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| 1 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 2 | A mathematical model of blast furnace reaction analysis based on the four fluid model显示文摘 | AUSTIN P R NOGAMI H YAGI J | 1997 | ISIJ International1997，37，8： | 1 |
| 3 | Resuscitation- induced pulmonary apoptosis and intracellular adhesion mole-cule-1 expression in rats are attenuated by the use of ketone Ringer's solution 显示文摘 | ALAM H B AUSTIN B KOUSTOVA E | 2001 | Am Coil Surg2001，193，： | 1 |
| 4 | Prediction of blast furnaceperformance with top gas recycling 显示文摘 | Austin P R Nogami H Yagi J | 1998 | ISIJ International1998，38，3： | 1 |
| 5 | Arabidopsis map kinase 4 negatively regulates systemic acquired resistance显示文摘 | Petersen M Brodersen P Naested H Andreasson E Lindhart U Johansen B Nielsen H B Lacy M Austin M J Parker J E | | 0，，： | 1 |
| 6 | A follow - up study of methods of contraception, sexual activity and rates of trichomonia-sis, candidiasis and bacterial vaginosis显示文摘 | Barbone F Austin H Louv WC | 1990 | Am J Obstet Gynecol1990，163，： | 1 |
| 7 | A mathematical model of four phase motion and heat transfer in the blast furnace显示文摘 | AUSTIN P R NOGAMI H YAGI J | 1997 | ISIJ International1997，37，5： | 1 |
| 8 | Haematology and neurology 显示文摘 | Austin S Cohen H Losseff L | 2007 | J Neurol Neurosurg Psychiatry2007，78，： | 1 |
| 9 | Characteristics of an immobilized lipase for the commercial synthesis of esters显示文摘 | MILLER C AUSTIN H POSORSKE L | 1988 | J Am Oil Chem Soc1988，65，： | 1 |
| 10 | A mathematical model for blast furnace reaction analysis based on the four fluid model显示文摘 | AUSTIN P R NOGAMI H YAGI J | 1997 | ISIJ International1997，37，8： | 1 |
| 11 | Social and commer-cial entrepreneurship : same,different,or both 显示文摘 | Austin J Stevenson H Skillem J | 2006 | Entrepreneurship Theory and Practice2006，30，1： | 1 |
| 12 | Demand-driven cooperative collection development: three case studies from the USA显示文摘 | H Austin Booth Kathleen O'Brien | 2011 | Interlending & Document Supply2011，39，3： | 1 |
| 13 | Correspondence be- tween environmental gradients and summer littoral fish assemblages in low salinity reaches of the Chesa- peake Bay, USA显示文摘 | WAGNER C M AUSTIN H M | 1999 | Marine Ecology Progress1999，177，3： | 1 |
| 14 | Therapy of lupus nephritis:controlled trail of prerdnisone and cytotoxic drugs显示文摘 | AUSTIN HA Ⅲ KLIPPEL J H BALOW J E | 1998 | N Engl J Meal1998，314，： | 1 |
| 15 | Computational investigation of scrap charging to the blast furnace显示文摘 | AUSTIN P R NOGAMI H YAGI J | 1998 | ISIJ International1998，38，7： | 1 |
| 16 | Diffues proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome显示文摘 | Austin H Muenz L Joyce K M | 1984 | Kidney lnt1984，25，4： | 1 |
| 17 | Organizing care forpa- tients with chronic illness显示文摘 | Wagner E H Austin B T Von Korf M | 1996 | Milbank Q1996，，74： | 1 |
| 18 | Guidelines for management of small pulmonary nodules detected on CT scans: A statement from the Fleischner Society 显示文摘 | MacMahon H Austin JH Gamsu G | 2005 | Radiology2005，237，2： | 1 |
| 19 | Analysis of Actual Blast Furnace Operations and Evaluation of Static Liquid Holdup Effects by the Four Fluid Model显示文摘 | Austin P R Nogami H Yagi J | 1998 | ISU International1998，38，3： | 1 |
| 20 | Effect of sulfate ions and associated cation type on the pore solution chemistry in chloride-contaminated plain and blended ce ments显示文摘 | Dehwah H A F Maslehuddin M Austin S A | 2003 | Cem Concr Compos2003，25，45： | 1 |
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