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| 1 | Antioxidant, antimicrobial and cytotoxic potential of condensed tannins from Leucaena leucocephala hybrid-Rendang显示文摘Condensed tannins(CTs)are one of the promising compounds due to their potentially health-promoting qualities.In this study,CTs were extracted from a Leucaena leucocephala hybrid-Rendang and subjected to various biological studies including antioxidant(using Ferric reducing antioxidant power(FRAP),DPPH and ABTS radical scavenging assay),anti-microbial(against different pathogens)and cytotoxic activities(toward human breast adenocarcinoma(MCF-7),human colon carcinoma(HT29),human cervical carcinoma(HeLa)and human liver carcinoma(HepG2)cell lines)in cancer cells through in vitro experiments.The structural characteristics and purity of CTs extract were determined using 13C NMR.The results showed that CTs exhibited higher in vitro antioxidant activities(2257.12±80.55 mg TEAC/g extract,605.3±1.82 mg TEAC/g extract and 1014.03±1.20 mg TEAC/g extract in FRAP,ABTS and DPPH assay,respectively)and demonstrated anti-microbial activities toward selected Gram’s positive and Gram’s negative bacteria tested with MIC and MBC value at 6.25–50 mg/mL.Furthermore,among other selected cancer cells,CTs also demonstrated cytotoxic activity toward human breast cancer cells(MCF-7)(IC50=38.33±2.08mg/mL).Characteristic of apoptosis such as cell shrinkage,nuclear condensation and apoptotic bodies were shown in MCF-7.These preliminary investigations have provided scientific rationale to use CTs as an alternative therapy for various oxidative and inflammatory associated diseases.©2016 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Mazni Abu Zarin Ho Yin Wan Azizul Isha Nurdin Armania | 2016 | Food Science and Human Wellness2016，5，2： | 9 |
| 2 | Putrescine, spermidine, and spermine play distinct roles in rice salt tolerance显示文摘Polyamines(PAs) play diverse roles in plant growth and development,as well as responses to environmental stimuli.In this study,the effects of PAs on rice salt tolerance were investigated.Salt stress resulted in the alteration of endogenous PAs levels in rice roots and leaves,where spermidine(Spd) and spermine(Spm) contents were increased,and putrescine(Put) content was decreased.RT-qPCR analysis revealed that PAs biosynthesis-related genes ADC1,ODC,and Arginase were significantly downregulated by salt treatment;however,SAMDC transcription was significantly upregulated.Exogenous Spm enhanced rice salt tolerance remarkably;however,exogenous Put and Spd undermined rice salt tolerance.Transgenic rice plants overexpressing SAMDC display a higher ratio of Spm/(Put+Spd) and enhanced salt tolerance.Salt stress also increased polyamine oxidase activities in rice,resulting in elevated reactive oxygen species(ROS) production.Our findings revealed that accumulation of Put and Spd substantially reduced salt tolerance in rice,likely by facilitating ROS production;whereas,conversion of Put and Spd to Spm contributes to rice salt tolerance. | Md Azizul ISlam PANG Jin-huan MENG Fan-wei LI Ya-wen XU Ning YANG Chao LIU Jun | 2020 | Journal of Integrative Agriculture2020，19，3： | 5 |
| 3 | Regulation of enolase activation to promote neural protection and regeneration in spinal cord injury显示文摘Spinal cord injury(SCI)is a debilitating condition characterized by damage to the spinal cord resulting in loss of function,mobility,and sensation with no U.S.Food and Drug Administration-approved cure.Enolase,a multifunctional glycolytic enzyme upregulated after SCI,promotes pro-and anti-inflammatory events and regulates functional recovery in SCI.Enolase is normally expressed in the cytosol,but the expression is upregulated at the cell surface following cellular injury,promoting glial cell activation and signal transduction pathway activation.SCI-induced microglia activation triggers pro-inflammatory mediators at the injury site,activating other immune cells and metabolic events,i.e.,Rho-associated kinase,contributing to the neuroinflammation found in SCI.Enolase surface expression also activates cathepsin X,resulting in cleavage of the C-terminal end of neuron-specific enolase(NSE)and non-neuronal enolase(NNE).Fully functional enolase is necessary as NSE/NNE C-terminal proteins activate many neurotrophic processes,i.e.,the plasminogen activation system,phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B,and mitogen-activated protein kinase/extracellular