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| 1 | Tax competition and FDI:the special case of developing countries显示文摘 | Azémar C Delios A | 2008 | Journal of the Japanese and International Economies2008，22，1： | 1 |
| 2 | Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway:Providing understanding of the complex mechanisms of chemoresistance显示文摘Colorectal cancer(CRC)continues to be one of the main causes of death from cancer because patients progress unfavorably due to resistance to current therapies.Dysregulation of the Wnt/β-catenin pathway plays a fundamental role in the genesis and progression of several types of cancer,including CRC.In many subtypes of CRC,hyperactivation of theβ-catenin pathway is associated with mutations of the adenomatous polyposis coli gene.However,it can also be associated with other causes.In recent years,studies of the tumor microenvironment(TME)have demonstrated its importance in the development and progression of CRC.In this tumor nest,several cell types,structures,and biomolecules interact with neoplastic cells to pave the way for the spread of the disease.Cross-communications between tumor cells and the TME are then established primarily through paracrine factors,which trigger the activation of numerous signaling pathways.Crucial advances in the field of oncology have been made in the last decade.This Minireview aims to actualize what is known about the central role of the Wnt/β-catenin pathway in CRC chemoresistance and aggressiveness,focusing on crosscommunication between CRC cells and the TME.Through this analysis,our main objective was to increase the understanding of this complex disease considering a more global context.Since many treatments for advanced CRC fail due to mechanisms involving chemoresistance,the data here exposed and analyzed are of great interest for the development of novel and effective therapies. | María Belén Novoa Díaz María Julia Martín Claudia Gentili | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 3 | Bladder recurrence after surgery for upper urinary tract urothelial cell carcinoma:frequency,risk factors,and surveillance显示文摘 | Azémar MD Comperat E Richard F | 2011 | Urol Oncol2011，29，： | 1 |
| 4 | Do tax sparing agreements contribute to the attraction of FDI in developing countries?显示文摘 | Céline Azémar Rodolphe Desbordes Jean-Louis Mucchielli | 2007 | International Tax and Public Finance2007，，5： | 1 |
| 5 | Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage显示文摘 | José María Gutiérrez Alexandra Rucavado Teresa Escalante Cecilia Díaz | 2005 | Toxicon2005，，8： | 1 |
| 6 | How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells显示文摘Colorectal cancer(CRC)remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant characteristics.It is well established that the appearance of distal metastasis in CRC patients is the cause of a poor prognosis and treatment failure.Nevertheless,in the last decades,CRC aggressiveness and progression have been attributed to a specific cell population called CRC stem cells(CCSC)with features like tumor initiation capacity,self-renewal capacity,and acquired multidrug resistance.Emerging data highlight the concept of this cell subtype as a plastic entity that has a dynamic status and can be originated from different types of cells through genetic and epigenetic changes.These alterations are modulated by complex and dynamic crosstalk with environmental factors by paracrine signaling.It is known that in the tumor niche,different cell types,structures,and biomolecules coexist and interact with cancer cells favoring cancer growth and development.Together,these components constitute the tumor microenvironment(TME).Most recently,researchers have also deepened the influence of the complex variety of microorganisms that inhabit the intestinal mucosa,collectively known as gut microbiota,on CRC.Both TME and microorganisms participate in inflammatory processes that can drive the initiation and evolution of CRC.Since in the last decade,crucial advances have been made concerning to the synergistic interaction among the TME and gut microorganisms that condition the identity of CCSC,the data exposed in this review could provide valuable insights into the biology of CRC and the development of new targeted therapies. | María Belén Novoa Díaz Pedro Carriere Claudia Gentili | 2023 | World Journal of Stem Cells2023，15，5： | 0 |
