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| 1 | Antioxidant activity and phytochemical screening of the methanol extracts of Euphorbia hirta L显示文摘Objective:To assess antioxidant activities of different parts of Euphorbia hirta(E.hirta),and to search for new sources of safe and inexpensive antioxidants.Methods:Samples of leaves,stems, flowers and roots from E.hirta were tested for total phenolic content,and flavonoids content and in vitro antioxidant activity by diphenyl-1-picrylhydrazyl(DPPH) assay and reducing power was measured using cyanoferrate method.Results:The leaves extract exhibited a maximum DPPH scavenging activity of(72.96±0.78)%followed by the flowers,roots and stems whose scavenging activities were(52.45±0.66)%,(48.59±0.97)%,and(44.42±0.94)%,respectively.The standard butylated hydroxytoluene(BHT) was(75.13±0.75)%.The IC50,for leaves,flowers,roots,stems and BHT were 0.803,0.972,0.989,1.358 and 0.794 mg/mL,respectively.The reducing power of the leaves extract was comparable with that of ascorbic acid and found to be dose dependent. Leaves extract had the highest total phenolic content[(206.17±1.95) mg GAE/g],followed by flowers,roots and stems extracts which were(117.08±3.10) mg GAE/g,(83.15±1.19) mg GAE/g,and (65.70±1.72) mg GAE/g,respectively.On the other hand,total flavonoids content also from leave had the highest value[(37.970±0.003) mg CEQ/g],followed by flowers,roots and stems extracts which were(35.200±0.002) mg CEQ/g,(24.350±0.006) mg CEQ/g,and(24.120±0.004) mg CEQ/ g,respectively.HPTLC bioautography analysis of phenolic and antioxidant substance revealed phenolic compounds.Phytochemical screening of E.hirta leaf extract revealed the presence of reducing sugars,terpenoids,alkaloids,steroids,tannins,flavanoids and phenolic compounds. Conclusions:These results suggeste that E.hirta have strong antioxidant potential.Further study is necessary for isolation and characterization of the active antioxidant agents,which can be used to treat various oxidative stress-related diseases. | Abu Arra Basma Zuraini Zakaria Lacimanan Yoga Latha Sreenivasan Sasidharan | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 7 |
| 2 | Use of Sargassum fusiforme Extract and its Bioactive Molecules to inhibit HIV Infection: Bridging Two Paradigms between Eastern and Western Medicine显示文摘AIDS is a global pandemic that has seen the development of novel and effective treatments to improve the quality of life of those infected and reduction in the spread of the disease. While great advancements have been made in HIV/AIDS therapeutics, there is still no cure or viable vaccine in development. The high rate of HIV-1 mutation contributing to virus immune escape, combined with increase in sexual transmission and the significant clinical therapeutics side effects of the currently available treatments highlights the need for novel therapeutics with broad anti-viral activity against both CXCR4(X4) and CCR5(R5)-tropic viruses. In our search for novel modalities against HIV infection, we investigated several aqueous extracts from Traditional Chinese Medicine(TCM) collection and identified Sargassum fusiforme(S. fusiforme) as a potent inhibitor of HIV infection. Following the Western approach of drug discovery and development, we isolated several bioactive molecules from S. fusiforme and determined their mechanism of action. TCM and Western approaches to disease treatment and drug development have been shown to be complementary to each other. The former provides a rich medicinal history for natural compounds that can have clinical impact on a variety of illnesses, while the latter enables the application of chemical informatics with rational drug design approach coupled to mechanistic underpinnings of such therapeutics. This multistep paradigm is demonstrated in the example of S. fusiforme as a treatment to prevent HIV infection, as described in this review. | Hui-jun Guo Yan-ze Liu Elena E.Paskaleva Manoj Arra Jeffrey S.Kennedy Alexander Shekhtman Mario Canki | 2014 | Chinese Herbal Medicines2014，6，4： | 3 |
