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| 1 | Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles显示文摘The application of nanomedicines is increasing rapidly with the promise of targeted and efficient drug delivery.Nanomedicines address the shortcomings of conventional therapy,as evidenced by several preclinical and clinical investigations indicating site-specific drug delivery,reduced side effects,and better treatment outcome.The development of suitable and biocompatible drug delivery vehicles is a prerequisite that has been successfully achieved by using simple and functionalized liposomes,nanoparticles,hydrogels,micelles,dendrimers,and mesoporous particles.A variety of drug delivery vehicles have been established for the targeted and controlled delivery of therapeutic agents in a wide range of chronic diseases,such as diabetes,cancer,atherosclerosis,myocardial ischemia,asthma,pulmonary tuberculosis,Parkinson’s disease,and Alzheimer’s disease.After successful outcomes in preclinical and clinical trials,many of these drugs have been marketed for human use,such as Abraxane®,Caelyx®,Mepact®,Myocet®,Emend®,and Rapamune®.Apart from drugs/compounds,novel therapeutic agents,such as peptides,nucleic acids(DNA and RNA),and genes have also shown potential to be used as nanomedicines for the treatment of several chronic ailments.However,a large number of extensive clinical trials are still needed to ensure the short-term and long-term effects of nanomedicines in humans.This review discusses the advantages of various drug delivery vehicles for better understanding of their utility in terms of current medical needs.Furthermore,the application of a wide range of nanomedicines is also described in the context of major chronic diseases. | Akhand Pratap Singh Arpan Biswas Aparna Shukla Pralay Maiti | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 2 | Development of a mass model in estimating weight-wise particle size distribution using digital image processing显示文摘Particle size distribution of coarse aggregates through mechanical sieving gives results in terms of cumulative mass percent. But digital image processing generated size distribution of particles, while being fast and accurate, is often expressed in terms of area function or number of particles. In this paper, a mass model is developed which converts the image obtained size distribution to mass-wise distribution, making it readily comparable to mechanical sieving data. The concept of weight/particle ratio is introduced for mass reconstruction from 2D images of particle aggregates. Using this mass model, the effects of several particle shape parameters(such as major axis, minor axis, and equivalent diameter) on sieve-size of the particles is studied. It is shown that the sieve-size of a particle strongly depend upon the shape parameters, 91% of its variation being explained by major axis, minor axis, bounding box length and equivalent diameter. Furthermore, minor axis gives an overall accurate estimate of particle sieve-size, error in mean size(D-50) being just 0.4%. However, sieve-size of smaller particles(<20 mm) strongly depends upon the length of the smaller arm of the bounding box enclosing them and sieve-sizes of larger particles(>20 mm) are highly correlated to their equivalent diameters. Multiple linear regression analysis has been used to generate overall mass-wise particle size distribution, considering the influences of all these shape parameters on particle sieve-size. Multiple linear regression generated overall mass-wise particle size distribution shows a strong correlation with sieve generated data. The adjusted R-square value of the regression analysis is found to be 99 percent(w.r.t cumulative frequency). The method proposed in this paper provides a time-efficient way of producing accurate(up to 99%) mass-wise PSD using digital image processing and it can be used effectively to replace the mechanical sieving. | Maiti Abhik Chakravarty Debashish Biswas Kousik Halder Arpan | 2017 | International Journal of Mining Science and Technology2017，27，3： | 3 |