signal-regulated kinase.Studies here suggest an enolase inhibitor,ENOblock,attenuates the activation of Rho-associated kinase,which may decrease glial cell activation and promote functional recovery following SCI.Also,ENOblock inhibits cathepsin X,which may help prevent the cleavage of the neurotrophic C-terminal protein allowing full plasminogen activation and phosphatidylinositol-4,5-bisphosphate 3-kinase/mitogen-activated protein kinase activity.The combined NSE/cathepsin X inhibition may serve as a potential therapeutic strategy for preventing neuroinflammation/degeneration and promoting neural cell regeneration and recovery following SCI.The role of cell membrane-expressed enolase and associated metabolic events should be investigated to determine if the same strategies can be applied to other neurodegenerative diseases.Hence,this review discusses the importance of enolase activation and inhibition as a potential therapeutic target following SCI to promote neuronal survival and regeneration. | Hannah MMcCoy Rachel Polcyn Naren LBanik Azizul Haque | 2023 | Neural Regeneration Research2023，18，7： | 3 |
| 4 | Implications of enolase in the RANKL-mediated osteoclast activity following spinal cord injury显示文摘Spinal Cord Injury(SCI)is a debilitating condition characterized by damage to the spinal cord,resulting in loss of function,mobility,and sensation.Although increasingly prevalent in the US,no FDA-approved therapy exists due to the unfortunate complexity of the condition,and the difficulties of SCI may be furthered by the development of SCI-related complications,such as osteoporosis.SCI demonstrates two crucial stages for consideration:the primary stage and the secondary stage.While the primary stage is suggested to be immediate and irreversible,the secondary stage is proposed as a promising window of opportunity for therapeutic intervention.Enolase,a metabolic enzyme upregulated after SCI,performs non-glycolytic functions,promoting inflammatory events via extracellular degradative actions and increased production of inflammatory cytokines and chemokines.Neuron-specific enolase(NSE)serves as a biomarker of functional damage to neurons following SCI,and the inhibition of NSE has been demonstrated to reduce signs of secondary injury of SCI and to ameliorate dysfunction.This Viewpoint article involves enolase activation in the regulation of RANK-RANKL pathway and summarizes succinctly the mechanisms influencing osteoclast-mediated resorption of bone in SCI.Our laboratory proposes that inhibition of enolase activation may reduce SCI-induced inflammatory response and decrease osteoclast activity,limiting the chances of skeletal tissue loss in SCI. | RAMSHA SHAMS NAREN LBANIK AZIZUL HAQUE | 2021 | BIOCELL2021，45，6： | 3 |
| 5 | Clemastine in remyelination and protection of neurons and skeletal muscle after spinal cord injury显示文摘Spinal cord injuries affect nearly five to ten individuals per million every year. Spinal cord injury causes damage to the nerves, muscles, and the tissue surrounding the spinal cord. Depending on the severity, spinal injuries are linked to degeneration of axons and myelin, resulting in neuronal impairment and skeletal muscle weakness and atrophy. The protection of neurons and promotion of myelin regeneration during spinal cord injury is important for recovery of function following spinal cord injury. Current treatments have little to no effect on spinal cord injury and neurogenic muscle loss. Clemastine, an Food and Drug Administration-approved antihistamine drug, reduces inflammation, protects cells, promotes remyelination, and preserves myelin integrity. Recent clinical evidence suggests that clemastine can decrease the loss of axons after spinal cord injury, stimulating the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes that are capable of myelination. While clemastine can aid not only in the remyelination and preservation of myelin sheath integrity, it also protects neurons. However, its role in neurogenic muscle loss remains unclear. This review discusses the pathophysiology of spinal cord injury, and the role of clemastine in the protection of neurons, myelin, and axons as well as attenuation of skeletal muscle loss following spinal cord injury. | Ali Myatich Azizul Haque Christopher Sole Naren L.Banik | 2023 | Neural Regeneration Research2023，18，5： | 2 |