| 7 | A rare pigmented keratitis caused by Aspergillus fumigatus显示文摘Dear Sir,I am Mauricio Vélez,from the Department of Ophthalmology,Cornea Service Director,Universidad Pontificia Bolivariana in Medellín,Colombia.Below,I would like to share an interesting case I managed recently,which I’ve entitled'A rare pigmented keratitis caused by Aspergillus fumigatus'.Fungi are a relatively uncommon cause of microbial | Mauricio Vélez Kepa Balparda Ana María Díaz | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 0 |
| 8 | Microenvironment and endocrine resistance in breast cancer:Friend or foe?显示文摘Breast cancer affects one in eight women around the world. Seventy five percent of these patients have tumors that are estrogen receptor positive and as a consequence receive endocrine therapy. However,about one third eventually develop resistance and cancer reappears. In the last decade our vision of cancer has evolved to consider it more of a tissuerelated disease than a cell-centered one. This editorial argues that we are only starting to understand the role the tumor microenvironment plays in therapy resistance in breast cancer. The development of new therapeutic strategies that target the microenvironment will come when we clearly understand this extremely complicated scenario. As such,and as a scientific community,we have extremely challenging work ahead. We share our views regarding these matters. | Sol Recouvreux Rocío Sampayo María Inés Díaz Bessone Marina Simian | 2015 | World Journal of Clinical Oncology2015，6，6： | 1 |
| 9 | Glutathione depleting drugs, antioxidants and intestinal calcium absorption显示文摘Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. | Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni | 2018 | World Journal of Gastroenterology2018，24，44： | 5 |
| 10 | Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review显示文摘Drug-induced liver injury encompasses a spectrum of diseases ranging from mild biochemical abnormalities to acute liver failure; example of this scenery is hepatotoxicity caused by the first-line antituberculous drugs isoniazid, rifampin and pyrazinamide, which are basic for treatment of drug-sensible and drug-resistant tuberculosis. In the search for pharmacological alternatives to prevent liver damage, antitubercular drugs have been the subject of numerous studies and published reviews, a great majority of them carried out by Asian countries. At the same time, hepatoprotectors from plant source are now emerging as a possible alternative to counteract the toxic effects of these therapeutic agents. The present review aims to highlight the most recent studies on the subject, based information published in scientific databases such as Scopus and Pub Med. | María Adelina Jiménez-Arellanes Gabriel Alfonso Gutiérrez-Rebolledo Mariana Meckes-Fischer Rosalba León-Díaz | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 3 |
| 11 | Is leptin related to systemic inflammatory response in acute pancreatitis?显示文摘瞄准:在尖锐胰腺炎评估在 leptin 和全身的发炎之间的关系。方法:有尖锐胰腺炎的连续病人被包括。身体集体索引和浆液样品在承认被获得。Leptin, TNF-alpha, IL-6, -8 和 -10 层次被 ELISA 决定。严厉根据亚特兰大标准被定义。结果:52 (29 女性) 病人们被学习。全面身体团索引在温和、严重的盒子之间是类似的,尽管有严重胰腺炎的女人有更低的身体团索引(P = 0.04 ) 并且男人证明更高的身体质量索引(P = 0.05 ) 。没有差别关于胰腺炎的严厉在 leptin 层次被发现,但是高水平趋于与增加的身体团索引和严重胰腺炎出现在男病人(P = 0.1 ) 。多,变量分析显示出的 A 在 leptin 层次和严厉之间的没有协会。与严厉联系的最强壮的 cytokine 是 IL-6。有另一 cytokines 的 leptin 的关联仅仅为 IL-8 显示出一个趋势(P = 0.058 ) 。结论:高身体团索引仅仅在男性与严厉被联系,它可能与机器人脂肪分发有关。浆液 leptin 似乎不在男性与严重结果在尖锐胰腺炎和它的协会在全身的煽动性的反应上起一个作用可能代表增加的脂肪过多的一个标记。 | Andrés Duarte-Rojo Ana Lezama-Barreda María Teresa Ramírez-Iglesias Mario Peláez-Luna Guillermo Robles-Díaz | 2006 | World Journal of Gastroenterology2006，12，27： | 2 |
| 12 | Phenotypic and molecular identification of yeast species associated with Spanish blue-veined Cabrales cheese显示文摘 | Pablo álvarez-Martín Ana Belén Flórez Teresa María López-Díaz Baltasar Mayo | 2007 | International Dairy Journal2007，，8： | 1 |
