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| 1 | COVID-19: An overview and a clinical update显示文摘The outbreak of coronavirus disease-2019(COVID-19,previously known as 2019 nCoV)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in Wuhan City,China,has spread rapidly around the world.Most patients from the first cluster had an epidemiological connection to the Wuhan's Huanan Seafood Wholesale Market.Available evidence has shown that SARSCoV-2 can be easily transmitted from person to person through close contact and respiratory droplets,posing a substantial challenge to public health.At present,the research on SARS-CoV-2 is still in the primary stages.However,dexamethasone and remdesivir are appeared to be promising medical therapies.Still,there is no definite specific treatment,and the mainstay of treatment is still focused on supportive therapies.Currently,over 150 vaccines are under investigation.It is necessary to understand the nature of the virus and its clinical characteristics in order to find effectively manage the disease.The knowledge about this virus is rapidly evolving,and clinicians must update themselves regularly.The present review comprehensively summarizes the epidemiology,pathogenesis,clinical characteristics,and management of COVID-19 based on the current evidence. | Arunkumar Krishnan James P Hamilton Saleh A Alqahtani Tinsay A Woreta | 2021 | World Journal of Clinical Cases2021，9，1： | 5 |
| 2 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 3 | Lateral frontal lobe seizures 显示文摘 | Kotagal P Arunkumar G S | 1998 | Epilepsia1998，39，4： | 1 |
| 4 | Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells ( PC-3 ) 显示文摘 | VIJAYABABU M R ARUNKUMAR A KANAGA- RAJ P | 2006 | Mol Cell Biochem2006，287，12： | 1 |
| 5 | Astaxanthin restricts weight gain, promotes insulin sensitivity and curtails fatty liver disease in mice fed a obesity-promoting diet 显示文摘 | BHUVANESWARI S ARUNKUMAR E VISWANATHAN P | 2010 | Process Biochem2010，45，8： | 1 |
| 6 | Lateral frontal lobe seizures 显示文摘 | Kotagal P Arunkumar GS | 1998 | Epilepsia1998，39，4： | 1 |
| 7 | Microsatellite markers for the Indian golden silkmoth,Antheraea assama(Saturniidae:Lepidoptera)显示文摘 | ARUNKUMAR K P KIFAYATHULLAH L NAGARAJUJ J | 2009 | Mol Ecol Resour2009，9，1： | 1 |
| 8 | Structure-propertyre- lations in hexagonal and monoclinic BiPO4 : Eu3+ nanoparticles synthesized by polyol-rnediated method 显示文摘 | Arunkumar P Jayajothi C Jeyakumar D | 2012 | RSC Advances2012，4，2： | 1 |
| 9 | Parent and patient validated content for pediatric epilepsy quality of life assessment显示文摘 | G Arunkumar E Wyllie P Kotagal | 2004 | Epilepsia2004，41，： | 1 |
| 10 | Differential effect of chromium compounds on the immune response of the African mouth breeder Oreochromis mossambicus ( Peters ) 显示文摘 | Arunkumar R I Rajasekaran P Michael R D | 2000 | Fish & Shellfish Immunology2000，10，8： | 1 |
| 11 | Molecular phylogeny of silkmoths reveals the origin of domesticated silkmoth, Bombyx mori from Chinese Bombyx mandarina and paternal inheritance of Antheraea proylei mitoehondrial DNA 显示文摘 | Arunkumar K P Metta M Nagaraju J | 2006 | Mol Phylogenet Evol2006，40，： | 1 |
| 12 | Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells显示文摘 | VIJAYABABU M R ARUNKUMAR A KANAGARAJ P | 2006 | J Carcinog2006，5，： | 1 |
| 13 | Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3) 显示文摘 | Vijayababu M R Arunkumar A Kanag-araj P | 2006 | Mol Cell Biochem2006，287，12： | 1 |
| 14 | Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells(PC-3)显示文摘 | Senthilkumar K Elumalai P Arunkumar R | | 0，，： | 1 |
| 15 | Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells(PC-3)are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression显示文摘 | Vijayababu MR Kanagaraj P Arunkumar A | | 0，，11： | 1 |
| 16 | Molecular phylogeny of silkmoths reveals the origin of domesticated silkmoth, Bombyx mori from Chinese Bombyx mandarina and paternal inheritance of Antheraea proylei mitochondrial DNA 显示文摘 | ARUNKUMAR K P METTA M NAGARAJU J | 2006 | Molecular Phylogenetics and Evolution2006，40，2： | 1 |
| 17 | Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells(PC-3)显示文摘 | Vijayababu MR Arunkumar A Kanagaraj P | | 0，，： | 1 |
| 18 | Effects of quercetin on insulin-like growth factors (IG- Fs) and their binding protein 3 (IGFBP 3) secretion of apoptosis in human prostate cancer cells显示文摘 | Vijayababu M R Arunkumar A Kanagaraj P | | J Car cinog0，510，： | 1 |
| 19 | Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate-194-cancer cells (PC- 3) 显示文摘 | Vijayababu M R Arunkumar A Kanagaraj P | 2006 | Mol Cell Bioehem2006，287，2： | 1 |
| 20 | Quercetin downregulates matrix Metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3)显示文摘 | Vijayababu M R Arunkumar A Kanagaraj P | 2006 | Mol Cell Biochem2006，287，12： | 1 |
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