| 3 | Do medical students studying in the United Kingdom have an adequate factual knowledge of basic life support?显示文摘BACKGROUND: Healthcare professionals have a duty to maintain basic life support(BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they receive.METHODS: A cross-sectional, closed-response questionnaire was distributed to the fi rst-and fourth-year students studying at institutions in the United Kingdom. The paper questionnaire sought to quantify respondent's previous BLS training, factual knowledge of the BLS algorithm using five multiple choice questions(MCQs), and valuate their desire for further BLS training. Students received 1 point for each correctly identifi ed answer to the 5 MCQ's.RESULTS: A total of 3,732 complete responses were received from 21 medical schools. Eighty percent(n=2,999) of students completed a BLS course as part of their undergraduate medical studies. There was a signifi cant difference(P<0.001) in the percentage of the fourth-year students selecting the correct answer in all the MCQ's compared to the fi rst-year students except in identifyingthe correct depth of compressions required during CPR(P=0.095). Overall 10.3%(95% CI 9.9% to 10.7%) of respondents correctly identified the answer to 5 MCQ's on BLS: 9% of the first-year students(n=194) and 12% of the fourth-year students(n=190). On an institutional level the proportion of students answering all MCQ's correctly ranged from 2% to 54% at different universities. Eighty-one percent of students(n=3,031) wished for more BLS training in their curriculum.CONCLUSION: Factual knowledge of BLS is poor among medical students in the UK. There is a disparity in standards of knowledge across institutions and respondents indicating that they would like more training. | Robert D.Willmore Damjan Veljanoski Feray Ozdes Bethan Stephens James Mooney Seamus G.Crumley Arpan Doshi Philippa Davies Shreya Badhrinarayanan Emily Day Kristian Tattam April Wilson Nathan Crang Lorna Green Craig A.Mounsey Howell Fu Joseph Williams Michelle S.D'souza Dhanya Sebastian Liam A.Mcgiveron Matthew G.Percy James Cohen Imogen J.John Alice Lethbridge Imogen Watkins Omar Amin Mubasher A.Qamar John Gerrard Hanrahan Emily Cramond-Wong | 2019 | World Journal of Emergency Medicine2019，10，2： | 2 |
| 4 | Experimental investigation on martensitic transformation and fracture morphologies of austenitic stainless steel显示文摘 | Arpan Das Soumitra Tarafder | 2009 | International Journal of Plasticity2009，，11： | 2 |
| 5 | Influence of Tacking Sequence on Residual Stress and Distortion of Single Sided Fillet Submerged Arc Welded Joint显示文摘沉没弧焊(锯) 为由于高材料免职率在大结构加入高厚度材料是有益的。不一致的加热并且冷却产生热压力,随后,剩余强调并且失真。纵、横向的剩余压力和尖失真通常在焊接的沉没的弧的大面板结构被测量切关节。因此,这个现在的工作的目的是确定剩余应力和失真在并且在由于 stiffeners 钉放联合的焊接附近的数量。剩余应力并且附加的合适的控制的水平定序的附加顺序影响被要求最小化压力。在现在的学习, elasto 塑料的材料行为被认为开发预言剩余压力和尖失真,变化附加的机械模型定序的 thermo。模仿的结果表明附加顺序重重地影响剩余压力和单身者的变丑模式站在一起切关节。有限元素基于数字模型被从出版文学比较试验性的数据校准。从今以后,尖失真从内部地发达的试验性的安装被测量。一个公平协议在之间预言并且试验性的结果显示发达数字模型的坚韧性。然而,从现在的学习的最重要的结论声明那个钉焊接位置应该被放在对面到 fillet 焊接方面到最小化剩余应力。 | Arpan Kumar Mondal Pankaj Biswas Swarup Bag | 2015 | Journal of Marine Science and Application2015，14，3： | 2 |
| 6 | Influence of peach(Prunus persica Batsch)phenological stage on the short-term changes in oxidizable and labile pools of soil organic carbon and activities of carbon-cycle enzymes in the North-Western Himalayas显示文摘The labile organic carbon(C)and C-related enzymes are sensitive indicators capturing alterations of soil organic matter(SOM),even in a short-time scale.Although the effects of crop husbandry and land use change on these attributes have been well studied,there is no consensus about how plant phenology may impact them.This study aimed to determine the short-term effect o f six distinct phenological stages(PS-1:full bloom;PS-2:fruit set;PS-3:pit hardening;PS-4:physiological maturity;PS-5:60 d after physiological maturity;and PS-6:fall)o f peach on the changes in soil organic carbon(SOC)fractions of different oxidizability,labile C pools,and C-cycle enzyme activities in soils,for two consecutive years(2015 and 2016)in the North-Western Himalayas(NWH).Peach rhizosphere soils were sampled at the topsoil(0-15 cm)and subsoil(16-30 cm)layers,along with rhizosphere soils from adjacent perennial grasses,which served as a control.Values for most of the assessed parameters,including very labile C,labile C,microbial biomass C,permanganate oxidizable C,dissolved organic C,mineralizable C,amylase activity,and carboxymethyl-cellulase activity,were significantly(P<0.05)higher at PS-3 than at other phenological stages of peach.Conversely,a sudden decline in these soil variables was recorded at PS-5,followed by a slight buildup at PS-6,particularly in the topsoil of the peach orchard.Short-term changes in organic C fractions of different oxidizability,influenced by peach phenological stage,significantly(P<0.05)affected C management index,C pool index,and lability index.Both the C management index and lability index showed their highest values at PS-3 and their lowest values at PS-5,clearly indicating short-term