarizes the importance of conserving bat populations and the ecological services they provide,which is especially important during the current pandemic. | Leidy Azucena RAMÍREZ-FRÁNCEL Leidy Viviana GARCÍA-HERRERA Sergio LOSADA-PRADO Gladys REINOSO-FLÓREZ Alfonso SÁNCHEZ-HERNÁNDEZ Sergio ESTRADA-VILLEGAS Burton KLIM Giovany GUEVARA | 2022 | Integrative Zoology2022，17，1： | 0 |
| 20 | Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn's disease显示文摘BACKGROUND Identifying predictors of therapeutic response is the cornerstone of personalized medicine.AIM To identify predictors of long-term mucosal healing(MH) in patients with Crohn's disease(CD) treated with tumor necrosis factor α(TNF-α) inhibitors.METHODS Prospective single center study. Consecutive patients with clinically active CD requiring treatment with a TNF-α inhibitor were included. A baseline segmental CD Endoscopic Index of Severity(CDEIS) ≥ 10 in at least one segment or the presence of ulcerations were required for inclusion. Clinical, biological and endoscopic data were obtained at baseline, weeks 14 and 46. Endoscopic response(ER) was defined as a decrease ≥ 50% from baseline CDEIS and MH as partial CDEIS ≤ 5 in all segments.RESULTS Of 62 patients were included. At baseline, median CD Activity Index and CDEIS were 201 and 6.7, respectively with a significant reduction after one year of treatment(53 and 3.0 respectively, P < 0.001). At week 14, 56% of patients achieved ER and 34% MH. At week 46, the corresponding percentages were 52%and 44%. Baseline disease characteristics or biomarkers did not predict MH. A decrease from baseline CDEIS at week 14 of at least 80% was the best predictor of MH at week 46(59% sensitivity and 91% specificity; area under the curve =0.778).CONCLUSION Clinical and biomarker data are not useful predictors of response to TNF-αinhibitors in CD, whereas ER to induction therapy, defined as 80% reduction in global CDEIS, is a robust predictor of long-term MH. Achievement of this endoscopic endpoint may be considered as a therapeutic target for anti-TNF-αtherapy. | Ignacio Alfaro Maria Carme Masamunt Nuria Planell Alicia López-García Jesús Castro Marta Gallego Rebeca Barastegui Angel Giner Alejandro Vara Azucena Salas Elena Ricart Julián Panés Ingrid Ordás | 2019 | World Journal of Gastroenterology2019，25，14： | 0 |
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