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| 1 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 2 | Mimicking unfolding motion of a beetle hind wing显示文摘This paper presents an experimental research aiming to realize an artificial hind wing that can mimic the wing unfolding motion of Allomyrina dichotoma, an insect in coleopteran order. Based on the understanding of working principles of beetle wing folding/unfolding mechanisms, the hind wing unfolding motion is mimicked by a combination of creative ideas and state-of-art artificial muscle actuator. In this work, we devise two types of artificial wings and the successfully demonstrate that they can be unfolded by actuation of shape memory alloy wires to provide actuation force at the wing base and along the leading edge vein. The folding/unfolding mechanisms may provide an insight for portable nano/micro air vehicles with morphing wings. | MUHAMMAD Azhar PARK Hoon C HWANG Do Y BYUN Doyoung GOO Nam S | 2009 | Chinese Science Bulletin2009，54，14： | 3 |
| 3 | Inactivation of endothelial derived relaxing factor by oxidized lipoproteins显示文摘 | Chin JH Azhar S Hoffman BB | 1992 | J Clin Invest1992，89，1： | 1 |
| 4 | Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells显示文摘 | Cao L Leers-Sucheta S Azhar S | 2004 | J Steroid Biochem Mol Biol2004，88，1： | 1 |
| 5 | Periodontal status and IOTN interve- ntions among young hemophiliacs 显示文摘 | Azhar S Yazdanie N Muhammad N | 2006 | Haemophilia2006，12，4： | 1 |
| 6 | Poster 70: Very early use of intratheeal ba- clofen in a stroke patient is safe and eficacious:a ease report 显示文摘 | Azhar S | 2006 | Arch Phys Med Rehabil2006，87，10： | 1 |
| 7 | Inactivation of endothelial derived relaxing factor by oxidized lipoproteins 显示文摘 | Chin JH Azhar S Hoffman BB | 1982 | J Clin Invest1982，89，1： | 1 |
| 8 | Comparison of class B scavenger receptors, CD36 and scavenger receptor B I ( SR-B I ), shows that both receptors mediate high density lipoprotein-cholesteryl ester selective uptake but SR-B I exhibits a unique enhancement of cholesteryl ester uptake显示文摘 | Connelly M A Klein S M Azhar S | 1999 | J Biol Chem1999，274，1： | 1 |
| 9 | Prevention of insulin resistance by environmental manipulation as young rats mature显示文摘 | SANTOS R F AZHAR S MONDON C | 1989 | Horm Metabol Res1989，21，： | 1 |
| 10 | Building information modeling (BIM): trends, benefits, risks, and challenges for the AEC industry 显示文摘 | Azhar S | 2011 | Leadership and Management in Engineering2011，，3： | 1 |
| 11 | Down-regulation of steroidogenic acute regulatory (StAR) protein in rat Leydig cells: implications for regulation of testosterone production during aging显示文摘 | Leers-Sucheta S Stocco DM Azhar S | 1999 | Mech Ageing Dev1999，107，2： | 1 |
| 12 | Clinical features and out- come of sporadic colorectal carcinoma in young patients: a cross sectional analysis form a developing country显示文摘 | Zahir MN Azhar EM Rafiq S et a l | 2014 | ISRN 0ncol2014，20，14： | 1 |
| 13 | Insulin resistance in older rats显示文摘 | NARIMIYA M AZHAR S DOLKAS CB | 1984 | 246(5Pt 1):E397-4041984，246，51： | 1 |
| 14 | Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: relative contribution of scavenger receptor class B (type I) and adenosine 5'-triphosphate-binding cassette (type A1) transporter in high-density lipoprotein-cholesterol transport and androgen synthesis显示文摘 | Wu Q Sucheta S Azhar S | 2003 | Endocrinol2003，144，： | 1 |
| 15 | Osteoporosis: prevention and impli- cations for social work practice and practice and policy 显示文摘 | Lawrence S A Azhar A | 2010 | Soc Work Public Health2010，25，9： | 1 |
| 16 | Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages 显示文摘 | Atabai K Jame S Azhar N | 2009 | J Clin Invest2009，119，12： | 1 |
| 17 | Impact of aging on steroid hormone biosynthesis and secretion显示文摘 | Zaidi SK Shen WJ Azhar S | | 0，，： | 1 |
| 18 | Comparison of the strength and durability performance of normal and high-strength pozzolanic concretes at elevated temper- atures 显示文摘 | Pooh C S Azhar S Anson M | 2001 | Cement and Concrete Research2001，31，9： | 1 |
| 19 | Comparison of the strength and durability performance of normal and highstrength pozzolanic concretes at elevated temperatures显示文摘 | POON C S AZHAR S ANSON M | 2011 | Cement and Concrete Research2011，31，9： | 1 |
| 20 | A new noninvasive technique for imaging atherosclerotic plaque in the aortic arch of stroke patients by transcutaneous real-time B-mode ultrasonography: an initial report显示文摘 | Weinberger J Azhar S Danisi F | 1998 | Stroke1998，29，： | 1 |
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