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| 1 | 巴西构造应力场的遗传有限单元法反演显示文摘基于观测的主应力方位资料,应用遗传有限单元法对巴西及邻区边界位移和板内力源进行了反演,确认了前人的研究结果:板块边界作用是控制区域应力场的主要因素,山脉和海岸地形造成的扩展力是控制应力场的一个重要因素.同时显示了板块在垂直载荷下的弯曲对局部水平应力场造成相当的影响.反演结果也表明,除了过去公认的东西向挤压作用外,巴西还受到相当明显的南北向构造作用.它的存在与最近GPS资料的分析是一致的.研究还表明遗传有限单元法是偏微分方程反演问题求解的一种有效方法. | 石耀霖 Marcelo Assumpcao | 2000 | 地球物理学报2000，43，2： | 14 |
| 2 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 3 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 4 | Insights into gastric neuroendocrine tumors burden显示文摘Type 1 gastric neuroendocrine tumors(g NETs)are usually small lesions,restricted to mucosal and sub-mucosal layers of corpus and fundus,with low aggressive behavior,for the majority of cases.Nevertheless,some cases present aggressive behavior.The increasing incidence of g NETs brings together a new relevant problem:how to identify potentially aggressive type 1 g NETs.The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases,allowing a tailored approach,since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors.Additionally,it is also important to try to find out explanations for increasing incidence,as well as to identify potential targets aiming to reach better control of this neoplasia.Here,we discuss potential pathways implicated in aggressive behavior,as well as new strategies to improve clinical management of these tumors. | Taíssa Maíra Thomaz Araújo Williams Fernandes Barra André Salim Khayat Paulo Pimentel de Assumpcao | 2017 | Chinese Journal of Cancer Research2017，29，2： | 7 |
| 5 | Hereditary gastric cancer:Three rules to reduce missed diagnoses显示文摘Gastric cancer remains one of the most lethal cancers.The incidence and mortality rates are quite similar.The main reason for the high mortality is diagnosis at advanced stages of disease,when treatment options are poor.One of the supposed strategies to overcome late-stage diagnosis is identifying people at high risk with the aim of establishing rigorous clinical control,including routine endoscopy and biopsies.Hereditary gastric cancer(HGC)syndromes,though representing a sizeable group to monitor for prevention or,at least,for early diagnosis,are apparently extremely rare.The low rate of HGC diagnosis might be related to the low rates of suspicion,insufficient familiarity about clinical diagnosis criteria,and the supposed conditional necessity of a molecular diagnosis.In this review,we will discuss simple measures to increase HGC diagnosis by applying three rules that might provide an opportunity for precision care to benefit the families affected by this disease. | Paula Assumpcao Taíssa Araújo André Khayat Geraldo Ishak Sidney Santos Williams Barra Joao Felipe Acioli Benedito Rossi Paulo Assumpcao | 2020 | World Journal of Gastroenterology2020，26，13： | 3 |
| 6 | Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer显示文摘 | Timothy M. Pawlik Ana L. Gleisner John L. Cameron Jordan M. Winter Lia Assumpcao Keith D. Lillemoe Christopher Wolfgang Ralph H. Hruban Richard D. Schulick Charles J. Yeo Michael A. Choti | 2007 | Surgery2007，，5： | 3 |
| 7 | Heart Valve Injury Induced by Mediastinum Radiotherapy in Cancer Treatment显示文摘 | Patricia Fraga Paiva Alice Assumpcao Soares Guilherme Sotto Maior do Valle Pinheiro Carolina Fraga Paiva Gisele Maria Campos Fabri Emanoel Guimaraes Paiva Carlos M. Campos Jose Fabfi Junior | 2018 | Journal of Pharmacy and Pharmacology2018，6，6： | 2 |
| 8 | Preoperative Assessment of Hepatocellular Carcinoma Tumor Grade Using Needle Biopsy: Implications for Transplant Eligibility显示文摘 | Timothy M. Pawlik Ana L. Gleisner Robert A. Anders Lia Assumpcao Warren Maley Michael A. Choti | 2007 | Annals of Surgery2007，，3： | 2 |
| 9 | Reliable gastric closure after natural orifice translumenal endoscopic surgery (NOTES) using a novel automated flexible stapling device显示文摘 | O. R. Meireles S. V. Kantsevoy L. R. Assumpcao P. Magno X. Dray S. A. Giday A. N. Kalloo E. J. Hanly M. R. Marohn | 2008 | Surgical Endoscopy2008，，7： | 2 |
| 10 | Heat release,time required, and cleaning ability of MTwo R and ProTaper universal re- treatment systems in the removal of filling material显示文摘 | Bramante C M Fidelis N S Assumpcao T S | 2010 | Journal of En- dodontics2010，36，11： | 1 |
| 11 | Interleukin-1 beta polymorphisms, Helicobacter pylori infection in individuals from Northern Brazil with gastric adenocarcinoma显示文摘 | GATTI L L BURBANO R R De ASSUMPCAO P P | 2004 | Clin Exp Med2004，4，2： | 1 |
| 12 | Novel DM- RTl SrUTR + IlinsT mutation associated to XY partial go- nadal dysgenesis显示文摘 | MelIo MP Coeli FB Assumpcao JG | 2010 | Arq Bras Endocrinol Metabol2010，54，： | 1 |
| 13 | A Model for Dynamic Analysis of AC Contactor显示文摘 | Paulo I Koltermann Assumpcao Bastos J P Sergio R Armda | 1992 | IEEE Transactions on Magnetics1992，28，2： | 1 |
| 14 | Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified? 显示文摘 | Gleisner AL Assumpcao L Cameron JL | 2007 | Cancer2007，110，11： | 1 |
| 15 | Functional MR imaging as a new paradigm for image guidance显示文摘 | Assumpcao L Choti M Pawlik TM | 2009 | Abdom Imaging2009，34，6： | 1 |
| 16 | Heat release, time required, and cleaning ability of MTwoR and ProTaper uni- versal retreatment systems in the removal of filling material 显示文摘 | Bramante CM Fidelis NS Assumpcao TS | 2010 | J Endod2010，36，11： | 1 |
| 17 | Autism and rign chromosome 13 显示文摘 | Assumpcao FB Kuczynski E | 2004 | Hongkong Jourmal of Psychiatry2004，4，1： | 1 |
| 18 | Treatment of the Painful Chronically Dislocated and Subluxated Hip in Cerebral Palsy With Hip Arthrodesis显示文摘 | De Moraes Barros Fucs PM Svartman C de Assumpcao RM | 2003 | Journal of Pediatric Orthopaedics2003，23，： | 1 |
| 19 | Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?显示文摘 | Gleisner AL Assumpcao L Cameron JL et a1 | 2007 | Cancer2007，110，11： | 1 |
| 20 | Interleukin-lbeta polymorphisms,Helicobacter pylori infection in individuals from Northern Brazil with gastric adenocarcinoma显示文摘 | Gatti LL Burbano RR de Assumpcao PP | 2004 | Clin Exp Med2004，4，： | 1 |
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