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| 1 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 2 | Bioimpedance phase angle predicts mus- cle function, quality of Life and clinical outcome in maintenance hemodialysis pa- tients显示文摘 | Beberashvili I Azar A Sinuani I | 2014 | European Journal of Clinical Nu- trition2014，68，6： | 1 |
| 3 | Mesangial immune injury, hypertension and progression glomerular damage in Dahl rats 显示文摘 | Raij I Azar S Keane W | 1984 | Kidney Int1984，26，： | 1 |
| 4 | Low serum concentration of obestatin as a predictor of mortality in maintenance hemodialysis patients显示文摘 | Beberashvili I Sinuani I Azar A | 2013 | Biomed Res Int2013，，79： | 1 |
| 5 | Comparison analysis of nutri- tional scores for serial monitoring of nutritional status inhemodialysis patients显示文摘 | Beberashvili I Azar A Sinuani I | 2013 | Clin J Am Soc Nephrol2013，8，3： | 1 |
| 6 | Mesangial immune injury, hypertension and progression glomerular damage in Dahl rats显示文摘 | Azar S Keane W | 1984 | Kidney Int1984，26，： | 1 |
| 7 | Mesangial immune injury, hypertension and progression glomerular damage in Dahl rats 显示文摘 | Raij I Azar S Keane W | 1984 | Kidney Int1984，26，： | 1 |
| 8 | A random forest classifier for lymph diseases 显示文摘 | Azar A T Elshazly H I Hassanien A E | 2014 | Computer Methods and Programs in Biomedicine2014，113，2： | 1 |
| 9 | Mesangial immune injury, hypertension and progression glomerular damage in Dahl rats显示文摘 | RAIJ I AZAR S KEANE W | 1984 | Kidney Int1984，26，： | 1 |
| 10 | Alteration in plasmatransforming growth factor beta in normoalbuinuric type 1and type 2 diabetic patient显示文摘 | Azar ST Salti I Zantout MS | 2002 | Clin Endocrinol Metab2002，85，12： | 1 |
| 11 | Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins 显示文摘 | David A Mabjeesh N Azar I | 2002 | J Biol Chem2002，277，18： | 1 |
| 12 | Successful treatment of parathyroid cyst using ethanol sclerotherapy显示文摘 | Akel M Salti I Azar ST | 1999 | Am J Med Sci1999，317，1： | 1 |
| 13 | Development of a new cuttings- transport model for high-angle wellbores including horizontal wells 显示文摘 | Larsen T I Pilehvari A A Azar J J | 1997 | SPE Drilling & Completion1997，12，2： | 1 |
| 14 | Development of a new cuttings transport models for high angle well bores including horizontal wells显示文摘 | LARSEN T I PILEHVARI A A AZAR J J | 1993 | SPE 258721993，，： | 1 |
| 15 | Success of monovision in presbyopes:review of the literature and potential applications to refractive surgery显示文摘 | Jain S Arora I Azar DT | 1996 | Surv Ophthalmol1996，40，6： | 1 |
| 16 | A random forest classifier for lymph diseases显示文摘 | AZAR A T ELSHAZLY H I HASSANIEN A E | 2014 | Computer Methods and Programs in Biomedicine2014，113，2： | 1 |
| 17 | Objective Score of Nutri- tion on Dialysis (OSND) as an alternative for the malnutrition-in- flammation score in assessment of nutritional risk of haemodialysis pa- tients 显示文摘 | Beberashvili L Azar A Sinuani I | 2010 | Nephrol Dial Transplant2010，25，8： | 1 |
| 18 | Objective Score of Nutrition on Dialysis(OSND)as an altemative for the malnutrition-in-flammation score in assessment of mutritional risk of hemodialysis patients显示文摘 | BEBERASHVILI L AZAR A SINUANI I | 2010 | Nephrol Dial Transplant2010，25，5： | 1 |
| 19 | Management of traumatic cataracts (Article)显示文摘 | Mian S I Azar D T Colby K | 2002 | International Ophthalmology Clinics2002，42，1： | 1 |
| 20 | Increased basal nitric oxide amplifies the association of inflammation with all-cause and cardiovascular mortality in prevalent hemodialysis patients 显示文摘 | Beberashyili I Sinuani I Azar A | 2013 | Int Urol Nephrol2013，45，6： | 1 |
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