accretion and depletion of SOC,in tandem with the peach phenological events.Principal component analysis suggested that a composite of soil indicators,including microbial biomass C,dissolved organic C,amylase,and invertase,could help detect short-term changes in SOC content.It is concluded that peach phenological events had a major impact on the short-term variations of the studied soil variables,which could be attributed to changes in the above-and belowground plant residues,as well as the extent of nutrients and water acquisition. | Sovan DEBNATH Brij Lai ATTRI Anil KUMAR Arun KISHOR Raj NARAYAN Kanchan SINHA Arpan BHOWMIK Anil SHARMA Desh Beer SINGH | 2020 | Pedosphere2020，30，5： | 2 |
| 7 | Zn-doped nickel iron(oxy)hydroxide nanocubes passivated by polyanions with high catalytic activity and corrosion resistance for seawater oxidation显示文摘Electrochemical water splitting to produce hydrogen fuel is a promising renewable energy-conversion technique.Large-scale electrolysis of freshwater may deplete water resources and cause water scarcity worldwide.Thus,seawater electrolysis is a potential solution to the future energy and water crisis.In seawater electrolysis,it is critical to develop cost-effective electrocatalysts to split seawater without chloride corrosion.Herein,we present zinc-doped nickel iron(oxy)hydroxide nanocubes passivated by negatively charged polyanions(NFZ-PBA-S)that exhibits outstanding catalytic activity,stability,and selectivity for seawater oxidation.Zn dopants and polyanion-rich passivated surface layers in NFZ-PBA-S could effectively repel chlorine ions and enhance corrosion resistance,enabling its excellent catalytic activity and stability for seawater oxidation. | So Jung Kim Heechae Choi Jeong Ho Ryu Kang Min Kim Sungwook Mhin Arpan Kumar Nayak Junghwan Bang Minyeong Je Ghulam Ali Kyung Yoon Chung Kyeong-Han Na Won-Youl Choi Sunghwan Yeo Jin Uk Jang HyukSu Han | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 8 | Morphologies and characteristics of deformation induced martensite during tensile deformation of 304LN stainless steel显示文摘 | Das Arpan Sivaprasad S Ghosh M | 2008 | Materials Science and Engineering A2008，486，： | 1 |
| 9 | Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation显示文摘 | ROY CN MAK HH ARPAN I | 2007 | Blood2007，109，9： | 1 |
| 10 | Development of an automated examination seating arrangement generation system using music inspired harmony search algorithm显示文摘 | ACHARYYA Arnav Losalka Arpan GUPTA Pravir Singh | 2011 | Advances in Intelligent and Soft Computing2011，130，1： | 1 |
| 11 | Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS 显示文摘 | Arpan I Willcocks R J Forbes SC | 2014 | Neurology2014，83，11： | 1 |
| 12 | Current differential di- agnoses and treatment options of vascular occlusions presenting as bilateral thalamic infarcts: a review of the literature显示文摘 | Nitin AG Arpan TL David R H | 2012 | JNIS2012，10，： | 1 |
| 13 | News coverage of social protests and the effects of photographs and prior attitudes显示文摘 | Arpan L M Baker K Lee Y | 2006 | Mass Communication Society2006，9，1： | 1 |
| 14 | An efficient copper (i) -catalyzed synthesis of diaryl selenides through C ( aryl) -Se bond formation using solvent acetonitrile as ligand 显示文摘 | Arpan D Korupalli C Sekar G | 2011 | Synth2011，14，： | 1 |
| 15 | Effect of Lead on Oxidative Stress, Na+K+ATPase Activity and Mitochondrial Electron Transport Chain Activity of the Brain of Clarias batrachus L.显示文摘 | Arpan Kumar Maiti Nimai Chandra Saha Goutam Paul | | 0，2010，： | 1 |
| 16 | Osteoblast response to phospholipid modified titanium surface显示文摘 | Arpan Satsangi Neera Satsangi Renee’ Glover Rajiv K Satsangi Joo L Ong | 2003 | Biomaterials2003，，25： | 1 |
| 17 | The Effects of Exemplification on Perceptions of News Credibility显示文摘 | Laura M. Arpan | 2009 | Mass Communication and Society2009，，3： | 1 |
| 18 | Morphologies and characteristics of deformation induced martensite during tensile deformation of 304LN stainless steel显示文摘 | Arpan Das | 2008 | MaterialScience Engineering A2008，486，12： | 1 |
| 19 | Morpholo- gies and characteristics of deformation induced mar- tensite during tensile deformation of 304LN stainless steel 显示文摘 | Arpan Das Sivaprasad S Ghosh M | 2008 | Materials Science and Engineering A2008，486，1： | 1 |
| 20 | Development of an automated examination seating arrangement generation system using music inspired harmony search algorithm显示文摘 | ACHARYYA Arnav LOSALKA Arpan GUPTA Pravir Singh | 2012 | Advances in Intelligent and Soft Computing2012，130，1： | 1 |
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