| 6 | The development of compressive strength of ground granulated blast furnace slag-palm oil fuel ash-fly ash based geopolymer mortar 显示文摘 | Azizul Islam U Johnson Alengaram Mohd Zamin Jumaat IftekhairIbnul Bashar | 2014 | Materials and Design2014，56，： | 1 |
| 7 | Chalcone and prenylated fla-vanones from MiUetia ovalifolia seeds显示文摘 | Rajinder KG MK Furano | 1980 | Phytochemistry1980，19，7： | 1 |
| 8 | Inventory Management Systems with Hazardous Items of Two-Parameter Exponential Distribution显示文摘 | AZIZUL B ANTON A K | 2009 | Journal of Social Sciences2009，5，3： | 1 |
| 9 | Media pressures and corporate disclosure of social responsibility performance information: a study of two global clothing and sports retail companies 显示文摘 | MUHAMMAD AZIZUL ISLAM CRAIG DEEGAN | 2010 | Accounting and Business Research2010，，2： | 1 |
| 10 | An Overview on the Time Delay Estimate in Active and Passive Systems for Target Localization显示文摘 | Azizul H Quazi | 1981 | IEEE Transations on Acoustics Speech and Signal Processing1981，29，3： | 1 |
| 11 | A stochastic frontier model on measuing online bank deposits efficiency显示文摘 | Azizul B Anton A K | 2010 | African Journal of Business Management2010，，4： | 1 |
| 12 | Apoptosis in Toxoplasma gondii activated T cells: The role of IFNγ in enhanced alteration of Bcl-2 expression and mitochondrial membrane potential显示文摘 | Sakhina Begum-Haque Azizul Haque Lloyd H. Kasper | 2009 | Microbial Pathogenesis2009，，5： | 1 |
| 13 | An Overview on the Time Delay Estimate in Active and Passive System for Target Localization 显示文摘 | Quazi Azizul H | 1981 | IEEE Transaction on Acoustic Speech and Signal Processing1981，29，3： | 1 |
| 14 | Effect of mild alkali pretreatment on structural changes of reed (Phragmites communis Trinius) straw 显示文摘 | Dhirendra Nath Barman Md Azizul Haque Tae Ho Kang | 2014 | Environmental Technology2014，35，2： | 1 |
| 15 | Neurological nmnifestations of Puffer fish poisoning and it' s outcome: study of 83 cases显示文摘 | AZIZUL HAQUE M TARIKUL ISLAM Q RAZZAK M A | 2008 | Teach Assoc J2008，21，2： | 1 |
| 16 | Generalized Normalized Euclidean Distance Based Fuzzy Soft Set Similarity for Data Classification显示文摘Classification is one of the data mining processes used to predict predetermined target classes with data learning accurately.This study discusses data classification using a fuzzy soft set method to predict target classes accurately.This study aims to form a data classification algorithm using the fuzzy soft set method.In this study,the fuzzy soft set was calculated based on the normalized Hamming distance.Each parameter in this method is mapped to a power set from a subset of the fuzzy set using a fuzzy approximation function.In the classification step,a generalized normalized Euclidean distance is used to determine the similarity between two sets of fuzzy soft sets.The experiments used the University of California(UCI)Machine Learning dataset to assess the accuracy of the proposed data classification method.The dataset samples were divided into training(75%of samples)and test(25%of samples)sets.Experiments were performed in MATLAB R2010a software.The experiments showed that:(1)The fastest sequence is matching function,distance measure,similarity,normalized Euclidean distance,(2)the proposed approach can improve accuracy and recall by up to 10.3436%and 6.9723%,respectively,compared with baseline techniques.Hence,the fuzzy soft set method is appropriate for classifying data. | Rahmat Hidayat Iwan Tri Riyadi Yanto Azizul Azhar Ramli Mohd Farhan Md.Fudzee Ansari Saleh Ahmar | 2021 | Computer Systems Science & Engineering2021，38，7： | 0 |
| 17 | Hyperuricemia Prediction Using Photoplethysmogram and Arteriograph显示文摘Hyperuricemia is an alarming issue that contributes to cardiovascular disease.Uric acid(UA)level was proven to be related to pulse wave velocity,a marker of arterial stiffness.A hyperuricemia prediction method utilizing photoplethysmogram(PPG)and arteriograph by using machine learning(ML)is proposed.From the literature search,there is no available papers found that relates PPG with UA level even though PPG is highly associated with vessel condition.The five phases in this research are data collection,signal preprocessing including denoising and signal quality indexes,features extraction for PPG and SDPPG waveform,statistical analysis for feature selection and classification of UA levels using ML.Adding PPG to the current arteriograph able to reduce cost and increase the prediction performance.PPG and arteriograph data were measured from 113 subjects,and 226 sets of data were collected from the left