| 3 | A transmission electron microscopy study of the diversity of Candida albicans cells induced by Euphorbia hirta L.leaf extract in vitro显示文摘Objective:To determine the major changes in the microstructure of Candida albicans(C. albicans) after treatment with Euphorbia hirta(E.hirta) L.leaf extract.Methods:Transmission electron microscopy was used to study the ultrastructural changes caused by E.hirta extract on C. albicans cells al various exposure time.Results:It was found that the main abnormalities were the alterations in morphology,lysis and complete collapse of the yeast cells after 36 h of exposure to the extract.Whereas the control cultures showed a typical morphology of Candida with a uniform central density,typically structured nucleus,and a cytoplasm with several elements of endomembrane system and enveloped by a regular,intact cell wall.Conclusions:The significant antifungal activity shown by this methanol extract of E.hirta L.suggests its potential against infections caused by C.albicans.The extract may be developed as an anticandidal agent. | Abu Arra Basma Zakaria Zuraini Sreenivasan Sasidharan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 3 |
| 4 | Type I interferon-mediated pathway interacts with peroxisome proliferator activated receptor-γ (PPAR-γ): At the cross-road of pancreatic cancer cell proliferation显示文摘 | Alessandra Dicitore Michele Caraglia Germano Gaudenzi Gloria Manfredi Bruno Amato Daniela Mari Luca Persani Claudio Arra Giovanni Vitale | 2014 | BBA - Reviews on Cancer2014，，1： | 3 |
| 5 | Tumor necrosis factor-alpha in macrophages of heart,liver,kidney and in the pituitary gland显示文摘 | ARRAS MA HOCHE R BOHLE | 1996 | Cell Tissue Res1996，285，： | 1 |
| 6 | Therapeutic-cell vaccine forchronic HIV-1 infection显示文摘 | Lu W Arraes LC Ferreira WT | 2004 | Nat Med2004，10，： | 1 |
| 7 | Carbon-Carbon Double Bond Versus Carbonyl Group Hydrogenation: Controlling the Intramolecular Selectivity with Polyaniline-Supported Platinum Catalysts显示文摘 | Steffan M Klasovsk F Arras J | 2008 | Adv Synth Catal2008，350，9： | 1 |
| 8 | IKK {gamma} protein is a target of BAG3 regulatory activity in human tumor growth显示文摘 | Ammirante M Rosati A Arra C | 2010 | Proc Natl Acad Sci USA2010，107，16： | 1 |
| 9 | Study of immersion silver and tin printed - circuit - board surface finishes in lead - free solder applications 显示文摘 | Arra M Shangguan D Xie D J | 2004 | Journal of electronic materials2004，33，： | 1 |
| 10 | Intracexebral hemorrhage triggers intedeukin-6 and interleukin-10 release in blood显示文摘 | Dziedzic T Arras S Klimkowicaz A | 2002 | Stroke2002，33，： | 1 |
| 11 | Angiogenesis but not collateral growth is associated with ischemia after femoral artery occlusion 显示文摘 | Arras M Scholz D | 1997 | Am J Physiol1997，273，： | 1 |
| 12 | Mode of action of an isolate of Candida famata in biological control of Penicillium digitatum in orange fruits显示文摘 | Arras G | | 0，，3： | 1 |
| 13 | Identification of a molecular target mediating the general anesthetic actions of pentobarbital 显示文摘 | Zeller A Arras M Jurd R | 2007 | Mol Pharmacol2007，71，3： | 1 |
| 14 | The promoting effect of a dicyanamide based ionic liquid in the selective hydrogenation of citral显示文摘 | ARRAS J STEFFAN M SHAYEGHI Y | 2008 | Chem Commun2008，34，： | 1 |
| 15 | Solder balling of lead-free solder pastes 显示文摘 | Minna Arra Dongkai Shangguan Ristolainen Eero | 2002 | J Electron Mater2002，31，11： | 1 |
| 16 | Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb 显示文摘 | Arras M Ito WD Scholz D | 1998 | J Clin Invest1998，101，1： | 1 |
| 17 | A profibrotic function of IL-12p40 in experimental puhnonary fibrosis 显示文摘 | HUAUX F ARRAS M TOMASI D | 2002 | J Immunol2002，169，5： | 1 |
| 18 | A global climatolo-gy of ionospheric irregularities derived from GPS radiooccultation显示文摘 | Arras C Wickert J Beyerle G | 2008 | Geophysical research letters2008，35，14809： | 1 |
| 19 | Lung fibrosis induced by silica particles in NMRI mice is associated with an uprogulation of the p40 subunit of interleukin-12 and Th2 manifestations显示文摘 | HUAUX F LARDOT C ARRAS M | 1999 | Am J Respir Cell Mol Biol1999，20，4： | 1 |
| 20 | Mode of action of an isolate of Candida famata in biological control of Penicillium digitatum in orange fruit显示文摘 | ARRAS G | | 0，，08： | 1 |
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