| 13 | Photooxidative stress activates a complex multigenic response integrating the phenylpropanoid pathway and ethylene,leading to lignin accumulation in apple(Malus domestica Borkh.)fruit显示文摘Photooxidative stress,when combined with elevated temperatures,triggers various defense mechanisms leading to physiological,biochemical,and morphological changes in fruit tissue.Furthermore,during sun damage,apple fruit undergo textural changes characterized by high flesh firmness compared to unexposed fruit.Fuji and Royal Gala apples were suddenly exposed to sunlight on the tree and then sampled for up to 29 days.Cell wall components and lignin biosynthetic pathway analyses were carried out on the fruit tissue.At harvest,Fuji apples with different sun exposure levels,such as exposed to direct sunlight(Exp),shaded(Non-Exp),and with severe sun damage(Sev),were also characterized.In fruit suddenly exposed to sunlight,the expression levels of phenylpropanoid-related genes,phenylalanine ammonia lyase(MdPAL),chalcone synthase(MdCHS),and flavanone-3-hydroxylase(MdF3H),were upregulated in the skin and flesh of Exp and Sev.Exposure had little effect on the lignin-related genes caffeic acid Omethyltransferase 1(MdCOMT1)and cinnamyl alcohol dehydrogenase(MdCAD)in the skin;however,the expression of these genes was highly induced in the flesh of Exp and Sev in both cultivars.Lignin deposition increased significantly in skin with sun injury(Sev);in flesh,this increase occurred late during the stress treatment.Additionally,the ethylene biosynthesis genes 1-aminocyclopropane-1-carboxylate synthase(MdACS)and 1-aminocyclopropane-1-carboxylate oxidase(MdACO)were highly expressed in the skin and flesh tissues but were more upregulated in Sev than in Exp during the time-course experiment,which paralleled the induction of the phenylpropanoid pathway and lignin accumulation.At harvest,flesh from Sev fruit exhibited higher firmness than that from Non-Exp and Exp fruit,although no differences were observed in the alcohol-insoluble residues(AIR)among groups.The fractionation of cell wall polymers revealed an increase in the uronic acid contents of the water-soluble pectin fraction(WSF)in Exp and Sev tissues compared to Non-Exp tissues,while the other pectin-rich fractions,that is,CDTA-soluble(CSF)and Na2CO3-soluble(NSF),were increased only in Sev.The amount of hemicellulose and cellulose did not differ among fruit conditions.These findings suggest that increases in the flesh firmness of apples can be promoted by photooxidative stress,which is associated with the induction of lignin accumulation in the skin and flesh of stressed fruit,with the involvement of stress phytohormones such as ethylene. | Carolina A.Torres Constanza Azocar Patricio Ramos Ricardo Pérez-Díaz Gloria Sepulveda María A.Moya-León | 2020 | Horticulture Research2020，7，1： | 1 |
| 14 | C1A cysteine‐proteases and their inhibitors in plants显示文摘 | ManuelMartínez InésCambra PabloGonzález‐Melendi María E.Santamaría IsabelDíaz | 2012 | Physiologia Plantarum2012，，1： | 1 |
| 15 | Response of alfalfa (Medicago sativa L.) to single and mixed inoculation with phosphate-solubilizing bacteria and Sinorhizobium meliloti显示文摘 | Lorena Belén Gui?azú Javier Alberto Andrés María Florencia Del Papa Mariano Pistorio Susana Beatriz Rosas | 2010 | Biology and Fertility of Soils2010，，2： | 1 |
| 16 | Evaluation of the visual function in obstructive sleep apnea syndrome patients and normal-tension glaucoma by means of the multifocal visual evoked potentials显示文摘 | Esperanza Gutiérrez-Díaz Consuelo Pérez-Rico María Josefa Atauri Enrique Mencía-Gutiérrez Román Blanco | 2012 | Graefe’s Archive for Clinical and Experimental Ophthalmology2012，，11： | 1 |
| 17 | Allelopathic agents from aquatic ecosystems: potential biopesticides models显示文摘 | Francisco A. Macías José L. G. Galindo María D. García-Díaz Juan C. G. Galindo | 2008 | Phytochemistry Reviews2008，，1： | 1 |
| 18 | Chiral Amino Diol Derivatives as New Modular Organocatalysts for the Enantioselective α‐Chlorination of Cyclic β‐Keto Esters显示文摘 | PabloEtayo RamónBadorrey María D.Díaz‐de‐Villegas José A.Gálvez | 2010 | Adv Synth Catal2010，，18： | 1 |
| 19 | New role of the human equilibrative nucleoside transporter 1 (hENT1) in Epithelial‐to‐mesenchymal transition in renal tubular cells显示文摘 | ElenaGuillén‐Gómez ItziarPinilla‐Macua SandraPérez‐Torras Doo‐SupChoi YolandaArce José A.Ballarín Mar?alPastor‐Anglada Montserrat M.Díaz‐Encarnación | 2012 | J Cell Physiol2012，，4： | 1 |
| 20 | 墨西哥瓦瓦州州东北部橡树商品材材积核算系统(英文)显示文摘比较了Kozak(1988),Bi(2000)和Fang等(2000)的削度模型,形成了橡树商品材材积核算系统。在所研究的不同树龄、不同密度的松树.橡树混交林内,采集了298株橡树削度数据。结果表明,Fang等(2000)建立的可兼容分段模型可以很好地描述实验数据,可用于估测树木在指定树高的直径、树高.指定直径比、商品材材积量和总体积。本研究建立的公式可作为该研究区内森林调查的基本工具,简便、易于操作。统计分析结果表明,尽管本研究所建立的公式具有局地适应性,但仍可应用于其他区域。 | Marín POMPA-GARCíA José Javier CORRAL-RIVAS José Ciro HERNáNDEZ-DíAZ Juan Gabriel ALVAREZ-GONZáLEZ | 2009 | Journal of Forestry Research2009，20，4： | 1 |
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