and right hands of the subjects.The performance of four types of ML,namely,artificial neural network(ANN),linear discriminant analysis(LDA),k-nearest neighbor(kNN),and support vector machine(SVM)in predicting hyperuricemia was compared.From the total of 98 features extracted,16 features of which showed statistical significance for hyper and normouricemia.ANN gives the best performance compared to the other three ML techniques with 91.67%,95.45%,and 94.12%for sensitivity,specificity,and accuracy,respectively.Features from PPG and arteriograph able to be used to predict hyperuricemia accurately and noninvasively.This study is the first to find the relationship of PPG with hyperuricemia.It shows a significant relation between PPG signals and arteriograph data toward the UA level.The proposed method of UA prediction shows its potential for noninvasive preliminary assessment. | Hafifah Ab Hamid Nazrul Anuar Nayan Mohd Zubir Suboh Nurin Izzati Mohamad Azizul Mohamad Nazhan Mohd Nizar Amilia Aminuddin Mohd Shahrir Mohamed Said Saharuddin Ahmad | 2022 | Computers, Materials & Continua2022，，4： | 0 |
| 18 | Mean Opinion Score Estimation for Mobile Broadband Networks Using Bayesian Networks显示文摘Mobile broadband(MBB)networks are expanding rapidly to deliver higher data speeds.The fifth-generation cellular network promises enhanced-MBB with high-speed data rates,low power connectivity,and ultralow latency video streaming.However,existing cellular networks are unable to perform well due to high latency and low bandwidth,which degrades the performance of various applications.As a result,monitoring and evaluation of the performance of these network-supported services is critical.Mobile network providers optimize and monitor their network performance to ensure the highest quality of service to their end-users.This paper proposes a Bayesian model to estimate the minimum opinion score(MOS)of video streaming services for any particular cellular network.The MOS is the most commonly used metric to assess the quality of experience.The proposed Bayesian model consists of several input data,namely,round-trip time,stalling load,and bite rates.It was examined and evaluated using several test data sizes with various performance metrics.Simulation results show the proposed Bayesian network achieved higher accuracy overall test data sizes than a neural network.The proposed Bayesian network obtained a remarkable overall accuracy of 90.36%and outperformed the neural network. | Ayman A.El-Saleh Abdulraqeb Alhammadi Ibraheem Shayea Azizul Azizan Wan Haslina Hassan | 2022 | Computers, Materials & Continua2022，，9： | 0 |
| 19 | English Language Needs of Non-native Foreign Students显示文摘 | Shahrier Pawanchik Anton Abdulbasah Kamil Mohd Faiz Hilmi Md. Azizul Baten | 2011 | Sino-US English Teaching2011，8，8： | 0 |
| 20 | The coastal medicinal plant Vitex rotundifolia: a mini-review on its bioactive compounds and pharmacological activity显示文摘Humans have long used natural remedies like plants and herbs to treat disease.Furthermore,research has been ongoing to find alternative pharmaceutical drugs based on traditionally used plants,as natural products show fewer side effects compared to synthetic drugs.Medicinal plants have long been targeted in drug development due to their bioactive compounds like alkaloids,flavonoids,and terpenoids.This is not only the case for terrestrial plants,but marine environments also provide a larger diversity of flora and fauna with medicinal bioactive compounds.Vitex rotundifolia,also known as Beach Vitex,is a coastal plant that has been traditionally used to treat a variety of diseases including premenstrual syndrome,headaches,migraines,colds,and eye pain.There have been many review papers on V.rotundifolia,emphasizing its taxonomy,distribution,and biological activity.Our current mini-review not only summarizes the pharmacology and bioactivity of V.rotundifolia,but it also provides new information on the main bioactive compounds of V.rotundifolia such as flavonoids,phenolic acid,and terpenes and their current pharmacological activity in vitro and in vivo research.This information can be useful for developing new pharmaceutical and nutraceutical agents to treat and manage disease. | Nurul Husna Azizul Wan Amir Nizam Wan Ahmad Nurul Laili Rosli Muhammad Aniq Hamzah Mohd Azmi Choo En Liang Noor Wini Mazlan Suvik Assaw | 2021 | Traditional Medicine Research2021，6，2： | 0 |
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