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| 1 | Clemastine in remyelination and protection of neurons and skeletal muscle after spinal cord injury显示文摘Spinal cord injuries affect nearly five to ten individuals per million every year. Spinal cord injury causes damage to the nerves, muscles, and the tissue surrounding the spinal cord. Depending on the severity, spinal injuries are linked to degeneration of axons and myelin, resulting in neuronal impairment and skeletal muscle weakness and atrophy. The protection of neurons and promotion of myelin regeneration during spinal cord injury is important for recovery of function following spinal cord injury. Current treatments have little to no effect on spinal cord injury and neurogenic muscle loss. Clemastine, an Food and Drug Administration-approved antihistamine drug, reduces inflammation, protects cells, promotes remyelination, and preserves myelin integrity. Recent clinical evidence suggests that clemastine can decrease the loss of axons after spinal cord injury, stimulating the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes that are capable of myelination. While clemastine can aid not only in the remyelination and preservation of myelin sheath integrity, it also protects neurons. However, its role in neurogenic muscle loss remains unclear. This review discusses the pathophysiology of spinal cord injury, and the role of clemastine in the protection of neurons, myelin, and axons as well as attenuation of skeletal muscle loss following spinal cord injury. | Ali Myatich Azizul Haque Christopher Sole Naren L.Banik | 2023 | Neural Regeneration Research2023，18，5： | 2 |
| 2 | A discussion of the molecular mechanisms of moisture transport in organic coating显示文摘 | L Christopher Soles Albert Fee | 2000 | Polym Sci Polym Phys ed2000，38，： | 1 |
| 3 | Effect of imtial resist thickness on residual layer thickness of nanoimprinted structures显示文摘 | Hyun Wook Ro Christopher L Soles | 2002 | J Vac Sci Technol B2002，23，6： | 1 |
| 4 | Contribution of the nanvoid structune to the kinetics of moisture transport in epoxy resins 显示文摘 | Christopher L Soles Femando T Chang David W Gidley | 2000 | Journal of Polymer Science Part B:Polymer Physics2000，38，： | 1 |
| 5 | Discussion of the molecular mechanisms of moisture transport in epoxy resins 显示文摘 | Soles Christopher L Yee Albert F | 2000 | Journal of Polymer Science Part B: Polymer Physics2000，38，5： | 1 |
| 6 | The WAK-like protein RFO1 acts as a sensor of the pectin methylation status in Arabidopsis cell walls to modulate root growth and defense显示文摘Most organisms adjust their development according to the environmental conditions.For the majority,this implies the sensing of alterations to cell walls caused by different cues.Despite the relevance of this process,few molecular players involved in cell wall sensing are known and characterized.Here,we show that the wall-associated kinase-like protein RESISTANCE TO FUSARIUM OXYSPORUM 1(RFO1)is required for plant growth and early defense against Fusarium oxysporum and functions by sensing changes in the pectin methylation levels in the cell wall.The RFO1 dwell time at the plasma membrane is affected by the pectin methylation status at the cell wall,regulating MITOGEN-ACTIVATED PROTEIN KINASE and gene expression.We show that the extracellular domain of RFO1 binds de-methylated pectin in vitro,whose distribution in the cell wall is altered during F.oxysporum infection.Further analyses also indicate that RFO1 is required for the BR-dependent plant growth alteration in response to inhibition of pectin de-methyl-esterase activity at the cell wall.Collectively,our work demonstrates that RFO1 is a sensor of the pectin methylation status that plays a unique dual role in plant growth and defense against vascular pathogens. | Apolonio I.Huerta Gloria Sancho-Andre´s Juan Carlos Montesinos Javier Silva-Navas Sole`ne Bassard Corinne Pau-Roblot Christopher Kesten Rudolf Schlechter Susanne Dora Temurkhan Ayupov Je´rome Pelloux^ Julia Santiago Clara Sa´nchez-Rodrı´guez | 2023 | Molecular Plant2023，16，5： | 0 |
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